ID ZC21B_BOVIN Reviewed; 219 AA.
AC Q32KN7;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Zinc finger C2HC domain-containing protein 1B;
GN Name=ZC2HC1B; Synonyms=FAM164B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU01371};
CC -!- SIMILARITY: Belongs to the ZC2HC1 family. {ECO:0000305}.
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DR EMBL; BC110003; AAI10004.1; -; mRNA.
DR RefSeq; NP_001070531.1; NM_001077063.2.
DR AlphaFoldDB; Q32KN7; -.
DR STRING; 9913.ENSBTAP00000010726; -.
DR PaxDb; 9913-ENSBTAP00000010726; -.
DR Ensembl; ENSBTAT00000010726.4; ENSBTAP00000010726.3; ENSBTAG00000008159.4.
DR GeneID; 768003; -.
DR KEGG; bta:768003; -.
DR CTD; 153918; -.
DR VEuPathDB; HostDB:ENSBTAG00000008159; -.
DR VGNC; VGNC:37094; ZC2HC1B.
DR eggNOG; KOG3940; Eukaryota.
DR GeneTree; ENSGT00940000161511; -.
DR HOGENOM; CLU_098467_1_0_1; -.
DR InParanoid; Q32KN7; -.
DR OMA; WRRQHED; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000008159; Expressed in semen and 88 other cell types or tissues.
DR ExpressionAtlas; Q32KN7; baseline.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR026319; ZC2HC1A/B-like.
DR PANTHER; PTHR13555; C2H2 ZINC FINGER CGI-62-RELATED; 1.
DR PANTHER; PTHR13555:SF67; ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1B; 1.
DR Pfam; PF13913; zf-C2HC_2; 2.
DR PROSITE; PS52027; ZF_C2HC_C3H; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..219
FT /note="Zinc finger C2HC domain-containing protein 1B"
FT /id="PRO_0000280251"
FT ZN_FING 14..43
FT /note="C2HC/C3H-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
FT ZN_FING 117..146
FT /note="C2HC/C3H-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
FT REGION 190..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 18
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
FT BINDING 21
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
FT BINDING 33
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
FT BINDING 37
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
FT BINDING 124
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
FT BINDING 136
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
FT BINDING 140
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01371"
SQ SEQUENCE 219 AA; 24263 MW; 6204CB014CCE16E4 CRC64;
MAGAQPFLAD GNQELFPCEV CGRRFAADVL ERHGPICRKL FNKKRKPFNS LKQRLRGTDI
PTVGKAPQSK PQPVRKSNWR QHHEDFINAI QSAKQCTLAI KEGRPLPPPP PPTVNPDYIQ
CPYCKRRFNE TAASRHINFC KDQESRRVFD PAQTAARLAS RAQGRAQMSP KKELTVTSAV
GALLQNRALE ASAAPTRPAV DPASGAKLRQ GFAKSSKKD
//
