KEGG   ENZYME: 1.1.1.270
Entry
EC 1.1.1.270                Enzyme                                 
Name
3beta-hydroxysteroid 3-dehydrogenase;
3-keto-steroid reductase;
3-KSR;
HSD17B7 (gene name);
ERG27 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3beta-hydroxysteroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ [RN:R12402]
Reaction(KEGG)
Substrate
3beta-hydroxysteroid [CPD:C02945];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].
History
EC 1.1.1.270 created 2002, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09827  3-keto steroid reductase
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
K22970  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA51478(HSD17B7) 79154(DHRS11)
PTR454598(DHRS11) 466046 747814(HSD17B7)
PPS100985156 100989828(DHRS11) 117974256(HSD17B7)
GGO101133645(DHRS11) 101137638(HSD17B7)
PON100446761(HSD17B7) 100450428(DHRS11)
NLE100580130(DHRS11) 100587120(HSD17B7)
MCC713823(DHRS11) 720399
MCF102127673(HSD17B7) 102133734(DHRS11)
MTHB126939340
CSAB103223654(HSD17B7) 103242795(DHRS11)
CATY105583369(DHRS11) 105589219(HSD17B7)
PANU101007886(DHRS11) 101019563(HSD17B7)
TGE112610332(DHRS11)
RRO104656967(HSD17B7) 104672997(DHRS11)
RBB108526295(DHRS11) 108535633
TFN117067355(DHRS11) 117074787(HSD17B7)
PTEH111525046(HSD17B7) 111537680(DHRS11)
CJC100410416(HSD17B7) 100415468(DHRS11)
SBQ101047238(HSD17B7) 101049784(DHRS11)
CSYR103250515(HSD17B7) 103269368(DHRS11)
MMUR105873582(HSD17B7) 105879451(DHRS11)
LCAT123620379(DHRS11) 123635243(HSD17B7)
OGA100950944(DHRS11) 100957601(HSD17B7)
MMU15490(Hsd17b7) 192970(Dhrs11)
MCAL110292934(Hsd17b7) 110304998(Dhrs11)
MPAH110322287(Hsd17b7) 110332326(Dhrs11)
RNO29540(Hsd17b7) 360583(Dhrs11)
MCOC116078372(Dhrs11) 116103156(Hsd17b7)
MUN110550630(Hsd17b7) 110555253(Dhrs11)
CGE100763193(Dhrs11) 100767580(Hsd17b7)
MAUA101828473(Dhrs11) 101836885(Hsd17b7)
PLEU114689903(Hsd17b7) 114707715(Dhrs11)
MORG121441976 121455259 121457070(Dhrs11)
MFOT126487000 126511195
AAMP119813383(Dhrs11) 119827319(Hsd17b7)
NGI103732605(Dhrs11) 103746788(Hsd17b7)
HGL101704213(Dhrs11) 101712707(Hsd17b7)
CPOC100729809(Hsd17b7) 100733505(Dhrs11)
CCAN109690973(Hsd17b7) 109691233(Dhrs11)
DORD105983235(Dhrs11) 105989680(Hsd17b7) 106002656
DSP122103721(Hsd17b7) 122119919(Dhrs11)
NCAR124980099 124990069
OCU100008778(HSD17B7) 100349261 100350282(DHRS11)
OPI101524723(HSD17B7) 101526339(DHRS11)
TUP102473205(HSD17B7) 102481007(DHRS11)
CFA491129(DHRS11) 609364(HSD17B7)
CLUD112643059(HSD17B7) 112655062(DHRS11)
VVP112914306(HSD17B7) 112917964(DHRS11)
VLG121473558(DHRS11) 121501279(HSD17B7)
AML100477716(HSD17B7) 100483445(DHRS11)
UMR103658287(HSD17B7) 103667445(DHRS11)
UAH113268675(HSD17B7) 113268922(DHRS11)
UAR123776919(DHRS11) 123800151(HSD17B7)
ELK111151061 111151673
LLV125086086 125086982
