ID YAJC_MYCTU Reviewed; 115 AA.
AC P9WL75; L0TBQ2; P65025; Q50633;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Sec translocon accessory complex subunit YajC;
GN Name=yajC; OrderedLocusNames=Rv2588c; ORFNames=MTCY227.13;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011445;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein
CC secretase/insertase is a supercomplex required for protein secretion,
CC insertion of proteins into membranes, and assembly of membrane protein
CC complexes. While the SecYEG complex is essential for assembly of a
CC number of proteins and complexes, the SecDF-YajC-YidC subcomplex
CC facilitates these functions. {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBUNIT: Part of the SecDF-YidC-YajC translocase complex. The SecDF-
CC YidC-YajC translocase forms a supercomplex with SecYEG, called the
CC holo-translocon (HTL). {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the YajC family. {ECO:0000305}.
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DR EMBL; AL123456; CCP45384.1; -; Genomic_DNA.
DR PIR; C70726; C70726.
DR RefSeq; NP_217104.1; NC_000962.3.
DR RefSeq; WP_003413391.1; NZ_NVQJ01000023.1.
DR AlphaFoldDB; P9WL75; -.
DR SMR; P9WL75; -.
DR STRING; 83332.Rv2588c; -.
DR PaxDb; 83332-Rv2588c; -.
DR DNASU; 887346; -.
DR GeneID; 45426590; -.
DR GeneID; 887346; -.
DR KEGG; mtu:Rv2588c; -.
DR TubercuList; Rv2588c; -.
DR eggNOG; COG1862; Bacteria.
DR InParanoid; P9WL75; -.
DR OrthoDB; 2200301at2; -.
DR PhylomeDB; P9WL75; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003849; Preprotein_translocase_YajC.
DR NCBIfam; TIGR00739; yajC; 1.
DR PANTHER; PTHR33909; SEC TRANSLOCON ACCESSORY COMPLEX SUBUNIT YAJC; 1.
DR PANTHER; PTHR33909:SF1; SEC TRANSLOCON ACCESSORY COMPLEX SUBUNIT YAJC; 1.
DR Pfam; PF02699; YajC; 1.
DR SMART; SM01323; YajC; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Protein transport; Reference proteome;
KW Translocation; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..115
FT /note="Sec translocon accessory complex subunit YajC"
FT /id="PRO_0000014139"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 96..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 115 AA; 12967 MW; 5DACBA453C1F7C12 CRC64;
MESFVLFLPF LLIMGGFMYF ASRRQRRAMQ ATIDLHDSLQ PGERVHTTSG LEATIVAIAD
DTIDLEIAPG VVTTWMKLAI RDRILPDDDI DEELNEDLDK DVDDVAGERR VTNDS
//
