ID Y2613_METAC Reviewed; 424 AA.
AC Q8TMP0; Q8TMP1;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 2.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Uncharacterized serpin-like protein MA_2613/MA_2612;
GN OrderedLocusNames=MA_2613/MA_2612;
OS Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS C2A).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=188937;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX PubMed=11932238; DOI=10.1101/gr.223902;
RA Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT physiological diversity.";
RL Genome Res. 12:532-542(2002).
CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM05993.1; Type=Frameshift; Note=Produces two ORFs.; Evidence={ECO:0000305};
CC Sequence=AAM05994.1; Type=Frameshift; Note=Produces two ORFs.; Evidence={ECO:0000305};
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DR EMBL; AE010299; AAM05994.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AE010299; AAM05993.1; ALT_FRAME; Genomic_DNA.
DR AlphaFoldDB; Q8TMP0; -.
DR SMR; Q8TMP0; -.
DR STRING; 188937.MA_2613; -.
DR EnsemblBacteria; AAM05993; AAM05993; MA_2612.
DR EnsemblBacteria; AAM05994; AAM05994; MA_2613.
DR KEGG; mac:MA_2612; -.
DR KEGG; mac:MA_2613; -.
DR HOGENOM; CLU_2597669_0_0_2; -.
DR InParanoid; Q8TMP0; -.
DR PhylomeDB; Q8TMP0; -.
DR Proteomes; UP000002487; Chromosome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd19591; serpin_like; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF211; ACCESSORY GLAND PROTEIN ACP76A-RELATED; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
PE 3: Inferred from homology;
KW Protease inhibitor; Reference proteome; Serine protease inhibitor.
FT CHAIN 1..424
FT /note="Uncharacterized serpin-like protein MA_2613/MA_2612"
FT /id="PRO_0000094161"
FT SITE 372..373
FT /note="Reactive bond"
FT /evidence="ECO:0000255"
SQ SEQUENCE 424 AA; 48734 MW; 6E63AA3521092CA5 CRC64;
MKTLLIFTLT LLCSGCLEDT AVTPINTINP DSVEYYGVAA ANNAFAFDMY SKLVQLESRE
KNNILFSPYS VSAAMAICYE GTEGTAKEQI SNVFYFPANN TVFKVRLKET NDKVYSGSDG
YELENANAIW VQEEYPVKEE YIFNVKNYYR SEVTNLDFVE KPDESRDAIN EWVEDKTDRK
IKDIVPKGSI TDDTRLILTN AIYFNGKWEH EFDKKMTSKK TFYPTKREEV SVDMMYISSN
FNYSENLKAK IIELPYKGND LSMYIVLPKG NNITEFENNF TVNEYTELKY NMESLGDVET
SIPKFKFETK TELSDSLIEM GVADAFDLKL ANFSGISEIR LLISRMIHQD FIDVQEEVTE
AAASTTVFIG SVSSSKSKSR EFKADLPFIF FIEDRRTDCI LFMGKVEYPE YEGTGRFWSL
PWNK
//