MPUF101688526(DHRS11) 101689203(HSD17B7)
ORO101368538(HSD17B7) 101372465(DHRS11)
EJU114210516(HSD17B7) 114213877(DHRS11)
ZCA113933397(HSD17B7) 113936410(DHRS11)
MLX118014038(HSD17B7) 118025129(DHRS11)
NSU110588123(HSD17B7) 110592971(DHRS11)
FCA101083482(HSD17B7) 101083724(DHRS11)
PYU121017066(DHRS11) 121020915(HSD17B7)
PBG122475607(HSD17B7) 122485272(DHRS11)
LRUF124509916 124512930
PTG102953856(DHRS11) 102968316(HSD17B7)
PPAD109251987(DHRS11) 109276652(HSD17B7)
AJU106980443(DHRS11) 106986761(HSD17B7)
HHV120241069(HSD17B7) 120248116(DHRS11)
BTA505212(HSD17B7) 510264(DHRS11)
BOM102266348(HSD17B7) 102267490(DHRS11)
BIU109574096(DHRS11) 109577890(HSD17B7)
BBUB102389083(HSD17B7) 102414485(DHRS11)
CHX102176160(DHRS11) 102179058(HSD17B7)
OAS101109465(DHRS11) 101110013(HSD17B7)
ODA120855521(HSD17B7) 120866412(DHRS11)
CCAD122429981(HSD17B7) 122432561 122449929(DHRS11)
SSC100155418(HSD17B7) 100513307(DHRS11)
CFR102507556(DHRS11) 102512546(HSD17B7)
CBAI105064308(DHRS11) 105068038(HSD17B7)
CDK105092702(HSD17B7) 105097850(DHRS11)
VPC102531229(HSD17B7) 102531560(DHRS11)
BACU103011691(DHRS11) 103014331(HSD17B7)
LVE103069867(DHRS11) 103084050(HSD17B7)
OOR101278328(DHRS11) 101286750(HSD17B7)
DLE111163734(DHRS11) 111169243(HSD17B7)
PCAD102984493(HSD17B7) 102995379(DHRS11)
PSIU116743840(HSD17B7) 116746440(DHRS11)
ECB100059061(HSD17B7) 100071416(DHRS11)
EPZ103554456(DHRS11) 103559639(HSD17B7)
EAI106823694(HSD17B7) 106844689(DHRS11)
MYB102251181(HSD17B7) 102262752(DHRS11)
MYD102765268(DHRS11) 102767046(HSD17B7)
MMYO118671682(DHRS11) 118673077(HSD17B7)
MLF102428751(HSD17B7) 102439019(DHRS11)
MNA107530816(DHRS11) 107535110(HSD17B7)
PKL118712029(HSD17B7) 118726466(DHRS11)
HAI109379798(DHRS11) 109392309(HSD17B7)
DRO112298817(HSD17B7) 112316505(DHRS11)
SHON118979201(HSD17B7) 119003587(DHRS11)
AJM119052313(HSD17B7) 119062640(DHRS11)
PDIC114502689(DHRS11) 114511975(HSD17B7)
PHAS123817235(DHRS11) 123818535(HSD17B7)
MMF118633927(DHRS11) 118637572(HSD17B7)
RFQ117013304(DHRS11) 117015421(HSD17B7)
PALE102892079(HSD17B7) 102894290(DHRS11)
PGIG120584178(HSD17B7) 120620857(DHRS11)
PVP105303413(HSD17B7) 105305000(DHRS11)
RAY107510114(DHRS11)
MJV108383263(DHRS11) 108396655(HSD17B7)
TOD119231930(DHRS11) 119241348(HSD17B7)
SARA101551054(HSD17B7) 101551118(DHRS11)
LAV100676060 100676239(DHRS11) 100676343(HSD17B7)
TMU101350976 101361551
DNM101418508(HSD17B7) 101420664(DHRS11)
MDO100016071(HSD17B7) 100618596(DHRS11)
GAS123243907(DHRS11) 123244846(HSD17B7)
SHR100926227(HSD17B7) 100933320(DHRS11)
PCW110209887(HSD17B7) 110212020(DHRS11)
OAA100077820(DHRS11) 114817513(HSD17B7)
GGA395172(DHRS11) 424367(HSD17B7)
PCOC116227942(DHRS11) 116230531(HSD17B7)
MGP100542399(DHRS11) 100542640(HSD17B7)
CJO107317140(HSD17B7) 107322636(DHRS11)
NMEL110402344(HSD17B7)
APLA101796287(DHRS11) 101799136(HSD17B7)
