ID YHF0_YEAST Reviewed; 697 AA.
AC P38721; D3DKS0;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 27-MAR-2024, entry version 148.
DE RecName: Full=Uncharacterized protein YHL050C;
GN OrderedLocusNames=YHL050C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; U11583; AAB65038.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06637.1; -; Genomic_DNA.
DR PIR; S48964; S48964.
DR RefSeq; NP_011813.1; NM_001179130.1.
DR AlphaFoldDB; P38721; -.
DR BioGRID; 36375; 5.
DR DIP; DIP-7155N; -.
DR STRING; 4932.YHL050C; -.
DR PaxDb; 4932-YHL050C; -.
DR PeptideAtlas; P38721; -.
DR TopDownProteomics; P38721; -.
DR EnsemblFungi; YHL050C_mRNA; YHL050C; YHL050C.
DR GeneID; 856335; -.
DR KEGG; sce:YHL050C; -.
DR AGR; SGD:S000001042; -.
DR SGD; S000001042; YHL050C.
DR VEuPathDB; FungiDB:YHL050C; -.
DR eggNOG; ENOG502QWCT; Eukaryota.
DR GeneTree; ENSGT00940000153173; -.
DR HOGENOM; CLU_011178_2_0_1; -.
DR InParanoid; P38721; -.
DR OrthoDB; 2039852at2759; -.
DR BioCyc; YEAST:G3O-31066-MONOMER; -.
DR BioGRID-ORCS; 856335; 0 hits in 10 CRISPR screens.
DR PRO; PR:P38721; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38721; Protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; ISS:SGD.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR14074:SF16; ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I; 1.
DR PANTHER; PTHR14074; HELICASE WITH DEATH DOMAIN-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
PE 4: Predicted;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..697
FT /note="Uncharacterized protein YHL050C"
FT /id="PRO_0000202875"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 246..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 79026 MW; DA03E607AB177F27 CRC64;
MADTPSVAVQ APPGYGKTEL FHLPLIALAS KGDVEYVSFL FVPYTVLLAN CMIRLGRCGC
LNVAPVRNFI EEGCDGVTDL YVGIYDDLAS TNFTDRIAAW ENIVECTFRT NNVKLGYLIV
DELHNFETEV YRQSQFGGIT NLDFDAFEKA IFLSGTAPEA VADAALQRIG LTGLAKKSMD
INELKRSEDL SRGLSSYPTR MFNLIKEKSK VPLGTNATTT ASTNVRTSAT TTASINVRTS
ATTTASINVR TSATTTESTN SNTNATTTES TNSSTNATTT ASTNSSTNAT TTESTNASAK
EDANKDGNAE DNRFHPVTDI NKEPYKRKGS QMVLLERKKL KAQFPNTSEN MNVLQFLGFR
SDEIKHLFLY GIDIYFCPEG VFTQYGLCKG CQKMFELCVC WAGQKVSYRR MAWEALAVER
MLRNDEEYKE YLEDIEPYHG DPVGYLKFFS VKRREIYSQI QRNYAWYLAI TRRRETISVL
DSTRGKQGSQ VFRMSGRQIK ELYYKVWSNL RESKTEVLQY FLNWDEKKCQ EEWEAKDDTV
FVEALEKVGV FQRLRSMTSA GLQGPQYVKL QFSRHHRQLR SRYELSLGMH LRDQLALGVT
PSKVPHWTAF LSMLIGLFYN KTFRQKLEYL LEQISEVWLL PHWLDLANVE VLAADNTRVP
LYMLMVAVHK ELDSDDVPDG RFDIILLCRD SSREVGE
//
