KEGG   Vulpes vulpes (red fox): 112930054
Entry
112930054         CDS       T05911                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
vvp  Vulpes vulpes (red fox)
Pathway
vvp00562  Inositol phosphate metabolism
vvp01100  Metabolic pathways
vvp04015  Rap1 signaling pathway
vvp04020  Calcium signaling pathway
vvp04022  cGMP-PKG signaling pathway
vvp04062  Chemokine signaling pathway
vvp04070  Phosphatidylinositol signaling system
vvp04071  Sphingolipid signaling pathway
vvp04072  Phospholipase D signaling pathway
vvp04261  Adrenergic signaling in cardiomyocytes
vvp04270  Vascular smooth muscle contraction
vvp04310  Wnt signaling pathway
vvp04371  Apelin signaling pathway
vvp04540  Gap junction
vvp04611  Platelet activation
vvp04613  Neutrophil extracellular trap formation
vvp04621  NOD-like receptor signaling pathway
vvp04713  Circadian entrainment
vvp04720  Long-term potentiation
vvp04723  Retrograde endocannabinoid signaling
vvp04724  Glutamatergic synapse
vvp04725  Cholinergic synapse
vvp04726  Serotonergic synapse
vvp04728  Dopaminergic synapse
vvp04730  Long-term depression
vvp04742  Taste transduction
vvp04750  Inflammatory mediator regulation of TRP channels
vvp04911  Insulin secretion
vvp04912  GnRH signaling pathway
vvp04915  Estrogen signaling pathway
vvp04916  Melanogenesis
vvp04918  Thyroid hormone synthesis
vvp04919  Thyroid hormone signaling pathway
vvp04921  Oxytocin signaling pathway
vvp04922  Glucagon signaling pathway
vvp04924  Renin secretion
vvp04925  Aldosterone synthesis and secretion
vvp04926  Relaxin signaling pathway
vvp04927  Cortisol synthesis and secretion
vvp04928  Parathyroid hormone synthesis, secretion and action
vvp04929  GnRH secretion
vvp04933  AGE-RAGE signaling pathway in diabetic complications
vvp04934  Cushing syndrome
vvp04935  Growth hormone synthesis, secretion and action
vvp04961  Endocrine and other factor-regulated calcium reabsorption
vvp04970  Salivary secretion
vvp04971  Gastric acid secretion
vvp04972  Pancreatic secretion
vvp04973  Carbohydrate digestion and absorption
vvp05010  Alzheimer disease
vvp05016  Huntington disease
vvp05017  Spinocerebellar ataxia
vvp05022  Pathways of neurodegeneration - multiple diseases
vvp05142  Chagas disease
vvp05143  African trypanosomiasis
vvp05146  Amoebiasis
vvp05163  Human cytomegalovirus infection
vvp05200  Pathways in cancer
vvp05415  Diabetic cardiomyopathy
vvp05417  Lipid and atherosclerosis
Module
vvp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:vvp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112930054 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    112930054 (PLCB1)
   04310 Wnt signaling pathway
    112930054 (PLCB1)
   04371 Apelin signaling pathway
    112930054 (PLCB1)
   04020 Calcium signaling pathway
    112930054 (PLCB1)
   04070 Phosphatidylinositol signaling system
    112930054 (PLCB1)
   04072 Phospholipase D signaling pathway
    112930054 (PLCB1)
   04071 Sphingolipid signaling pathway
    112930054 (PLCB1)
   04022 cGMP-PKG signaling pathway
    112930054 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    112930054 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112930054 (PLCB1)
   04613 Neutrophil extracellular trap formation
    112930054 (PLCB1)
   04621 NOD-like receptor signaling pathway
    112930054 (PLCB1)
   04062 Chemokine signaling pathway
    112930054 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    112930054 (PLCB1)
   04922 Glucagon signaling pathway
    112930054 (PLCB1)
   04929 GnRH secretion
    112930054 (PLCB1)
   04912 GnRH signaling pathway
    112930054 (PLCB1)
   04915 Estrogen signaling pathway
    112930054 (PLCB1)
   04921 Oxytocin signaling pathway
    112930054 (PLCB1)
   04926 Relaxin signaling pathway
    112930054 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    112930054 (PLCB1)
   04918 Thyroid hormone synthesis
    112930054 (PLCB1)
   04919 Thyroid hormone signaling pathway
    112930054 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    112930054 (PLCB1)
   04916 Melanogenesis
    112930054 (PLCB1)
   04924 Renin secretion
    112930054 (PLCB1)
   04925 Aldosterone synthesis and secretion
    112930054 (PLCB1)
   04927 Cortisol synthesis and secretion
    112930054 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112930054 (PLCB1)
   04270 Vascular smooth muscle contraction
    112930054 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    112930054 (PLCB1)
   04971 Gastric acid secretion
    112930054 (PLCB1)
   04972 Pancreatic secretion
    112930054 (PLCB1)
   04973 Carbohydrate digestion and absorption
    112930054 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    112930054 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    112930054 (PLCB1)
   04725 Cholinergic synapse
    112930054 (PLCB1)
   04728 Dopaminergic synapse
    112930054 (PLCB1)
   04726 Serotonergic synapse
    112930054 (PLCB1)
   04720 Long-term potentiation
    112930054 (PLCB1)
   04730 Long-term depression