ACYG106041628(HSD17B7) 106046860(DHRS11)
AFUL116491836(HSD17B7) 116497443(DHRS11)
TGU100222823(HSD17B7) 100230987(DHRS11)
LSR110467717(DHRS11) 110478897(HSD17B7)
SCAN103820184(DHRS11) 103824326(HSD17B7)
PMOA120497588(HSD17B7) 120507831(DHRS11)
OTC121344332(HSD17B7) 121347083(DHRS11)
PRUF121359833(HSD17B7) 121361824(DHRS11)
GFR102031952(DHRS11) 102042580(HSD17B7)
FAB101806967(DHRS11) 101818521(HSD17B7)
PHI102107312(HSD17B7) 102113937(DHRS11)
PMAJ107198613(HSD17B7) 107213026(DHRS11)
CCAE111932684(HSD17B7) 111937859(DHRS11)
CCW104690988(DHRS11) 104695594(HSD17B7)
CBRC103612739(HSD17B7) 103613383(DHRS11)
ETL114057489(DHRS11) 114067481(HSD17B7)
ZAB102061622(DHRS11) 102069841(HSD17B7)
ACHL103806603(DHRS11) 103807871(HSD17B7)
FPG101912846(DHRS11) 101919410(HSD17B7)
FCH102050282(DHRS11) 102059217(HSD17B7)
CLV102090168(DHRS11) 102097738(HSD17B7)
EGZ104121871(DHRS11) 104132130(HSD17B7)
NNI104010459(HSD17B7) 104016400(DHRS11)
PLET104614462(HSD17B7) 104619859(DHRS11)
PCRI104034337(DHRS11) 104034394(HSD17B7)
PCAO104043476(HSD17B7) 104052672(DHRS11)
ACUN113483111(HSD17B7) 113487258(DHRS11)
TALA104356976(HSD17B7) 104360740(DHRS11)
PADL103914076(HSD17B7) 103917037(DHRS11)
AFOR103898043(DHRS11) 103904020(HSD17B7)
ACHC115347497(DHRS11) 115349487(HSD17B7)
HALD104314838(HSD17B7) 104315802(DHRS11)
CCRI104155453(HSD17B7) 104156066(DHRS11)
CSTI104549393(HSD17B7) 104559481(DHRS11)
EHS104510302(DHRS11) 104516764(HSD17B7)
CMAC104474625(DHRS11) 104482200(HSD17B7)
MUI104533594(HSD17B7) 104539474(DHRS11)
FGA104078589(HSD17B7) 104082797(DHRS11)
GSTE104258108(DHRS11) 104260822(HSD17B7)
LDI104340165(HSD17B7) 104343602(DHRS11)
MNB103769161(HSD17B7) 103780383(DHRS11)
OHA104329421(DHRS11) 104333725(HSD17B7)
NNT104399910(HSD17B7) 104404606(DHRS11)
DPUB104307784(DHRS11) 104307990(HSD17B7)
PGUU104458613(HSD17B7) 104461659(DHRS11)
ACAR104518582(HSD17B7) 104525116(DHRS11)
AVIT104268103(HSD17B7) 104276911(DHRS11)
CVF104291882(DHRS11) 104293312(HSD17B7)
CUCA104054748(HSD17B7) 104064969(DHRS11)
AAM106494687(DHRS11) 106499711(HSD17B7)
AROW112968787(DHRS11) 112977170(HSD17B7)
NPD112951140(HSD17B7) 112954713(DHRS11)
TGT104567919(DHRS11) 104581010(HSD17B7)
DNE112987422(DHRS11) 112997417(HSD17B7)
SCAM104140832(HSD17B7)
ASN102374189(HSD17B7) 112551119(DHRS11)
AMJ102561890(DHRS11) 102565865(HSD17B7)
CPOO109307069(HSD17B7) 109317147(DHRS11)
GGN109287068(HSD17B7) 109293262(DHRS11)
PSS102452802(DHRS11) 102461698(HSD17B7)
CMY102944731(HSD17B7) 102944881(DHRS11)
CPIC101936463(DHRS11) 101953232(HSD17B7)
TST117867488(DHRS11) 117881449(HSD17B7)
CABI116824223(DHRS11) 116831149(HSD17B7)
MRV120370584(HSD17B7) 120387076(DHRS11)
ACS100556465(hsd17b7)
PVT110075560(DHRS11) 110081655(HSD17B7)
SUND121929890(HSD17B7)
PBI103063132(HSD17B7) 103065679(DHRS11)
PMUR107294873(DHRS11) 107302880(HSD17B7)
CTIG120310515(HSD17B7) 120310987(DHRS11)
