ID ZN710_HUMAN Reviewed; 664 AA.
AC Q8N1W2; A0AVS3; Q6ZMK9; Q8NDU0;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 27-MAR-2024, entry version 162.
DE RecName: Full=Zinc finger protein 710;
GN Name=ZNF710;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 387-664.
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 460-664.
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-110; LYS-113 AND LYS-377, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8N1W2; P63167: DYNLL1; NbExp=4; IntAct=EBI-18096911, EBI-349105;
CC Q8N1W2; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-18096911, EBI-1389308;
CC Q8N1W2; P51687: SUOX; NbExp=3; IntAct=EBI-18096911, EBI-3921347;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK094712; BAC04404.1; -; mRNA.
DR EMBL; BC126476; AAI26477.1; -; mRNA.
DR EMBL; BC130541; AAI30542.1; -; mRNA.
DR EMBL; AK160373; BAD18716.1; -; mRNA.
DR EMBL; AL831826; CAD38540.1; -; mRNA.
DR CCDS; CCDS10358.1; -.
DR RefSeq; NP_940928.2; NM_198526.3.
DR AlphaFoldDB; Q8N1W2; -.
DR SMR; Q8N1W2; -.
DR BioGRID; 131913; 3.
DR IntAct; Q8N1W2; 3.
DR STRING; 9606.ENSP00000268154; -.
DR iPTMnet; Q8N1W2; -.
DR PhosphoSitePlus; Q8N1W2; -.
DR BioMuta; ZNF710; -.
DR DMDM; 94730692; -.
DR EPD; Q8N1W2; -.
DR jPOST; Q8N1W2; -.
DR MassIVE; Q8N1W2; -.
DR MaxQB; Q8N1W2; -.
DR PaxDb; 9606-ENSP00000268154; -.
DR PeptideAtlas; Q8N1W2; -.
DR ProteomicsDB; 71643; -.
DR Antibodypedia; 28692; 55 antibodies from 14 providers.
DR DNASU; 374655; -.
DR Ensembl; ENST00000268154.9; ENSP00000268154.3; ENSG00000140548.10.
DR GeneID; 374655; -.
DR KEGG; hsa:374655; -.
DR MANE-Select; ENST00000268154.9; ENSP00000268154.3; NM_198526.4; NP_940928.2.
DR UCSC; uc002bov.3; human.
DR AGR; HGNC:25352; -.
DR CTD; 374655; -.
DR DisGeNET; 374655; -.
DR GeneCards; ZNF710; -.
DR HGNC; HGNC:25352; ZNF710.
DR HPA; ENSG00000140548; Tissue enhanced (pancreas).
DR neXtProt; NX_Q8N1W2; -.
DR OpenTargets; ENSG00000140548; -.
DR PharmGKB; PA142670470; -.
DR VEuPathDB; HostDB:ENSG00000140548; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161170; -.
DR HOGENOM; CLU_002678_54_1_1; -.
DR InParanoid; Q8N1W2; -.
DR OMA; VEKRWQC; -.
DR OrthoDB; 2967614at2759; -.
DR PhylomeDB; Q8N1W2; -.
DR TreeFam; TF331510; -.
DR PathwayCommons; Q8N1W2; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N1W2; -.
DR BioGRID-ORCS; 374655; 13 hits in 1181 CRISPR screens.
DR ChiTaRS; ZNF710; human.
DR GenomeRNAi; 374655; -.
DR Pharos; Q8N1W2; Tdark.
DR PRO; PR:Q8N1W2; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8N1W2; Protein.
DR Bgee; ENSG00000140548; Expressed in cervix squamous epithelium and 201 other cell types or tissues.
DR ExpressionAtlas; Q8N1W2; baseline and differential.
DR Genevisible; Q8N1W2; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 10.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24384:SF189; DEFORMED WINGS-RELATED; 1.
DR PANTHER; PTHR24384; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..664
FT /note="Zinc finger protein 710"
FT /id="PRO_0000233708"
FT ZN_FING 295..317
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 323..345
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 351..373
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 379..401
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 407..429
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 435..457
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 463..485
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 491..513
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 519..541
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 547..569
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 575..598
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 121..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 110
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 113
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 377
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CONFLICT 601
FT /note="M -> I (in Ref. 1; BAC04404)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 664 AA; 74461 MW; D7EF1DB9CD6F8429 CRC64;
MEGFMDSGTQ TDAVVVLSLA QAAVLGLVSE NELFGATISA EAFYPDLGPE LSGAAMGEPE
PPGPDVYQLA CNGRALEEPA EEEVLEVEAA CEKHTRRKTR PPVRLVPKVK FEKVEEEEQE
VYEVSVPGDD KDAGPAEAPA EAASGGCDAL VQSSAVKMID LSAFSRKPRT LRHLPRTPRP
ELNVAPYDPH FPAPARDGFP EPSMALPGPE ALPTECGFEP PHLAPLSDPE APSMESPEPV
KPEQGFVWQE ASEFEADTAG STVERHKKAQ LDRLDINVQI DDSYLVEAGD RQKRWQCRMC
EKSYTSKYNL VTHILGHNGI KPHSCPHCSK LFKQPSHLQT HLLTHQGTRP HKCQVCHKAF
TQTSHLKRHM LLHSEVKPYS CHFCGRGFAY PSELKAHEVK HESGRCHVCV ECGLDFSTLT
QLKRHLASHQ GPTLYQCLEC DKSFHYRSQL QNHMLKHQNV RPFVCTECGM EFSQIHHLKQ
HSLTHKGVKE FKCEVCGREF TLQANMKRHM LIHTSVRPYQ CHICFKTFVQ KQTLKTHMIV
HSPVKPFKCK VCGKSFNRMY NLLGHMHLHA GSKPFKCPYC SSKFNLKGNL SRHMKVKHGV
MDIGLDSQDP MMELTGTDPS ELDGQQEMED FEENAYSYAS VDSSAEASVL TEQAMKEMAY
YNVL
//
