KEGG   ENZYME: 1.1.1.237
Entry
EC 1.1.1.237                Enzyme                                 
Name
hydroxyphenylpyruvate reductase;
HPPR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03337 R03339];
(2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ = 3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03373 R12252]
Reaction(KEGG)
Substrate
(R)-3-(4-hydroxyphenyl)lactate [CPD:C03964];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
(R)-3-(3,4-dihydroxyphenyl)lactate [CPD:C22038]
Product
3-(4-hydroxyphenyl)pyruvate [CPD:C01179];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
3-(3,4-dihydroxyphenyl)pyruvate [CPD:C04045]
Comment
The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
History
EC 1.1.1.237 created 1992, modified 2018
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13574  hydroxycarboxylate dehydrogenase B
K18606  hydroxyphenylpyruvate reductase
Genes
MINC123219074
PDUL117623493
CMAX111488676
CMOS111456204
CPEP111806905
QLO115992938
SOT102590277
CANN107861824
NTA107815351 107815507
NSY104246687
NTO104089553
NAU109224021
INI109188277
SIND105157644
OEU111367158 111370835
EGT105975669
SSPL121768515 121771586 121795126 121795127 121795132 121795133 121797828
ECAD122588587 122595340 122596024
LSV111910276 111910278
DCR108209340
CSIN114279513 114323921
BVG104904687
NNU104595178
MING122066597 122066860 122082675 122082676
TSS122653576 122666837 122667233
PSOM113348278 113349087
NCOL116255569
ECOb0801(hcxB)
ECJJW0786(ybiC)
ECDECDH10B_0869(ybiC)
EBWBWG_0654(ybiC)
ECOKECMDS42_0651(ybiC)
ECEZ1022(ybiC)
ECSECs_0879(ybiC)
ECFECH74115_0950
ETWECSP_0898(ybiC)
ELXCDCO157_0857
EOIECO111_0862(ybiC)
EOJECO26_0924(ybiC)
EOHECO103_0837(ybiC)
ECOOECRM13514_0878(ybiC)
ECOHECRM13516_0833(ybiC)
ESLO3K_17345
ESOO3O_07945
ESMO3M_17315
ECKEC55989_0845(ybiC)
ECGE2348C_0753(ybiC)
EOKG2583_1029(ybiC)
ELRECO55CA74_04995
ELHETEC_0868
ECWEcE24377A_0869
EUNUMNK88_841
ECPECP_0815
ENAECNA114_0734(ybiC)
ECOSEC958_0914(ybiC)
ECVAPECO1_1289(ybiC)
ECOAAPECO78_07675
ECXEcHS_A0856
ECMEcSMS35_0825
ECYECSE_0857
ECRECIAI1_0839(ybiC)
ECQECED1_0766(ybiC)
EUMECUMN_0945(ybiC)
ECTECIAI39_0778(ybiC)
EOCCE10_0822(ybiC)
EBRECB_00768(ybiC)
EBLECD_00768(ybiC)
EBEB21_00785(ybiC)
EBDECBD_2822
ECIUTI89_C0804(ybiC)
EIHECOK1_0804
ECZECS88_0819(ybiC)
ECCc0885(ybiC)
ELOEC042_0891
ELNNRG857_03580
ESEECSF_0727
ECLEcolC_2842
EKOEKO11_3085
EKFKO11_19775(ybiC)
EABECABU_c08430(ybiC)
EDHEcDH1_2841
EDJECDH1ME8569_0754(ybiC)
