aromatic 2-oxoacid reductase;
(R)-aromatic lactate dehydrogenase;
fldH (gene name);
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
aromatic 2-oxoacid:NAD+ oxidoreductase
(1) (R)-3-(phenyl)lactate + NAD+ = 3-phenylpyruvate + NADH + H+ [RN:
(2) (R)-3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH + H+ [RN:
(3) (R)-(indol-3-yl)lactate + NAD+ = (indol-3-yl)pyruvate + NADH + H+ [RN:
The enzymes from anaerobic bacteria such as Clostridium sporogenes participate in the fermentation pathways of L-phenylalanine, L-tyrosine and L-tryptophan. The enzyme from the yeast Candida maltosa has similar activity, but, unlike the bacterial enzyme, requires Mn2+ and can also use NADPH with lower activity.
EC 184.108.40.206 created 1972 (EC 220.127.116.11 created 2000, incorporated 2018), modified 2018
ec00960 Tropane, piperidine and pyridine alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
K23109 aromatic 2-oxoacid reductase
Genes » show all
Jean M, DeMoss RD.
Indolelactate dehydrogenase from Clostridium sporogenes.
Giesel H, Simon H
On the occurrence of enoate reductase and 2-oxo-carboxylate reductase in clostridia and some observations on the amino acid fermentation by Peptostreptococcus anaerobius.
Bode, R., Lippoldt, A. and Birnbaum, D.
Purification and properties of D-aromatic lactate dehydrogenase an enzyme involved in the catabolism of the aromatic amino acids of Candida maltosa.
Biochem Physiol Pflanzen 181:189-198 (1986)
Dickert S, Pierik AJ, Linder D, Buckel W
The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes.
Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.
ExPASy - ENZYME nomenclature database: 18.104.22.168