TSR106539066(DHRS11)
PGUT117661207(HSD17B7) 117675673(DHRS11)
VKO123023595(DHRS11) 123027952(HSD17B7)
PMUA114585448(DHRS11) 114598525(HSD17B7)
ZVI118078620 118089365(HSD17B7) 118097242(DHRS11)
GJA107108933(DHRS11) 107121042(HSD17B7)
STOW125425213 125425220 125433115(HSD17B7)
XLA108704561(dhrs11.L) 495296(dhrs11.S) 734717(hsd17b7.S)
XTR496708(dhrs11) 548963(hsd17b7)
NPR108801354(HSD17B7)
RTEM120945526(HSD17B7)
BBUF120979196(HSD17B7)
BGAR122943861(HSD17B7)
DRE436969(dhrs11b.2) 768185(hsd17b7) 791578(dhrs11a) 791770(dhrs11b.1)
SRX107724130 107724135 107725165 107731464 107734374 107752375 107752377 107758362 107758673 107758683
SANH107654319 107665172 107672389 107672391 107672392 107683210 107684349(hsd17b7) 107692446 107694033
SGH107551038 107562199 107582609 107582610 107591475 107592755 107592792 107594628
CCAR109066392 109066456 109067119 109091408
CAUA113051185 113058281 113068034 113070053 113073543 113100989 113115232
PPRM120460132(hsd17b7) 120471601(dhrs11a) 120471622 120478528 120478530
MAMB125249621 125249622 125249623 125249624 125249625 125249628 125266309(dhrs11a) 125274024(hsd17b7)
IPU108260417(dhrs11a) 108271889(hsd17b7)
PHYP113531061(dhrs11) 113538418(hsd17b7)
SMEO124379484(dhrs11a) 124388015(hsd17b7)
TFD113634115(dhrs11a) 113647617(hsd17b7)
AMEX103021948 103023849 103035681(hsd17b7) 103042381 103042688 103043000
EEE113570462(hsd17b7) 113577576(dhrs11)
TRU101072277 101075534 101079626(hsd17b7) 101079674(dhrs11) 115248690
TNGGSTEN00016280G001 GSTEN00024682G001 GSTEN00030120G001
LCO104923446(dhrs11) 104925933 104930791 104933511
NCC104948248(hsd17b7) 104963923(dhrs11) 104967182 104967580
CGOB115007156(hsd17b7) 115017925 115018914(dhrs11)
ELY117253561(hsd17b7) 117260047 117268096(dhrs11a) 117271615
EFO125888937 125895999(hsd17b7) 125898571(dhrs11a) 125902137
PLEP121940863(hsd17b7) 121943315 121951731 121952976(dhrs11a) 121963835
SLUC116045810 116048477 116058070(dhrs11a) 116063209(hsd17b7)
ECRA117942184 117950534(hsd17b7) 117954002 117955964(dhrs11a)
ESP116674109 116696129 116698600(hsd17b7) 116700528(dhrs11)
PFLV114553336 114561703 114565046 114566471(dhrs11)
GAT120816127(hsd17b7) 120822622(dhrs11a)
PPUG119202648(hsd17b7) 119215510(dhrs11a) 119216850
MSAM119882883 119895317(dhrs11a) 119900960(hsd17b7) 119902362
CUD121511992(hsd17b7) 121516037 121516905 121518057 121518430(dhrs11a) 121520534 121521235 121521242
ALAT119010615 119028523(hsd17b7) 119031909(dhrs11a) 119033593
MZE101475164(dhrs11) 101475712 101476044 101480987 101482452 101483095 106674540 106675057 106675058 112430056 112435947
ONL100694215 100694479 100695275 100695806 100696595 100698653 100698819 100698923 100699728 100701254 100706590(dhrs11) 100708654 102082640 106097863 109194269 112841634