    112930054 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    112930054 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    112930054 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    112930054 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    112930054 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112930054 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    112930054 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112930054 (PLCB1)
   05142 Chagas disease
    112930054 (PLCB1)
   05143 African trypanosomiasis
    112930054 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112930054 (PLCB1)
   05016 Huntington disease
    112930054 (PLCB1)
   05017 Spinocerebellar ataxia
    112930054 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    112930054 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112930054 (PLCB1)
   05415 Diabetic cardiomyopathy
    112930054 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    112930054 (PLCB1)
   04934 Cushing syndrome
    112930054 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vvp04131]
    112930054 (PLCB1)
Enzymes [BR:vvp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     112930054 (PLCB1)
Membrane trafficking [BR:vvp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    112930054 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    112930054 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLC-beta_C EF-hand_like DUF1154
Other DBs
NCBI-GeneID: 112930054
NCBI-ProteinID: XP_025868076
UniProt: A0A3Q7TSA6
Position
Unknown
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQVSNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSETGTNPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQMDLEQEYQDKFKRLPLEILEFVQEAMKGKISEESNHSSAPPSLASDPGKLNHKPPSS
EELEGDNPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggcgcagcccggagtgcacgctttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgtgactcca
attattttgaggacggaccctcagggatttttcttttactggacagatcaaaataaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaaacatgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcggacgcctggagcat
cgcatgataacggtggtgtatgggcctgacttagttaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtcaagagatgcatttctggaaaaagcctatactaagcttaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgt
cctcgacctgaaattgataatatcttttccgaatttggtgccaaaagcaaaccatacctt
accgttgatcagatgatggattttatcaaccttaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagaacaagtccaagtattgattgagaagtatgaaccc
aacaatagcctcgccaaaaaaggacagatttcagtggatggctttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgta
gagttggactgctggaagggtcgaactgctgaagaggaaccagtcatcacccatgggttc
accatgacaaccgaaatatccttcaaggaagtaatagaagcaattgctgagtgtgcattt
aagacgtcaccttttccaattctgctttcatttgagaaccacgtagattccccaaagcag
caagccaagatggcggagtattgtcgactgatctttggagatgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcccacaagtcttcagaaggaagtggcaaaaag
aagctctcagaacaagtctccaacacgtacagtgactcctccagcatgtttgagccctca
tctccaggagctggggaagctgataccgagagtgatgatgatgatgatgatgatgactgt
aaaaaatcttctatggatgaggggactgccgggagtgaggccatggccacagaagagatg
tctaacctggtgaactatattcaaccagtcaagtttgagtcatttgaaatttcaaaaaaa
agaaatagaagttttgaaatgtcttctttcgtggaaaccaaaggactagagcaactgaca
aagtctccagtggaatttgtagaatataacaaaatgcagcttagtaggatatatccaaaa
ggaacccgtgtggattcatctaactacatgcctcagctcttctggaatgcaggttgtcaa
atggttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtat
gaatacaatgggaaaagtggctacagattaaagccagagttcatgaggagacctgacaag
cattttgatccattcaccgaaggcatcgtggatgggatagtggccaatactttatctgtc
aagattatttcaggtcagtttctttctgataagaaagttgggacttacgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaagga
aatgctgtaaatcctgtctgggaagaagagcccattgtgttcaaaaaggtggttcttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttatcggtcaccgg
atcttgccagtacaggcaattcggccaggctatcactacatctgtctgaggaatgagagg
aaccagcctctgatgcttccagctgtgtttgtctacatagaggtgaaagactatgtccca
gatacctatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatg
gaacagagagctaaacaactggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacaccgtcagaagctccaagtgaaactgggacaaatccagca
gaaaacggagtgaatcacactacatctctggcacccaaaccaccctcccaggccctccac
agccaaccagctccaggctctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtggaagcacagaccattgaagagctaaagcaacagaaatcgtttgtg
aaacttcaaaagaaacactacaaagaaatgaaagacctggttaaaagacaccacaagaaa
accacagaccttatcaaagaacacactacaaaatataatgaaattcagaatgactacttg
agaaggagggcagctttggaaaagacagccaaaaaggacagtaagaaaaaatcagatccc
agcagtcctgaccatggttcatcaacaattgagcaagatcttgctgcccttgatgccgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagagcagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaa
aaattgacggatgttgctgaagaatgtcagaacaatcagttgaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaaaaggcaggagaagata
acagaagctaaatcgaaagacaaaagtcaaatggaagaggaaaagacagagatgatccgg
tcatatatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcagcagatcctggatgaaaagccc
aagctgcagatggacttggagcaagagtaccaagacaagttcaaaagactgcccctggag
atcttggagtttgtgcaggaagccatgaaagggaagatcagtgaagagagcaatcacagt
tctgcccctccctccctggcctcagaccctggaaaactgaaccacaagcctccctccagt
gaggagctagagggagacaacccaggaaaagagtttgatactcctctgtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (61)   
   KEGG PATHWAY (60)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (6)   
   Pfam (6)   
All databases (91)   

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