KEGG   ENZYME: 1.1.1.197
Entry
EC 1.1.1.197                Enzyme                                 

Name
15-hydroxyprostaglandin dehydrogenase (NADP+);
NADP-dependent 15-hydroxyprostaglandin dehydrogenase;
NADP-linked 15-hydroxyprostaglandin dehydrogenase;
NADP-specific 15-hydroxyprostaglandin dehydrogenase;
type II 15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase
Reaction(IUBMB)
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+ [RN:R04552]
Reaction(KEGG)
R04552
Substrate
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate [CPD:C04741];
NADP+ [CPD:C00006]
Product
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate [CPD:C04654];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
History
EC 1.1.1.197 created 1984
Orthology
K00079  carbonyl reductase 1
Genes
HSA: 873(CBR1)
PTR: 473983(CBR1)
PPS: 100984486(CBR1)
GGO: 101128365(CBR1)
PON: 100172097(CBR1)
NLE: 100595150(CBR1)
MCC: 699655
MCF: 102141127
CSAB: 103218526(CBR1)
CATY: 105575413(CBR1)
PANU: 101016017(CBR1)
RRO: 104680046
RBB: 108536876(CBR1)
TFN: 117095746
PTEH: 111525655
CJC: 100385429(CBR1)
SBQ: 101053953(CBR1)
MMU: 12408(Cbr1)
MCOC: 116086159
MUN: 110553070
NGI: 103736428(Cbr1)
TUP: 102493488(CBR1)
MLX: 118018856
BTA: 112441473 510180(MGC127133) 515946(CBR1)
CFR: 102513911
CBAI: 105070208
CDK: 105089844
BACU: 103007396
LVE: 103084663(CBR1)
OOR: 101289691(CBR1)
DLE: 111163852
PCAD: 102979665
PSIU: 116753471
MYD: 102773942(CBR1)
MNA: 107533500
HAI: 109391219
DRO: 112304093
SHON: 118983273
AJM: 119035748
PDIC: 114490628
MMF: 118617249
RFQ: 117033746
PALE: 102891228
PGIG: 120598927
PVP: 105295827
RAY: 107499360
TMU: 101361316
SHR: 100920969
OAA: 100081857
GGA: 418512(CBR1)
PCOC: 116241963
MGP: 100550018(CBR1)
CJO: 107323279
NMEL: 110402739
APLA: 101794661
ACYG: 106036138
TGU: 100222525
LSR: 110475373
SCAN: 103815738(CBR1)
PMOA: 120503114
OTC: 121333523
PRUF: 121357711
GFR: 102043656(CBR1)
FAB: 101809650 101821429(CBR1)
PHI: 102114609(CBR1)
PMAJ: 107211649
CCAE: 111928724
CCW: 104696752
FPG: 101915985(CBR1)
FCH: 102057061
CLV: 102094554
EGZ: 104128238
NNI: 104020135
ACUN: 113483093
TALA: 104366735
PADL: 103920269
AAM: 106494985
AROW: 112971825
NPD: 112959067
DNE: 112996142
ASN: 102386516
AMJ: 102575087(CBR1)
CPOO: 109305805
GGN: 109302951
PSS: 102454231
CPIC: 101937374
TST: 117867478
CABI: 116823660
MRV: 120406799
PBI: 103066276
PMUR: 107293983
TSR: 106549473
PGUT: 117679055
VKO: 123029332
GJA: 107119801
XLA: 108707866(cbr1.2.L) 108707867(cbr1.1.L) 108707868 496039(cbr1.1.S) 734804(cbr1.2.S)
XTR: 100145008(cbr1.3) 101735101(cbr1.2) 496612(cbr1.1)
DRE: 337696(cbr1l) 373866(cbr1) 792137
CCAR: 109096114(cbr1)
