ID YMN1_YEAST Reviewed; 365 AA.
AC Q03102; D6W0F4; Q6Q5K5;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 27-MAR-2024, entry version 167.
DE RecName: Full=Uncharacterized membrane protein YML131W;
GN OrderedLocusNames=YML131W; ORFNames=YM4987.04;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
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DR EMBL; Z50178; CAA90552.1; -; Genomic_DNA.
DR EMBL; AY557992; AAS56318.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09768.1; -; Genomic_DNA.
DR PIR; S58197; S58197.
DR RefSeq; NP_013575.1; NM_001182494.1.
DR AlphaFoldDB; Q03102; -.
DR SMR; Q03102; -.
DR BioGRID; 35074; 41.
DR DIP; DIP-5615N; -.
DR IntAct; Q03102; 2.
DR MINT; Q03102; -.
DR STRING; 4932.YML131W; -.
DR iPTMnet; Q03102; -.
DR MaxQB; Q03102; -.
DR PaxDb; 4932-YML131W; -.
DR PeptideAtlas; Q03102; -.
DR TopDownProteomics; Q03102; -.
DR EnsemblFungi; YML131W_mRNA; YML131W; YML131W.
DR GeneID; 854908; -.
DR KEGG; sce:YML131W; -.
DR AGR; SGD:S000004600; -.
DR SGD; S000004600; YML131W.
DR VEuPathDB; FungiDB:YML131W; -.
DR eggNOG; KOG1196; Eukaryota.
DR HOGENOM; CLU_026673_29_1_1; -.
DR InParanoid; Q03102; -.
DR OMA; DKVMGMT; -.
DR OrthoDB; 179761at2759; -.
DR BioCyc; YEAST:G3O-32709-MONOMER; -.
DR BioGRID-ORCS; 854908; 2 hits in 10 CRISPR screens.
DR PRO; PR:Q03102; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q03102; Protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05288; PGDH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR041694; ADH_N_2.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR045010; MDR_fam.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43205:SF19; PKS_ER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR Pfam; PF16884; ADH_N_2; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW Membrane; NADP; Oxidoreductase; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..365
FT /note="Uncharacterized membrane protein YML131W"
FT /id="PRO_0000203238"
FT TOPO_DOM 1..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..169
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..365
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 239
FT /note="V -> A (in Ref. 3; AAS56318)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 39976 MW; 11A71E0DA834F308 CRC64;
MVLAKQWVLK NLPTPGEPFN FHFHDPACTF ELIEKELSSE QLKDGELLLE TTYLSNDPAQ
KFWISSMDKN YAKGVQPGEI IPARGIGKVL ASRNKAFSPG DYVSAVTGWT THAIISQENV
QGLRKLDKNK VGKLWWYLSV LGGTSLTAYF IFFTYAQLQE REEDYGKVYL ISGAAGAVGT
VCIQLALNVF KASKVIAIAG GPEKVAFVES FGDNVVGVDY KDPSFKQKLI EAAGGENTVD
YFIDNVGSNV LEAGVLLLKQ RAMLIACGAI SAYNDPSKFV FKGYSFILTK RLVVKGVLVT
DNIDDFPKAL DKLGSLVKHG KIDLLKSATL EDGTGDKFKN VPLIWKGLFS GVNKGKLITK
VNNEE
//
