ID Y2559_MYCTU Reviewed; 452 AA.
AC P9WQN1; L0T9Z6; Q50739;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Uncharacterized AAA domain-containing protein Rv2559c;
GN OrderedLocusNames=Rv2559c; ORFNames=MTCY9C4.09;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011445;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SIMILARITY: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1
CC subfamily. {ECO:0000305}.
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DR EMBL; AL123456; CCP45355.1; -; Genomic_DNA.
DR PIR; C70728; C70728.
DR RefSeq; NP_217075.1; NC_000962.3.
DR RefSeq; WP_003899376.1; NZ_NVQJ01000032.1.
DR AlphaFoldDB; P9WQN1; -.
DR SMR; P9WQN1; -.
DR STRING; 83332.Rv2559c; -.
DR PaxDb; 83332-Rv2559c; -.
DR DNASU; 887368; -.
DR GeneID; 887368; -.
DR KEGG; mtu:Rv2559c; -.
DR TubercuList; Rv2559c; -.
DR eggNOG; COG2256; Bacteria.
DR InParanoid; P9WQN1; -.
DR OrthoDB; 9778364at2; -.
DR PhylomeDB; P9WQN1; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008047; F:enzyme activator activity; IBA:GO_Central.
DR GO; GO:0017116; F:single-stranded DNA helicase activity; IBA:GO_Central.
DR GO; GO:0000731; P:DNA synthesis involved in DNA repair; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18139; HLD_clamp_RarA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 1.10.3710.10; DNA polymerase III clamp loader subunits, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR032423; AAA_assoc_2.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR021886; MgsA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13779:SF7; ATPASE WRNIP1; 1.
DR PANTHER; PTHR13779; WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF16193; AAA_assoc_2; 1.
DR Pfam; PF12002; MgsA_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..452
FT /note="Uncharacterized AAA domain-containing protein
FT Rv2559c"
FT /id="PRO_0000104039"
FT BINDING 72..79
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 452 AA; 47499 MW; 2193C58CF20713E2 CRC64;
MPEAVSDGLF DVPGVPMTSG HDLGASAGAP LAVRMRPASL DEVVGQDHLL APGSPLRRLV
EGSGVASVIL YGPPGSGKTT LAALISQATG RRFEALSALS AGVKEVRAVI ENSRKALLHG
EQTVLFIDEV HRFSKTQQDA LLSAVEHRVV LLVAATTENP SFSVVAPLLS RSLILQLRPL
TAEDTRAVVQ RAIDDPRGLG RAVAVAPEAV DLLVQLAAGD ARRALTALEV AAEAAQAAGE
LVSVQTIERS VDKAAVRYDR DGDQHYDVVS AFIKSVRGSD VDAALHYLAR MLVAGEDPRF
IARRLMILAS EDIGMAGPSA LQVAVAAAQT VALIGMPEAQ LTLAHATIHL ATAPKSNAVT
TALAAAMNDI KAGKAGLVPA HLRDGHYSGA AALGNAQGYK YSHDDPDGVV AQQYPPDELV
DVDYYRPTGR GGEREIAGRL DRLRAIIRKK RG
//
