ID Y2839_DICDI Reviewed; 390 AA.
AC Q558W0; Q6XUX4;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=HIT domain-containing protein DDB_G0272839;
GN ORFNames=DDB_G0272839;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Chen Y., Huang C.-H.;
RT "Identification of a putative gene in slime mold with homology to the human
RT FHA-HIT gene.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: In contrast to other HIT domain proteins, lacks the conserved
CC histidine triad motif (HXHXH), suggesting it has no hydrolase activity.
CC {ECO:0000305}.
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DR EMBL; AY208849; AAP86339.1; -; mRNA.
DR EMBL; AAFI02000008; EAL71057.1; -; Genomic_DNA.
DR RefSeq; XP_644956.1; XM_639864.1.
DR AlphaFoldDB; Q558W0; -.
DR SMR; Q558W0; -.
DR STRING; 44689.Q558W0; -.
DR PaxDb; 44689-DDB0201560; -.
DR EnsemblProtists; EAL71057; EAL71057; DDB_G0272839.
DR GeneID; 8618634; -.
DR KEGG; ddi:DDB_G0272839; -.
DR dictyBase; DDB_G0272839; -.
DR eggNOG; KOG0562; Eukaryota.
DR HOGENOM; CLU_708682_0_0_1; -.
DR InParanoid; Q558W0; -.
DR OMA; IHINDNT; -.
DR PRO; PR:Q558W0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0033699; F:DNA 5'-adenosine monophosphate hydrolase activity; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:1990165; F:single-strand break-containing DNA binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0000012; P:single strand break repair; IBA:GO_Central.
DR CDD; cd01278; aprataxin_related; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR12486:SF4; APRATAXIN; 1.
DR PANTHER; PTHR12486; APRATAXIN-RELATED; 1.
DR Pfam; PF11969; DcpS_C; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..390
FT /note="HIT domain-containing protein DDB_G0272839"
FT /id="PRO_0000393722"
FT DOMAIN 232..343
FT /note="HIT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00464"
FT REGION 168..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 348
FT /note="H -> P (in Ref. 1; AAP86339)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 390 AA; 45107 MW; 2DBCEC98740FE139 CRC64;
MNFKRLITTS FTNQIKNMKF KKTISFKPFD INNRIIYDKE PTIVFKDQKS CLLKDTISTT
LEDGSKELKI KIGRFTPGLD SNNNYISSDI FEININNYSN KIDLCLNGKN PTFLRRKGKI
PTKVKNWEQL LGEQLEIRKS VTLEDGDIIS FLGLNGTTSS IQFTIEEDNE NEKEKEKEME
LDNDNTNTES IPPITSKSTS TSTSLIDTNK IQLKKHFEDP NSKNVGLSAL VYFCNKPESF
LDVVLYYDDK TVAVLDKYPK AKHHYLVIPR VEINTLDELT PSFIPMLEHM YNVADAIINE
IISKDNDDDN LKKSDFKLGF HAIPSMKRLH LHIISNDYNT KYLKNNKHWN SFTTEFYIPF
DKILNELKSN GKVKVSIKKK IKKNKKKLIH
//