ELUUM146_13640
ELWECW_m0857(ybiC)
ELLWFL_04165(ybiC)
ELCi14_0850(ybiC)
ELDi02_0850(ybiC)
ELPP12B_c0790(ybiC)
ELFLF82_2638(ybiC)
ECOLLY180_04220
ECOIECOPMV1_00803(ybiC)
ECOJP423_03975
EFEEFER_2307(ybiC)
EALEAKF1_ch0669c
EMAC1192_08315
ESZFEM44_18510
SFLSF0751(ybiC)
SFXS0792(ybiC)
SFVSFV_0784(ybiC)
SFESFxv_0817(ybiC)
SFNSFy_1020
SFSSFyv_1062
SFTNCTC1_00758(ybiC)
SSNSSON_0780(ybiC)
SBOSBO_0689(ybiC)
SBCSbBS512_E2551
SDYSDY_0798(ybiC)
SDZAsd1617_01003
SHQA0259_07955
KPNKPN_02089
KPUKP1_3177
KPMKPHS_30690
KPPA79E_2154
KPHKPNIH24_13095
KPZKPNIH27_14700
KPVKPNIH29_15355
KPWKPNIH30_15635
KPYKPNIH31_14490
KPGKPNIH32_15530
KPCKPNIH10_15160
KPQKPR0928_15135
KPTVK055_0373
KPOKPN2242_13400
KPRKPR_2631(ybiC)
KPJN559_2201
KPID364_10710
KPAKPNJ1_02376
KPSKPNJ2_02334
KPXPMK1_04453(ybiC)
KPBFH42_06540
KPNEKU54_010985
KPNULI86_10940
KPNKBN49_3194(ybiC)
KVAKvar_2185
KPEKPK_2241
KPKA593_25410
KVDKR75_23335
KVQSP68_04050
KOXKOX_18735 KOX_22540
KOEA225_2618 A225_3382
KOYJ415_15110 J415_18885
KOMHR38_17100 HR38_20840
KOKKONIH1_12525 KONIH1_16575
KOCAB185_19325
KQUAVR78_19520
EAEEAE_17445
EARCCG30404
KQVB8P98_11955
KLLBJF97_16700
KLWDA718_12245
KARLGL98_10470
KGRJJJ10_12210
RORRORB6_04420
RONTE10_17060
RPLNB1209_11075
RAODSD31_10850
RTGNCTC13098_02582(ybiC_1) NCTC13098_03134(ybiC_2)
REEelectrica_01980(ybiC_1) electrica_02154(ybiC_2)
CKOCKO_02080
CFDCFNIH1_14120
CBRAA6J81_08975
CWECO701_14780
CYOCD187_16155
CPOTFOB25_03655
CFQC2U38_08175
CIFAL515_08610
CIEAN232_22325
CPARCUC49_03815
CITZE4Z61_00990
CARSE1B03_09210
CEMLH23_17850
PGELG71_13660
KORAWR26_07420
KRDA3780_16540
SYMK6K13_11430
METYMRY16398_29140(ybiC) MRY16398_42030
AHNNCTC12129_02563(ybiC)
ASUBNLZ15_11070
KINAB182_12390 AB182_18530
PDZHHA33_15075 HHA33_21005
IZHFEM41_12230
EBCC2U52_23280 C2U52_29745
EBUCUC76_00540
PSTSE05_07330
SMARSM39_1490
SMACSMDB11_1291
SMWSMWW4_v1c20410(ybiC)
SPESpro_2010
SRRSerAS9_1961
SRLSOD_c18420(ybiC)
SRYM621_10145
SPLYQ5A_010085(ybiC)
SRSSerAS12_1961
SRASerAS13_1962
SMAFD781_1855
SLQM495_09840
SRZAXX16_3279
SERASer39006_011830
SERQCWC46_11825
SERMCLM71_09250
SQUE4343_06090
SFJSAMEA4384070_2085(ybiC_2)
SOFNCTC11214_04882(ybiC)
SSURATE40_006730
SURIJ0X03_13805
SRHZFO014_00575
SENPKHA73_10260
GQUAWC35_00900 AWC35_03550
ECAECA1527
PATREV46_07725
PATOGZ59_15650
PCTPC1_1400 PC1_1845
PCCPCC21_019060
PCVBCS7_07065
PWAPecwa_1798 Pecwa_2132
PPARA8F97_08210 A8F97_09785
PECW5S_1712 W5S_2077
PWSA7983_18130 A7983_22515
PPOABJK05_02250 BJK05_04260
