ID Z4YKJ7_MOUSE Unreviewed; 569 AA.
AC Z4YKJ7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Amino acid transporter {ECO:0000256|RuleBase:RU361216};
GN Name=Slc1a7 {ECO:0000313|Ensembl:ENSMUSP00000158982.2,
GN ECO:0000313|MGI:MGI:2444087};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000158982.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000158982.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000158982.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000158982.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000158982.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000256|RuleBase:RU361216}.
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DR RefSeq; NP_666367.2; NM_146255.2.
DR AlphaFoldDB; Z4YKJ7; -.
DR SMR; Z4YKJ7; -.
DR ProteomicsDB; 331097; -.
DR Antibodypedia; 46889; 166 antibodies from 22 providers.
DR DNASU; 242607; -.
DR Ensembl; ENSMUST00000238795.2; ENSMUSP00000158982.2; ENSMUSG00000008932.11.
DR GeneID; 242607; -.
DR KEGG; mmu:242607; -.
DR UCSC; uc008uao.2; mouse.
DR AGR; MGI:2444087; -.
DR CTD; 6512; -.
DR MGI; MGI:2444087; Slc1a7.
DR VEuPathDB; HostDB:ENSMUSG00000008932; -.
DR GeneTree; ENSGT00940000156073; -.
DR HOGENOM; CLU_019375_3_2_1; -.
DR OMA; NETLVHM; -.
DR OrthoDB; 49426at2759; -.
DR PhylomeDB; Z4YKJ7; -.
DR BioGRID-ORCS; 242607; 2 hits in 80 CRISPR screens.
DR ChiTaRS; Slc1a7; mouse.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000008932; Expressed in retinal neural layer and 17 other cell types or tissues.
DR ExpressionAtlas; Z4YKJ7; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015172; F:acidic amino acid transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0015501; F:glutamate:sodium symporter activity; IEA:Ensembl.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProt.
DR GO; GO:0001504; P:neurotransmitter uptake; IEA:Ensembl.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR11958:SF22; EXCITATORY AMINO ACID TRANSPORTER 5; 1.
DR PANTHER; PTHR11958; SODIUM/DICARBOXYLATE SYMPORTER-RELATED; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361216};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU361216};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361216};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361216};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361216}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 105..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 269..290
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 302..328
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 340..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
SQ SEQUENCE 569 AA; 61240 MW; 5E2A6CAF2F19B0B7 CRC64;
MEWCQQAGLS MVLDAVLARG RTVCKHNGLL ILSVLSVIVG CLLGFFLRTQ RLSPQEISYF
QFPGELLMRM LKMLILPLVV SSLMSGLASL DAKTSSRLGI LTVAYYLWTT FLAVVVGIIM
VSIIHPGGAA QKETTEQSGK PVMSSADALL DLVRNMFPAN LVEATFKQYR TKTTPVIKSP
RGAAEEAPRR IVIYGVQEDN GSRVQNFALD LTPPPEIVYK SEPGTSDGMN VLGIVIFSAT
MGIMLGRMGD SGTPLVSFCQ CLNESVMKIV AVAGWYFPFG IVFLIAGKIL EMDDPKAVGK
KLGFYAVTVV CGLVVHGLLI LPLLYFLITK KNPIVFIRGV LQALLIALAT SSSSATLPIT
FKCLLENNHI DRRIARFVLP VGATINMDGT ALYEAVAAIF IAQVNNYELD FGQIITISIT
ATAASIGAAG IPQAGLVTMV IVLTSVGLPT DDINLIIAVD WALDRFRTMI NVLGDALAAG
IMAHICRKDF AQDMGTEKLL PCETKPVTLQ EIVAAQQNGC VKSVAEASEL TLGPTCPHHI
PVQVEQDEDP AAASLDHCTI EISELETNV
//
