The enzyme is highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 22.214.171.1249
, 2-(S)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (S)-enantiomer. This enzyme forms component III of a four-component enzyme system (comprising EC 126.96.36.199
[2-hydroxypropyl-CoM lyase; component I], EC 188.8.131.52
[2-oxopropyl-CoM reductase (carboxylating); component II], EC 184.108.40.2068
[2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 220.127.116.119
[2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.