ID YIPF1_MOUSE Reviewed; 306 AA.
AC Q91VU1; Q3TZU1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=Protein YIPF1;
DE AltName: Full=YIP1 family member 1;
GN Name=Yipf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with YIPF6; this interaction may stabilize YIPF1.
CC May also form a ternary complex with YIPF2 and YIPF6.
CC {ECO:0000250|UniProtKB:Q9Y548}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000250|UniProtKB:Q9Y548}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9Y548}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000250|UniProtKB:Q9Y548}. Late endosome membrane
CC {ECO:0000250|UniProtKB:Q9Y548}. Note=Mainly localizes within
CC medial-/trans-Golgi and trans-Golgi network (TGN), while less so within
CC cis-Golgi. {ECO:0000250|UniProtKB:Q9Y548}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR EMBL; AK081205; BAC38163.1; -; mRNA.
DR EMBL; AK157536; BAE34116.1; -; mRNA.
DR EMBL; BC009080; AAH09080.1; -; mRNA.
DR CCDS; CCDS18437.1; -.
DR RefSeq; NP_663525.1; NM_145550.3.
DR AlphaFoldDB; Q91VU1; -.
DR SMR; Q91VU1; -.
DR BioGRID; 230974; 1.
DR STRING; 10090.ENSMUSP00000075113; -.
DR GlyCosmos; Q91VU1; 1 site, No reported glycans.
DR GlyGen; Q91VU1; 1 site.
DR iPTMnet; Q91VU1; -.
DR PhosphoSitePlus; Q91VU1; -.
DR MaxQB; Q91VU1; -.
DR PaxDb; 10090-ENSMUSP00000075113; -.
DR ProteomicsDB; 299621; -.
DR Antibodypedia; 3081; 96 antibodies from 18 providers.
DR DNASU; 230584; -.
DR Ensembl; ENSMUST00000075693.12; ENSMUSP00000075113.6; ENSMUSG00000057375.14.
DR GeneID; 230584; -.
DR KEGG; mmu:230584; -.
DR UCSC; uc008tzs.2; mouse.
DR AGR; MGI:1915532; -.
DR CTD; 54432; -.
DR MGI; MGI:1915532; Yipf1.
DR VEuPathDB; HostDB:ENSMUSG00000057375; -.
DR eggNOG; KOG3114; Eukaryota.
DR GeneTree; ENSGT00390000010157; -.
DR HOGENOM; CLU_059606_1_0_1; -.
DR InParanoid; Q91VU1; -.
DR OMA; GCKTYFF; -.
DR OrthoDB; 8905at2759; -.
DR PhylomeDB; Q91VU1; -.
DR TreeFam; TF313536; -.
DR BioGRID-ORCS; 230584; 3 hits in 78 CRISPR screens.
DR ChiTaRS; Yipf1; mouse.
DR PRO; PR:Q91VU1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q91VU1; Protein.
DR Bgee; ENSMUSG00000057375; Expressed in choroid plexus of fourth ventricle and 261 other cell types or tissues.
DR ExpressionAtlas; Q91VU1; baseline and differential.
DR Genevisible; Q91VU1; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0005797; C:Golgi medial cisterna; ISS:UniProtKB.
DR GO; GO:0000138; C:Golgi trans cisterna; ISS:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0030133; C:transport vesicle; ISO:MGI.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR006977; Yip1_dom.
DR InterPro; IPR039765; Yip5/YIPF1/YIPF2.
DR PANTHER; PTHR12822:SF4; PROTEIN YIPF1; 1.
DR PANTHER; PTHR12822; UNCHARACTERIZED; 1.
DR Pfam; PF04893; Yip1; 1.
PE 2: Evidence at transcript level;
KW Endosome; Glycoprotein; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..306
FT /note="Protein YIPF1"
FT /id="PRO_0000240869"
FT TOPO_DOM 1..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9Y548"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..162
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..227
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..306
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q9Y548"
FT REGION 30..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 297
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 120
FT /note="L -> F (in Ref. 1; BAE34116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 306 AA; 34258 MW; 680A5C88F750BA3A CRC64;
MAAVDDLQFE EFGDGATLLA ANPDATTINI EDPSVSFGHQ PRPPGSVGRE EDEELLGNND
SDETELLAGQ KRSSPFWTFE YYQTFFDVDT YQVFDRIKGS LLPVPGKNFV RLYIRSNPDL
YGPFWICATL VFAIAISGNL SNFLIHLGEK TYHYVPEFQK VSIAATVIYA YAWLVPLALW
GFLLWRNSKV MSMVSYSFLE IVCVYGYSLF IYIPTAVLWI IPQRVVRWVL VMIALGVSGS
VLVMTFWPAV REDNRRVALA TIVTIVLLHV LLSVGCLAYF FDAPEMDHLP AAITTPNQTV
TAAKSS
//
