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Database: UniProt
Entry: ZN503_HUMAN
LinkDB: ZN503_HUMAN
Original site: ZN503_HUMAN 
ID   ZN503_HUMAN             Reviewed;         646 AA.
AC   Q96F45; Q8NAC5; Q96E25; Q96IJ0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   11-DEC-2019, entry version 144.
DE   RecName: Full=Zinc finger protein 503;
GN   Name=ZNF503; Synonyms=NOLZ1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC   TISSUE=Skin, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-646 (ISOFORM 1).
RC   TISSUE=Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
CC   -!- FUNCTION: May function as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q96F45-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96F45-2; Sequence=VSP_026395;
CC       Name=3;
CC         IsoId=Q96F45-3; Sequence=VSP_026394;
CC   -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC03999.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
DR   EMBL; BC007494; AAH07494.1; -; mRNA.
DR   EMBL; BC011625; AAH11625.1; -; mRNA.
DR   EMBL; BC013011; AAH13011.1; -; mRNA.
DR   EMBL; BC021165; AAH21165.1; -; mRNA.
DR   EMBL; AK092897; BAC03999.1; ALT_INIT; mRNA.
DR   CCDS; CCDS7350.1; -. [Q96F45-1]
DR   RefSeq; NP_116161.2; NM_032772.5. [Q96F45-1]
DR   SMR; Q96F45; -.
DR   BioGrid; 124306; 16.
DR   IntAct; Q96F45; 17.
DR   MINT; Q96F45; -.
DR   STRING; 9606.ENSP00000361602; -.
DR   iPTMnet; Q96F45; -.
DR   PhosphoSitePlus; Q96F45; -.
DR   BioMuta; ZNF503; -.
DR   DMDM; 74762652; -.
DR   EPD; Q96F45; -.
DR   jPOST; Q96F45; -.
DR   MassIVE; Q96F45; -.
DR   MaxQB; Q96F45; -.
DR   PaxDb; Q96F45; -.
DR   PeptideAtlas; Q96F45; -.
DR   PRIDE; Q96F45; -.
DR   ProteomicsDB; 76493; -. [Q96F45-1]
DR   ProteomicsDB; 76494; -. [Q96F45-2]
DR   ProteomicsDB; 76495; -. [Q96F45-3]
DR   DNASU; 84858; -.
DR   Ensembl; ENST00000372524; ENSP00000361602; ENSG00000165655. [Q96F45-1]
DR   GeneID; 84858; -.
DR   KEGG; hsa:84858; -.
DR   UCSC; uc001jxg.4; human. [Q96F45-1]
DR   CTD; 84858; -.
DR   EuPathDB; HostDB:ENSG00000165655.15; -.
DR   GeneCards; ZNF503; -.
DR   HGNC; HGNC:23589; ZNF503.
DR   HPA; HPA026848; -.
DR   MIM; 613902; gene.
DR   neXtProt; NX_Q96F45; -.
DR   OpenTargets; ENSG00000165655; -.
DR   PharmGKB; PA134904334; -.
DR   eggNOG; ENOG410IH04; Eukaryota.
DR   eggNOG; ENOG4111EZY; LUCA.
DR   GeneTree; ENSGT00390000014618; -.
DR   HOGENOM; HOG000043108; -.
DR   InParanoid; Q96F45; -.
DR   OMA; QHFLPHG; -.
DR   OrthoDB; 1163882at2759; -.
DR   PhylomeDB; Q96F45; -.
DR   TreeFam; TF324968; -.
DR   ChiTaRS; ZNF503; human.
DR   GenomeRNAi; 84858; -.
DR   Pharos; Q96F45; Tbio.
DR   PRO; PR:Q96F45; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q96F45; protein.
DR   Bgee; ENSG00000165655; Expressed in 213 organ(s), highest expression level in uterus.
DR   Genevisible; Q96F45; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0070315; P:G1 to G0 transition involved in cell differentiation; IDA:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR   GO; GO:0010629; P:negative regulation of gene expression; IDA:UniProtKB.
DR   GO; GO:0061351; P:neural precursor cell proliferation; IEA:Ensembl.
DR   InterPro; IPR022129; Tscrpt_rep_NocA-like.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF12402; nlz1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Alternative splicing; Metal-binding; Methylation; Nucleus;
KW   Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..646
FT                   /note="Zinc finger protein 503"
FT                   /id="PRO_0000292204"
FT   ZN_FING         514..542
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   COMPBIAS        17..51
FT                   /note="Gly-rich"
FT   COMPBIAS        141..322
FT                   /note="Gly-rich"
FT   COMPBIAS        392..490
FT                   /note="Ala-rich"
FT   MOD_RES         102
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT   MOD_RES         209
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT   MOD_RES         231
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT   MOD_RES         237
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT   MOD_RES         636
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT   VAR_SEQ         130..492
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_026394"
FT   VAR_SEQ         233..269
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_026395"
FT   VARIANT         509
FT                   /note="N -> K (in dbSNP:rs35764982)"
FT                   /id="VAR_032951"
SQ   SEQUENCE   646 AA;  62555 MW;  F7F341E6C8170B85 CRC64;
     MSTAPSLSAL RSSKHSGGGG GGGGGGGADP AWTSALSGNS SGPGPGSSPA GSTKPFVHAV
     PPSDPLRQAN RLPIKVLKML TARTGHILHP EYLQPLPSTP VSPIELDAKK SPLALLAQTC
     SQIGKPDPSP SSKLSSVASN GGGAGGAGGG AAGDKDTKSG PLKLSDIGVE DKSSFKPYSK
     PGSDKKEPGG GGGGGGGGGG GGGGVSSEKS GFRVPSATCQ PFTPRTGSPS SSASACSPGG
     MLSSAGGAPE GKDDKKDTDV GGGGKGTGGA SAEGGPTGLA HGRISCGGGI NVDVNQHPDG
     GPGGKALGSD CGGSSGSSSG SGPSAPTSSS VLGSGLVAPV SPYKPGQTVF PLPPAGMTYP
     GSLAGAYAGY PPQFLPHGVA LDPTKPGSLV GAQLAAAAAG SLGCSKPAGS SPLAGASPPS
     VMTASLCRDP YCLSYHCASH LAGAAAASAS CAHDPAAAAA ALKSGYPLVY PTHPLHGVHS
     SLTAAAAAGA TPPSLAGHPL YPYGFMLPND PLPHICNWVS ANGPCDKRFA TSEELLSHLR
     THTAFPGTDK LLSGYPSSSS LASAAAAAMA CHMHIPTSGA PGSPGTLALR SPHHALGLSS
     RYHPYSKSPL PTPGAPVPVP AATGPYYSPY ALYGQRLTTA SALGYQ
//
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