OAU116313876 116313883 116316375 116316390 116318426 116321239 116321691(dhrs11a) 116326992 116327922(hsd17b7) 116331994 120432826 120443504 120443558 120443559 120443560 120443564
OLA101156119 101158433 101160498 101167642(dhrs11)
OML112138999(dhrs11a) 112147206 112149002 112150931(hsd17b7)
XMA102219736(dhrs11) 102223080(hsd17b7) 102225591 102238341 102238369
XCO114133176 114133177 114146459 114150325 114153301(dhrs11)
XHE116708005 116708105 116708307 116721503 116725522 116728461(dhrs11)
PRET103463731 103474141 103474142 103476050(dhrs11) 103479029
PFOR103133850(dhrs11) 103139996 103148525 103155178
PLAI106946498 106949687 106952787 106956657(dhrs11)
PMEI106907488 106917775 106922829 106933207(dhrs11)
GAF122832192 122832193 122838419(hsd17b7) 122840633 122845217(dhrs11a)
CVG107082613 107090012 107090028 107090353(dhrs11) 107099593
CTUL119789912 119790042(hsd17b7) 119791476(dhrs11a) 119795338 119795346
GMU124866110 124870458 124873591(hsd17b7) 124876497(dhrs11a) 124880193 124880948 124883585 124884217 124884218 124884265
NFU107379993 107379994 107384420 107387055(dhrs11) 107393363
KMR108230837(hsd17b7) 108233843(dhrs11a) 108235955 108236012 108236013 108238258 108247279
ALIM106511588 106525408(dhrs11) 106528419(hsd17b7) 106528841 106529742
NWH119407462(hsd17b7) 119411326 119411327 119414502 119420614(dhrs11a)
AOCE111563582 111567499 111567500 111572719(dhrs11) 111580065 111586999
MCEP125009772(hsd17b7) 125011278 125014138 125014139 125021225(dhrs11a)
CSEM103376747 103394917(dhrs11) 103395808
POV109625649(hsd17b7) 109628284(dhrs11) 109644359
SSEN122779439(dhrs11a) 122780473 122780509(hsd17b7)
HHIP117760842(hsd17b7) 117774058(dhrs11a) 117778754
HSP118118430 118121021(hsd17b7) 118122571(dhrs11a)
LCF108875972 108876053 108879148 108883797 108893892(dhrs11a)
SDU111222241(dhrs11) 111228986 111231932 111232315
SLAL111650668 111653771 111663897(dhrs11) 111670521
XGL120790306(hsd17b7) 120792442 120798840 120803065(dhrs11a)
HCQ109521128 109521129 109531160(dhrs11) 109532086
BPEC110163629 110165106(dhrs11) 110173518(hsd17b7) 110174039
MALB109951354(hsd17b7) 109960466(dhrs11) 109966957
BSPL114844067(hsd17b7) 114868694 114869112(dhrs11a)
SASA100196011(dhr11) 106567994 106568727 106603495
STRU115148835 115154304 115156632 115163408
OTW112228556 112257875 112260221(hsd17b7) 112265505
OMY110507750 110530031(hsd17b7) 110533618 110537508
OGO123993925 123994594 124000655 124009932(hsd17b7)
ONE115105516 115114123(hsd17b7) 115135930 115137610
SALP111950509 111957119(hsd17b7) 111981656 111982530
SNH120018199 120030392 120055749(hsd17b7) 120057046
CCLU121573530 121580208 121580679
ELS105024805 105025666(dhrs11) 105030986
SFM108921710(dhrs11) 108935177(hsd17b7) 108938265
PKI111841069(hsd17b7) 111854721(dhrs11) 111859701
AANG118209261 118230844(hsd17b7) 118236726(dhrs11a)
LOC102694052(dhrs11) 102696390(hsd17b7)
PSPA121308431(dhrs11a) 121327382
