ID YEA4_KLULA Reviewed; 328 AA.
AC Q00974;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE RecName: Full=UDP-N-acetylglucosamine transporter YEA4;
DE AltName: Full=Golgi UDP-GlcNAc transporter;
GN Name=YEA4; Synonyms=MNN2; OrderedLocusNames=KLLA0B03157g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=ATCC 201343 / MG1/2;
RX PubMed=8650202; DOI=10.1073/pnas.93.12.5963;
RA Abeijon C., Robbins P.W., Hirschberg C.B.;
RT "Molecular cloning of the Golgi apparatus uridine diphosphate-N-
RT acetylglucosamine transporter from Kluyveromyces lactis.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:5963-5968(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Sugar transporter that specifically mediates the transport of
CC UDP-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into Golgi
CC vesicles where glycosyltransferases function.
CC {ECO:0000269|PubMed:8650202}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; AF106080; AAC49313.1; -; Genomic_DNA.
DR EMBL; CR382122; CAH02066.1; -; Genomic_DNA.
DR RefSeq; XP_451673.1; XM_451673.1.
DR AlphaFoldDB; Q00974; -.
DR SMR; Q00974; -.
DR STRING; 284590.Q00974; -.
DR TCDB; 2.A.7.10.1; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; 284590-Q00974; -.
DR GeneID; 2897052; -.
DR KEGG; kla:KLLA0_B03157g; -.
DR eggNOG; KOG1583; Eukaryota.
DR HOGENOM; CLU_033007_1_1_1; -.
DR InParanoid; Q00974; -.
DR OMA; NPFTGWH; -.
DR Proteomes; UP000000598; Chromosome B.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR013657; SCL35B1-4/HUT1.
DR NCBIfam; TIGR00803; nst; 1.
DR PANTHER; PTHR10778; SOLUTE CARRIER FAMILY 35 MEMBER B; 1.
DR PANTHER; PTHR10778:SF4; UDP-XYLOSE AND UDP-N-ACETYLGLUCOSAMINE TRANSPORTER; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..328
FT /note="UDP-N-acetylglucosamine transporter YEA4"
FT /id="PRO_0000213360"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 328 AA; 36667 MW; 93A31FACA804D1EF CRC64;
MSFVLILSLV FGGCCSNVIS FEHMVQGSNI NLGNIVTFTQ FVSVTLIQLP NALDFSHFPF
RLRPRHIPLK IHMLAVFLFF TSSVANNSVF KFDISVPIHI IIRCSGTTLT MIIGWAVCNK
RYSKLQVQSA IIMTLGAIVA SLYRDKEFSM DSLKLNTDSV GMTQKSMFGI FVVLVATALM
SLLSLLNEWT YNKCGKHWKE TLFYSHFLAL PLFMLGYTRL RDEFRDLLIS SDSMDIPIVK
LPIATKLFML IANNVTQFIC IKGVNMLASN TDALTLSVVL LVRKFVSLLL SVYIYKNVLS
VTAYLGTITV FLGAGLYSYG SVKTALPR
//
