ID ZBT41_HUMAN Reviewed; 909 AA.
AC Q5SVQ8; A2RUA8; Q6MZT8; Q6ZR25; Q7Z4T1; Q8IZ99;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 162.
DE RecName: Full=Zinc finger and BTB domain-containing protein 41;
GN Name=ZBTB41; Synonyms=FRBZ1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Placenta;
RA Goudou D., Bitoun M., Rieger F., Perin J.-P., Alliel P.M.;
RT "Structure, gene mapping, and expression of FRBZ1.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 743-909.
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5SVQ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SVQ8-2; Sequence=VSP_023092, VSP_023093;
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DR EMBL; AY163816; AAN71742.2; -; mRNA.
DR EMBL; AY336933; AAP97434.1; -; mRNA.
DR EMBL; AK128549; BAC87496.1; -; mRNA.
DR EMBL; AL356315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL627208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132818; AAI32819.1; -; mRNA.
DR EMBL; BC136600; AAI36601.1; -; mRNA.
DR EMBL; BX640886; CAE45940.1; -; mRNA.
DR CCDS; CCDS30960.1; -. [Q5SVQ8-1]
DR RefSeq; NP_919290.2; NM_194314.2. [Q5SVQ8-1]
DR RefSeq; XP_016856694.1; XM_017001205.1. [Q5SVQ8-2]
DR AlphaFoldDB; Q5SVQ8; -.
DR SMR; Q5SVQ8; -.
DR BioGRID; 131819; 16.
DR IntAct; Q5SVQ8; 1.
DR STRING; 9606.ENSP00000356375; -.
DR iPTMnet; Q5SVQ8; -.
DR PhosphoSitePlus; Q5SVQ8; -.
DR BioMuta; ZBTB41; -.
DR DMDM; 74756116; -.
DR EPD; Q5SVQ8; -.
DR jPOST; Q5SVQ8; -.
DR MassIVE; Q5SVQ8; -.
DR MaxQB; Q5SVQ8; -.
DR PaxDb; 9606-ENSP00000356375; -.
DR PeptideAtlas; Q5SVQ8; -.
DR ProteomicsDB; 63949; -. [Q5SVQ8-1]
DR ProteomicsDB; 63950; -. [Q5SVQ8-2]
DR ABCD; Q5SVQ8; 2 sequenced antibodies.
DR Antibodypedia; 50783; 106 antibodies from 17 providers.
DR DNASU; 360023; -.
DR Ensembl; ENST00000367405.5; ENSP00000356375.3; ENSG00000177888.8. [Q5SVQ8-1]
DR Ensembl; ENST00000467322.1; ENSP00000502173.1; ENSG00000177888.8. [Q5SVQ8-2]
DR GeneID; 360023; -.
DR KEGG; hsa:360023; -.
DR MANE-Select; ENST00000367405.5; ENSP00000356375.3; NM_194314.3; NP_919290.2.
DR UCSC; uc001gtx.2; human. [Q5SVQ8-1]
DR AGR; HGNC:24819; -.
DR CTD; 360023; -.
DR DisGeNET; 360023; -.
DR GeneCards; ZBTB41; -.
DR HGNC; HGNC:24819; ZBTB41.
DR HPA; ENSG00000177888; Low tissue specificity.
DR neXtProt; NX_Q5SVQ8; -.
DR OpenTargets; ENSG00000177888; -.
DR PharmGKB; PA142670545; -.
DR VEuPathDB; HostDB:ENSG00000177888; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00550000075080; -.
DR HOGENOM; CLU_014920_0_0_1; -.
DR InParanoid; Q5SVQ8; -.
DR OMA; MVEKASF; -.
DR OrthoDB; 5302057at2759; -.
DR PhylomeDB; Q5SVQ8; -.
DR TreeFam; TF350933; -.
DR PathwayCommons; Q5SVQ8; -.
DR SignaLink; Q5SVQ8; -.
DR BioGRID-ORCS; 360023; 38 hits in 1219 CRISPR screens.
DR ChiTaRS; ZBTB41; human.
DR GenomeRNAi; 360023; -.
DR Pharos; Q5SVQ8; Tdark.
DR PRO; PR:Q5SVQ8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SVQ8; Protein.
DR Bgee; ENSG00000177888; Expressed in endothelial cell and 182 other cell types or tissues.
DR Genevisible; Q5SVQ8; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd18226; BTB_POZ_ZBTB41; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24406:SF8; C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24406; TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..909
FT /note="Zinc finger and BTB domain-containing protein 41"
FT /id="PRO_0000277814"
FT DOMAIN 88..152
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 207..230
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 361..383
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 389..411
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 422..445
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 463..485
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 491..514
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 518..541
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 547..569
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 575..597
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 603..625
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 631..654
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 668..690
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 696..718
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 724..747
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 252..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..320
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 627
FT /note="G -> D (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_023092"
FT VAR_SEQ 628..909
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_023093"
FT VARIANT 327
FT /note="D -> Y (in dbSNP:rs10494751)"
FT /id="VAR_030601"
FT CONFLICT 182
FT /note="F -> L (in Ref. 2; BAC87496)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 909 AA; 105192 MW; BAB9F19F2F40772F CRC64;
MKKRRKVTSN LEKIHLGYHK DSSEGNVAVE CDQVTYTHSA GRPTPEALHC YQELPPSPDQ
RKLLSSLQYN KNLLKYLNDD RQKQPSFCDL LIIVEGKEFS AHKVVVAVGS SYFHACLSKN
PSTDVVTLDH VTHSVFQHLL EFLYTSEFFV YKYEIPLVLE AAKFLDIIDA VKLLNNENVA
PFHSELTEKS SPEETLNELT GRLSNNHQCK FCSRHFCYKK SLENHLAKTH RSLLLGKKHG
LKMLERSFSA RRSKRNRKCP VKFDDTSDDE QESGDGSDNL NQENFDKEKS DRNDSEDPGS
EYNAEEDELE EEMSDEYSDI EEQSEKDHND AEEEPEAGDS VGNVHEGLTP VVIQNSNKKI
LQCPKCDKTF DRIGKYESHT RVHTGEKPFE CDICHQRYST KSNLTVHRKK HSNETEFHKK
EHKCPYCNKL HASKKTLAKH VKRFHPENAQ EFISIKKTKS ESWKCDICKK SFTRRPHLEE
HMILHSQDKP FKCTYCEEHF KSRFARLKHQ EKFHLGPFPC DICGRQFNDT GNLKRHIECT
HGGKRKWTCF ICGKSVRERT TLKEHLRIHS GEKPHLCSIC GQSFRHGSSY RLHLRVHHDD
KRYECDECGK TFIRHDHLTK HKKIHSGEKA HQCEECGKCF GRRDHLTVHY KSVHLGEKVW
QKYKATFHQC DVCKKIFKGK SSLEMHFRTH SGEKPYKCQI CNQSFRIKKT LTKHLVIHSD
ARPFNCQHCN ATFKRKDKLK YHIDHVHEIK SPDDPLSTSE EKLVSLPVEY SSDDKIFQTE
TKQYMDQPKV YQSEAKTMLQ NVSAEVCVPV TLVPVQMPDT PSDLVRHTTT LPPSSHEILS
PQPQSTDYPR AADLAFLEKY TLTPQPANIV HPVRPEQMLD PREQSYLGTL LGLDSTTGVQ
NISTNEHHS
//
