ID ZSWM3_HUMAN Reviewed; 696 AA.
AC Q96MP5; Q9BR13;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 24-JAN-2024, entry version 142.
DE RecName: Full=Zinc finger SWIM domain-containing protein 3;
GN Name=ZSWIM3; Synonyms=C20orf164;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-259.
RC TISSUE=Fetal brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96MP5; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-5235554, EBI-10961624;
CC Q96MP5; Q96IK5: GMCL1; NbExp=3; IntAct=EBI-5235554, EBI-2548508;
CC Q96MP5; Q12933: TRAF2; NbExp=3; IntAct=EBI-5235554, EBI-355744;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK056641; BAB71239.1; -; mRNA.
DR EMBL; AL008726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027611; AAH27611.1; -; mRNA.
DR CCDS; CCDS13381.1; -.
DR RefSeq; NP_542790.2; NM_080752.3.
DR AlphaFoldDB; Q96MP5; -.
DR SMR; Q96MP5; -.
DR BioGRID; 126724; 5.
DR IntAct; Q96MP5; 4.
DR STRING; 9606.ENSP00000255152; -.
DR GlyGen; Q96MP5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96MP5; -.
DR PhosphoSitePlus; Q96MP5; -.
DR BioMuta; ZSWIM3; -.
DR DMDM; 41019518; -.
DR EPD; Q96MP5; -.
DR MassIVE; Q96MP5; -.
DR MaxQB; Q96MP5; -.
DR PaxDb; 9606-ENSP00000255152; -.
DR PeptideAtlas; Q96MP5; -.
DR ProteomicsDB; 77384; -.
DR Antibodypedia; 43809; 67 antibodies from 14 providers.
DR DNASU; 140831; -.
DR Ensembl; ENST00000255152.3; ENSP00000255152.2; ENSG00000132801.7.
DR GeneID; 140831; -.
DR KEGG; hsa:140831; -.
DR MANE-Select; ENST00000255152.3; ENSP00000255152.2; NM_080752.4; NP_542790.2.
DR UCSC; uc002xqd.4; human.
DR AGR; HGNC:16157; -.
DR CTD; 140831; -.
DR DisGeNET; 140831; -.
DR GeneCards; ZSWIM3; -.
DR HGNC; HGNC:16157; ZSWIM3.
DR HPA; ENSG00000132801; Low tissue specificity.
DR MIM; 620336; gene.
DR neXtProt; NX_Q96MP5; -.
DR OpenTargets; ENSG00000132801; -.
DR PharmGKB; PA25706; -.
DR VEuPathDB; HostDB:ENSG00000132801; -.
DR eggNOG; ENOG502QVJ3; Eukaryota.
DR GeneTree; ENSGT00390000017273; -.
DR HOGENOM; CLU_398444_0_0_1; -.
DR InParanoid; Q96MP5; -.
DR OMA; LNTQHVH; -.
DR OrthoDB; 5296025at2759; -.
DR PhylomeDB; Q96MP5; -.
DR TreeFam; TF335703; -.
DR PathwayCommons; Q96MP5; -.
DR SignaLink; Q96MP5; -.
DR BioGRID-ORCS; 140831; 11 hits in 1155 CRISPR screens.
DR ChiTaRS; ZSWIM3; human.
DR GenomeRNAi; 140831; -.
DR Pharos; Q96MP5; Tdark.
DR PRO; PR:Q96MP5; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q96MP5; Protein.
DR Bgee; ENSG00000132801; Expressed in oocyte and 148 other cell types or tissues.
DR Genevisible; Q96MP5; HS.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR006564; Znf_PMZ.
DR InterPro; IPR007527; Znf_SWIM.
DR InterPro; IPR048326; ZSWIM1-3_helical.
DR InterPro; IPR048324; ZSWIM1-3_RNaseH-like.
DR InterPro; IPR045563; ZSWIM1/3_C.
DR InterPro; IPR048325; ZSWIM3_N.
DR PANTHER; PTHR31569; SWIM-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31569:SF3; ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF04434; SWIM; 1.
DR Pfam; PF19286; ZSWIM1-3_C; 1.
DR Pfam; PF21600; ZSWIM1-3_helical; 1.
DR Pfam; PF21056; ZSWIM1-3_RNaseH-like; 1.
DR Pfam; PF21599; ZSWIM3_N; 1.
DR SMART; SM00575; ZnF_PMZ; 1.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..696
FT /note="Zinc finger SWIM domain-containing protein 3"
FT /id="PRO_0000223099"
FT ZN_FING 531..572
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT VARIANT 259
FT /note="V -> A (in dbSNP:rs2903808)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_053769"
FT VARIANT 291
FT /note="R -> W (in dbSNP:rs35928298)"
FT /id="VAR_062161"
FT CONFLICT 329
FT /note="R -> S (in Ref. 1; BAB71239)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 696 AA; 79454 MW; 30C91C23ACB1AF23 CRC64;
MELGSCFKTY EDFKECFSAY KRENRCSFIL RDCVSVRFHN LNHGTSIRED ILYVQVKFVC
IRTQSNRKRT READMCPAYL LLRYNERLDR LFISELNTQH IHGDSKVASP GGDTTGKSQK
TMCLQRLQPV QPTTKKDLDT AEKSLVEPSF CLDKVQVSSK PEQEGITPSD LAKIAKVMKN
FLKVDEGSMA SFSVGDSQHL DRLSFQSSKM TDLFIRFPEN LLLHRVENTQ GHILYAFLVE
NKERESRVVH FAVLKAETVT SVAKMLSIFT EFNSDWPKVK VVFVDPSFHY RAILQEIFPA
ARILLSIYHT TRLLEKKLHR SSANPSFKRL MKEALREAVF VTSEASLKNL CQMSQAVLDE
DLFNFLQAHW FTCELLWYMH VRKGLLACNT YMDSLDIVTS KVSSLFREQQ SLLDCILCFV
DYIDFFNTKG LKNLPTPPPK LKRARPASMP LKSKKAFGIC GESLTSLPAE ETKPDAQQVQ
VQQQSQVPPS QVGMLDTLHQ SGSELAYKLC HNEWEVVQNS THLVDMAGSS VDVQLLEDSH
QVSKDGCSCS CSFQQWYHLP CRHILALLHT SQQPVGEAMV CRRWQKKYQY LLGPNGELQD
RGMVPNTGQP EKQGRNDMIQ DLSRELANLL MQTEGPELEE RYSTLRKIVD IWAGPSQPSE
LFQQPGDFKD VGRLPFLWGK QEEGEGFPPA TAVMHY
//
