ID YPT35_CANAL Reviewed; 167 AA.
AC Q5AG56; A0A1D8PNK1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=Endosomal/vacuolar adapter protein YPT35 {ECO:0000305};
DE AltName: Full=PX domain-containing protein YPT35 {ECO:0000305};
GN Name=YPT35; OrderedLocusNames=CAALFM_C502980CA;
GN ORFNames=CaO19.11798, CaO19.4323;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Recruits the lipid transfer protein VPS13 to endosomal and
CC vacuolar membranes. {ECO:0000250|UniProtKB:P38815}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P38815};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:P38815}. Vacuole
CC membrane {ECO:0000250|UniProtKB:P38815}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P38815}.
CC -!- DOMAIN: The PX domain binds phosphatidylinositol 3-phosphate
CC (PtdIns(3)P) which is necessary for peripheral membrane localization.
CC {ECO:0000250|UniProtKB:P38815}.
CC -!- SIMILARITY: Belongs to the YPT35 family. {ECO:0000305}.
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DR EMBL; CP017627; AOW29718.1; -; Genomic_DNA.
DR RefSeq; XP_720629.1; XM_715536.1.
DR AlphaFoldDB; Q5AG56; -.
DR SMR; Q5AG56; -.
DR STRING; 237561.Q5AG56; -.
DR EnsemblFungi; C5_02980C_A-T; C5_02980C_A-T-p1; C5_02980C_A.
DR GeneID; 3637816; -.
DR KEGG; cal:CAALFM_C502980CA; -.
DR CGD; CAL0000199935; orf19.11798.
DR VEuPathDB; FungiDB:C5_02980C_A; -.
DR eggNOG; ENOG502S5IQ; Eukaryota.
DR HOGENOM; CLU_070610_2_0_1; -.
DR InParanoid; Q5AG56; -.
DR OMA; QWFMTNV; -.
DR OrthoDB; 2041724at2759; -.
DR PRO; PR:Q5AG56; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; ISS:UniProtKB.
DR GO; GO:0072657; P:protein localization to membrane; ISS:UniProtKB.
DR CDD; cd07280; PX_YPT35; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037917; Ypt35_PX.
DR PANTHER; PTHR45949; SORTING NEXIN-4; 1.
DR PANTHER; PTHR45949:SF2; SORTING NEXIN-4; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Endosome; Membrane; Reference proteome; Vacuole.
FT CHAIN 1..167
FT /note="Endosomal/vacuolar adapter protein YPT35"
FT /id="PRO_0000333492"
FT DOMAIN 46..167
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
SQ SEQUENCE 167 AA; 19494 MW; C60A772263E34D0B CRC64;
MNSDTTPTHR NKSNSISQLN KVLPVPIELH NGESLEQHQQ NHLNHITNVI VGEYHLISGE
FGKSYMTWQI KITINDLDYS SIVLYKRYNE IYQLRQDLLK IFPPHDHTIT TNIVPSLPPK
DNLSLDRLMM SKNWLEERRK GLQWFLSNVL LNPVFQNCSV VKQFVLS
//