PBRAB5S52_12455
PPUJE2566_09885
PARII2D83_10070 I2D83_14995
PVZOA04_24140 OA04_28810
DDDDda3937_02253 Dda3937_02692
DZEDd1591_1632
DDCDd586_1595
DZCW909_12045
DSOA4U42_00945 A4U42_16640
CEDLH89_04530 LH89_21165
DFNCVE23_08230 CVE23_13820
DDQDDI_1237 DDI_2492
DAQDAQ1742_02832
DICDpoa569_001506 Dpoa569_002383
DDADd703_1300 Dd703_1601
BGJAWC36_08580 AWC36_10535
BRBEH207_11335
BNGEH206_12170 EH206_14470
BIZHC231_09955
LBQCKQ53_11480
LPOPI6N93_06705
SLIGGTU79_18870
EPECI789_12735
ERPLJN55_06005
PAOPat9b_1046
KLNLH22_16995
PANSFCN45_05475
TCIA7K98_05900
GAIIMCC3135_12715(ybiC)
LLPGH975_03415
LHKLHK_00733
PSENH8B_1101
VOGLCH97_00155
RPJN234_10685
REHH16_B0942(h16_B0942)
CNCCNE_2c09100
CUHBJN34_25865
REUReut_A1498
RMERmet_1634(ybiC)
CTIRALTA_B0766
CBWRR42_s1740
CGDCR3_3549(ybiC)
CCUPBKK81_30325
CUPBKK80_26030
CUUBKK79_31905
CPAUEHF44_13540
COXE0W60_18040
CCAMM5D45_08140
BVIBcep1808_5437
BVEAK36_3467
BURBcep18194_B0783
BCMBcenmc03_5376
BCHBcen2424_4910
BCJBCAM2148
BCENDM39_5704
BCEWDM40_4867
BCEOI35_6030
BAMBamb_4341
BACBamMC406_4858
BMJBMULJ_04813(ybiC)
BMUBmul_3704
BMKDM80_5086
BMULNP80_4847
BCTGEM_3531
BCEDDM42_5847
BCEPAPZ15_28390
BDLAK34_3599
BPYRABD05_24720
BCONNL30_01730 NL30_16180
BDFWI26_23635
BLATWK25_26805
BTEIWS51_07850
BSEMWJ12_30605
BPSLWS57_03400
BMECWJ16_29210
BSTGWT74_29735
BSTLBBJ41_24285
BANNJFN94_28665
BUGBC1001_3756
BYIBYI23_B006540
BUKMYA_5051
BUEBRPE67_BCDS08850
BUQAC233_20755
BUMAXG89_21570
BUIAX768_24100
BURKDM992_22225
BPHBphy_5277
BGEBC1002_4042
BPXBUPH_00322
BPYBphyt_5456
BCAIK788_0002937
PSPWBJG93_25975
PARABTO02_06355
PHSC2L64_24685
PTERC2L65_23600
PGPCUJ91_22670
PCJCUJ87_22265
PTSCUJ90_29855
PMEGFNZ07_00650
PGISI6I06_23935
PACPFAZ97_24460
PACSFAZ98_22870
PEWKZJ38_17700
CABASBC2_58360(hcxB)
BUOBRPE64_BCDS06860(ybiC)
BFZBAU07_03380
BOZDBV39_18870
RHYRD110_04390
RHFEUB48_18815
POLBpro_3968
POSDT070_03385
PVACHC248_02881(hcxB_2)
VEIVeis_1530
VAPVapar_0782
VPEVarpa_0800
VPDVAPA_1c08430
VAAAX767_07380
VBOCKY39_03955
VAMC4F17_15290
RTARta_08970
LIML103DPR2_00626(ybiC)
LIHL63ED372_02625(ybiC)
SUTTSUTMEG_20000
SUTKFG381_06190
SWSI6J16_00030
MLOmlr9117
BJAbll2917(bll2917)
BJUBJ6T_67890 BJ6T_68480
BJPRN69_32930 RN69_33220
BRABRADO2597
BBTBBta_2943
BRSS23_50980
AOLS58_50150
BRCBCCGELA001_13060 BCCGELA001_13315
BRADBF49_1720 BF49_1774
BICLMTR13_28430
BROBRAD285_4739
BRKCWS35_18135
BOTCIT37_39020
BRQCIT40_09065
BGQX265_26365
BGZXH91_24600
BSYMCIT39_08165 CIT39_08460
BBETF8237_05505
BARHWN72_16000