ARUT117400178 117416602 117429929 117430868
LCM102348492(HSD17B7) 102362545(DHRS11)
CMK103180036(hsd17b7) 103180635(dhrs11a)
RTP109920236(dhrs11) 109925128(hsd17b7)
BFO118408332 118408333 118408418 118421569 118421586 118426285
BBEL109467187 109467200 109482730 109482774
CIN100175937 100179068 100180521 100183772 104266129 104266131 104266156
SCLV120325859 120336480 120346622
SPU574625 574750 574825 588363 752858
APLC110976300 110976571 110976608 110976634 110976654 110976655 110976666
SKO100374990 100375140 100375283 102804082
RZE108380627
ACER107993351
BBIF117205728
BVK117230776
BVAN117157352
NMEA116424013
CGIG122405241
FEX115240720
PFUC122523913
CCIN107266625
CSET123307195
PPYR116171680
OTU111415407 111416771 111420830 111423098
HHAL106680119 106680121 106687257 106687260 106687261 106687264 106691770 106691802 112210398
NLU111054592 111054596 111054598
CSEC111867801 111868321 111868327 111873476 111873478 111873484 111873485 111873486 111873934 111875540 111875546
FCD110845300 110848537
DPXDAPPUDRAFT_306348
DMK116930984
PVM113817572 113823180
PJA122245754 122247374
PCHN125046859 125046860
HAME121862366 121865924
PCLA123767671 123767673 123767674 123767675
PTRU123515477 123515543 123515544 123515545 123515937 123515938
LSM121116144 121122687 121123209
PPOI119090724 119090775 119092040 119105906 119107105 119107124 119112263 119112466 119112985
CSCU111616124 111618745 111618759
PTEP107437425
SDM118180812 118195543
HROHELRODRAFT_76698
LGILOTGIDRAFT_201976 LOTGIDRAFT_205793
PCAN112561798 112564142 112575325
BGT106062648 106063212
GAE121366783 121376023 121380252 121381187
HRF124113772 124114009 124114011 124114013 124114014 124143791 124146728 124146756
HRJ124260971 124264874 124288111 124288131 124288132
CRG105331538 105332739 105338891 117680536
MYI110447365 110457107
PMAX117328501 117328541 117343915
MMER123524121 123531642 123531798
OBI106869005 106869006
OSN115223516 115223538 115223587 115231651
LAK106150742 106152479 106155453 106155948 106155949 106155960 106157462 106158358 106160574 106162367 106165644 106166261 106166737 106167094 106170933 106170936 106176414
TADTRIADDRAFT_53215
AQU100632069 100632185 100633565 100638506 100640506
QSU111993502 112014247
SCEYLR100W(ERG27)
SEUBDI49_3627
SPAOSPAR_L01540
AGOAGOS_AGR068W
ERCEcym_4279
KLAKLLA0_F19756g
KMXKLMA_40163(ERG27)
LTHKLTH0G13046g
VPOKpol_1033p20
ZROZYRO0D06534g
CGRCAGL0M11506g
NCSNCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDINDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPFTPHA_0C01040(TPHA0C01040)
TBLTBLA_0D04010(TBLA0D04010)
TDLTDEL_0F04160(TDEL0F04160)
TGBHG536_0C01650
KAFKAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
KNGKNAG_0G02190(KNAG0G02190) KNAG_0I01040(KNAG0I01040)
ZMKHG535_0G04170
PPAPAS_chr2-1_0628
DHADEHA2E20130g
PICPICST_61325(ERG27)