IPU: 108258607(cbr1) 108279390
PHYP: 113537332(cbr1) 113541450
EEE: 113577487
TRU: 101070504(cbr1)
LCO: 104925597(cbr1)
CGOB: 115019870(cbr1)
ELY: 117271559(cbr1)
PLEP: 121954458(cbr1)
SLUC: 116061672(cbr1)
ECRA: 117960675(cbr1)
PFLV: 114571677 114571914(cbr1)
GAT: 120821041(cbr1)
PPUG: 119214205(cbr1)
CUD: 121510925(cbr1)
OLA: 100125494(cbr1)
OML: 112161544(cbr1)
XMA: 102228388(cbr1) 102228648
GAF: 122842620(cbr1)
CVG: 107105240
CTUL: 119777760(cbr1)
NFU: 107376130 107376131(cbr1)
ALIM: 106527744(cbr1)
CSEM: 103387805(cbr1)
POV: 109644021(cbr1)
SSEN: 122782161(cbr1)
HHIP: 117775513(cbr1)
LCF: 108872922(cbr1)
SDU: 111223859(cbr1)
SLAL: 111645450(cbr1)
XGL: 120796209(cbr1)
MALB: 109963832(cbr1)
ELS: 105010857 109614572(cbr1)
AANG: 118222361(cbr1) 118234863(cbr1l)
LOC: 102683960
ARUT: 117406814(cbr1) 117418842(cbr1l)
LCM: 102349061 102367136(CBR1)
RTP: 109933230(cbr1)
CIN: 100182286
AME: 551072
ACER: 107992424
ALAB: 122712060
BIM: 100747164
BBIF: 117205298
BVAN: 117165055
BTER: 100643942
BPYO: 122571527
MGEN: 117229033
NMEA: 116424066
CGIG: 122403747
SOC: 105207948
MPHA: 105834151
PBAR: 105424036
VEM: 105570263
HST: 105186587
DQU: 106748457
CFO: 105250549
FEX: 115233986
LHU: 105676624
PGC: 109853439
OBO: 105284661
PCF: 106788977
PFUC: 122521985
VPS: 122637488
TCA: 661972
NVL: 108565934
DNX: 107164342
AGS: 114130899
RMD: 113552883
DCI: 103512831
CLEC: 106664003
FOC: 113208263
ZNE: 110840714
PJA: 122260414
HAME: 121858864
HAZT: 108670470
TUT: 107369493
SDM: 118186353
OBI: 106869220
AQU: 100637791
LJA: Lj1g3v4457750.1(Lj1g3v4457750.1) Lj2g3v0126340.1(Lj2g3v0126340.1) Lj4g3v0510200.1(Lj4g3v0510200.1)
DOSA: Os01t0929500-01(Os01g0929500) Os02t0607700-01(Os02g0607700) Os04t0496000-01(Os04g0496000) Os04t0496150-00(Os04g0496150)
SMIN: v1.2.012697.t1(symbB.v1.2.012697.t1) v1.2.027692.t1(symbB.v1.2.027692.t1) v1.2.038435.t1(symbB.v1.2.038435.t1)
MMAG: MMAD_15640
NSR: NS506_05239(cbr1)
SHY: SHJG_1150
SBH: SBI_00264
SALU: DC74_1011
SALL: SAZ_05530
SCYG: S1361_36620(fabG15)
KAL: KALB_4608
 » show all
Reference
1  [PMID:234431]
  Authors
Lee SC, Levine L.
  Title
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.
  Journal
J Biol Chem 250:548-52 (1975)
Reference
2  [PMID:803247]
  Authors
Lee SC, Pong SS, Katzen D, Wu KY, Levine L.
  Title
Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.
  Journal
Biochemistry 14:142-5 (1975)
DOI:10.1021/bi00672a024
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.197
IUBMB Enzyme Nomenclature: 1.1.1.197
ExPASy - ENZYME nomenclature database: 1.1.1.197
BRENDA, the Enzyme Database: 1.1.1.197
CAS: 54989-39-8

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