BVZBRAD3257_5784(ybiC)
BELBE61_70620
BDGLPJ38_17615 LPJ38_17875
BSEPHAP48_0030810
BQBJ4P68_0032070
RPARPA3756
RPBRPB_1710
RPCRPC_1699
RPDRPD_3587
RPTRpal_4277
RPXRpdx1_1587
RBKE0H22_18025
VGOGJW-30_1_02181(ybiC)
TRBHB776_13875
BOPAXW83_07660
BOSBSY19_2656
BVVBHK69_19355
BOIBLM15_06645
BOFFQV39_04075
STARG3545_25755
MRDMrad2831_3061
METM446_6488
MNOMnod_6588
MORMOC_3439
MAQUMaq22A_c16540
MPHYMCBMB27_02475
MEEDA075_22540
METXA3862_16640
MMESMMSR116_15560
MTEADK419_16250
MINDmvi_46040
MTADM6G65_32955
MOCBB934_16735
RHJHZY79_01380
PSINCAK95_00185
RBMTEF_07945 TEF_09375
PHRC6569_08080
PSTGE8M01_33730
SILSPO1603
LEJETW24_04545
SPOTG6548_05185
MMRMmar10_0711
HYTHXX25_01495
ZMPZymop_1077
RGIRGI145_06295
ROSCTJ15_11105
RMUCFOB66_08110
RMTIAI58_14260
SRFLHU95_03030 LHU95_11910
RAPRHOA_0566(hcxB) RHOA_1359(hcxB)
SHUMSTHU_18420 STHU_40300 STHU_51190
SVCSTVA_34900 STVA_51100
STELSTAQ_17320 STAQ_46330
AZLAZL_a00760 AZL_a06180
ALIAZOLI_p20546
ABSAZOBR_p130099(ldh)
ABQABAZ39_18425
ABFAMK58_16305
ATIAL072_27750
AZTTSH58p_29005
AZMDM194_19645 DM194_22170
AZZDEW08_01245
SKTIGS68_02365
SMUCJL100_002470
SROEJL101_023045
TMOTMO_0662(ybiC)
FERFNB15_01600
ELIOKO353_01085 KO353_03675 KO353_05605
NACINUH88_01885 NUH88_11400
SNEANBZ79_18745
ASOIMTP13_14750
DNIHX89_07150
ARSADJ73_10745
PDXPsed_6328
PSUUPsuf_086470
VERHUT12_13325
HALGHUG10_07180
 » show all
Reference
1
  Authors
Petersen, M. and Alfermann, A.W.
  Title
Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.
  Journal
Z Naturforsch C: Biosci 43:501-504 (1988)
Reference
2  [PMID:15284489]
  Authors
Kim KH, Janiak V, Petersen M
  Title
Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei.
  Journal
Plant Mol Biol 54:311-23 (2004)
DOI:10.1023/B:PLAN.0000036367.03056.b2
  Sequence
Reference
3  [PMID:25918800]
  Authors
Kim YB, Uddina MR, Kim Y, Park CG, Park SU
  Title
Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria  baicalensis.
  Journal
Nat Prod Commun 9:1311-4 (2014)
Reference
4  [PMID:29329649]
  Authors
Wang GQ, Chen JF, Yi B, Tan HX, Zhang L, Chen WS
  Title
HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza.
  Journal
Chin J Nat Med 15:917-927 (2017)
DOI:10.1016/S1875-5364(18)30008-6
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.237
IUBMB Enzyme Nomenclature: 1.1.1.237
ExPASy - ENZYME nomenclature database: 1.1.1.237
BRENDA, the Enzyme Database: 1.1.1.237
CAS: 117590-77-9

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