PGUPGUG_05066
SPAASPAPADRAFT_59939
LELLELG_00158
CALCAALFM_CR01140CA(ERG27)
CTPCTRG_00974
COTCORT_0A01630
CDUCD36_26140(ERG27)
CTENCANTEDRAFT_113050
YLIYALI0B17644g
CLUCLUG_05409
CLUSA9F13_23g00473
CAURCJI97_004310
SLBAWJ20_1569(ERG27)
PKZC5L36_0A05120
BNNFOA43_001771
BBRXBRETT_004734
OPAHPODL_01047
NCRNCU05991
NTENEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SMPSMAC_07919
PANPODANSg3046
TTTTHITE_164350
MTMMYCTH_69410
CTHRCTHT_0040790
PPEIPpBr36_00814
TMNUCRPA7_4666
SSCKSPSK_07425
FGRFGSG_13596
FPUFPSE_10479
FVRFVEG_04041
FOXFOXG_06186
NHENECHADRAFT_91272
TRETRIREDRAFT_2634
TRRM419DRAFT_72950
MAWMAC_02683
MAJMAA_02120
CMTCCM_05105
PLJVFPFJ_03970
VALVDBG_08048
VDAVDAG_01545
CFJCFIO01_12216
CLUPCLUP02_00244
CHIGCH63R_08186
SAPOSAPIO_CDS8162
ELAUCREL1_2995
PFYPFICI_14173
SSLSS1G_00326
BFUBCIN_03g05110
MBEMBM_01041
PSCOLY89DRAFT_608282
GLZGLAREA_07003
ANIAN5585.2
AFMAFUA_4G11500
ACTACLA_050580
NFINFIA_104700
AORAO090003001070
ANGANI_1_1880184(An04g05000)
AFVAFLA_000602
ALUCAKAW2_51484A(ERG27)
ACHEACHE_10583S(ERG27)
APUUAPUU_40944S(ERG27)
PCSPc22g06030
PDPPDIP_33960
TMFPMAA_041550
TRGTRUGW13939_02849
CIMCIMG_01575
CPWCPC735_048910
UREUREG_05299
PBLPAAG_02717
PBNPADG_01744
ABEARB_02354
TVETRV_04668
AJEHCAG_01553
BGHBDBG_07225
PNOSNOG_06194
PTEPTT_11743
BZECOCCADRAFT_22878
BSCCOCSADRAFT_32948
BORCOCMIDRAFT_4981
AALTCC77DRAFT_76456
ZTRMYCGRDRAFT_38293
PFJMYCFIDRAFT_82835
FFUCLAFUR5_04846 CLAFUR5_06261
NPAUCRNP2_3103
TMLGSTUM_00003619001
SPOSPBC1709.07(erg27)
CNECND03020
CNBCNBD3330
CNGCNAG_07437
CGICGB_D5570C
TMSTREMEDRAFT_43600
TASAA1Q1_03186
TVSTRAVEDRAFT_73290
DSQDICSQDRAFT_162108 DICSQDRAFT_88133
HIRHETIRDRAFT_312795
ADLAURDEDRAFT_80749
FMEFOMMEDRAFT_21336
GTRGLOTRDRAFT_103653
LBCLACBIDRAFT_303734
CCICC1G_09970
ABPAGABI1DRAFT79443(AGABI1DRAFT_79443)
ABVAGABI2DRAFT202140(AGABI2DRAFT_202140)
MRRMoror_13823
MOREE1B28_007285
SCMSCHCO_02624672(SCHCODRAFT_02624672)
CPUTCONPUDRAFT_103632
SLASERLADRAFT_333162
WSEWALSEDRAFT_70726
UMAUMAG_02895
PFPPFL1_04973
MGLMGL_2564
MRTMRET_0524
PGRPGTG_14396
MLRMELLADRAFT_64276
 » show all
Reference
1  [PMID:4387005]
  Authors
Swindell AC, Gaylor JL.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
  Journal
J Biol Chem 243:5546-55 (1968)
Reference
2  [PMID:6946726]
  Authors
Billheimer JT, Alcorn M, Gaylor JL.
  Title
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis.
  Journal
Arch Biochem Biophys 211:430-8 (1981)
DOI:10.1016/0003-9861(81)90474-4
Reference
3  [PMID:10535978]
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]
Reference
4  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.270
IUBMB Enzyme Nomenclature: 1.1.1.270
ExPASy - ENZYME nomenclature database: 1.1.1.270
BRENDA, the Enzyme Database: 1.1.1.270
CAS: 42616-29-5

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