KEGG   ENZYME: 1.1.1.289
Entry
EC 1.1.1.289                Enzyme                                 
Name
sorbose reductase;
Sou1p
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
D-glucitol + NADP+ = L-sorbose + NADPH + H+ [RN:R07346]
Reaction(KEGG)
R07346
Substrate
D-glucitol [CPD:C00794];
NADP+ [CPD:C00006]
Product
L-sorbose [CPD:C00247];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.
History
EC 1.1.1.289 created 2006
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K17742  sorbose reductase
K19633  sorbose reductase
Genes
QSU111983853 111994894 112002464 112032708 112033672
KLAKLLA0_E22397g KLLA0_E24003g
KMXKLMA_10715(SOU2) KLMA_10783(SOU1)
LTHKLTH0E13134g KLTH0F18062g KLTH0H14564g
ZROZYRO0A11902g ZYRO0G22440g
TDLTDEL_0B02360(TDEL0B02360) TDEL_0H00150(TDEL0H00150) TDEL_0H04540(TDEL0H04540)
TGBHG536_0F00190 HG536_0H02380
ZMKHG535_0F05860
PPAPAS_chr4_0754 PAS_chr4_0988
DHADEHA2A12386g DEHA2A14322g DEHA2A14344g DEHA2E08910g DEHA2F00990g
PICPICST_38255(SOU1)
PGUPGUG_05388 PGUG_05466
SPAASPAPADRAFT_148284 SPAPADRAFT_58963 SPAPADRAFT_60851 SPAPADRAFT_61649 SPAPADRAFT_62532
LELLELG_03159 LELG_05725 LELG_05727
CALCAALFM_C406380WA(SOU2) CAALFM_C406390WA(SOU1) CAALFM_CR07170WA(CaO19.732)
CTPCTRG_03131 CTRG_03800 CTRG_03801
COTCORT_0B01330 CORT_0D05940
CDUCD36_32760 CD36_45870(SOU2) CD36_45880(SOU1)
CTENCANTEDRAFT_103164 CANTEDRAFT_113000 CANTEDRAFT_113822 CANTEDRAFT_119297 CANTEDRAFT_119904
YLIYALI0B16192g YALI0D18964g
CLUCLUG_03390 CLUG_03744
CLUSA9F13_01g04004 A9F13_01g07997
CAURCJI97_001279 CJI97_002470 CJI97_003341
SLBAWJ20_3417(SPS19)
PKZC5L36_0A13160
BNNFOA43_003778
BBRXBRETT_004557
OPAHPODL_00133 HPODL_00159 HPODL_00206 HPODL_02372 HPODL_03552 HPODL_04542
SLUDSCDLUD_005287
NCRNCU03803 NCU09041
NTENEUTE1DRAFT115988(NEUTE1DRAFT_115988) NEUTE1DRAFT117650(NEUTE1DRAFT_117650)
SMPSMAC_02649 SMAC_05842
PANPODANSg2618 PODANSg9038
TTTTHITE_2108357
MTMMYCTH_2302150
CTHRCTHT_0067490
MGRMGG_07455
PPEIPpBr36_02364
TMNUCRPA7_3047 UCRPA7_6057 UCRPA7_7028 UCRPA7_8020
SSCKSPSK_07897
FGRFGSG_04248 FGSG_04826 FGSG_06104 FGSG_10025
FPUFPSE_04052(MTDH1) FPSE_04260 FPSE_04546 FPSE_08740
FVRFVEG_02746 FVEG_03510 FVEG_04737 FVEG_10438 FVEG_13843
FOXFOXG_05383 FOXG_05657 FOXG_07815 FOXG_11379 FOXG_13570
NHENECHADRAFT_105339 NECHADRAFT_42069 NECHADRAFT_63861 NECHADRAFT_69214 NECHADRAFT_81004 NECHADRAFT_85474
TRETRIREDRAFT_54086 TRIREDRAFT_60033 TRIREDRAFT_69840 TRIREDRAFT_74194(lxr1)
TRRM419DRAFT_121678 M419DRAFT_134365 M419DRAFT_34830 M419DRAFT_4602
MAWMAC_06617 MAC_08952
MAJMAA_01627 MAA_08417 MAA_09034
CMTCCM_07859 CCM_09007
PLJVFPFJ_06521 VFPFJ_08088 VFPFJ_11024
VALVDBG_02657
VDAVDAG_03582
CFJCFIO01_06096 CFIO01_06114 CFIO01_10017 CFIO01_13671
CLUPCLUP02_04226 CLUP02_11912
CHIGCH63R_03138 CH63R_04126 CH63R_11374
SAPOSAPIO_CDS7997
ELAUCREL1_4732 UCREL1_5183 UCREL1_7416
PFYPFICI_04519 PFICI_05413 PFICI_07972 PFICI_11801 PFICI_14636
SSLSS1G_01500 SS1G_08799
BFUBCIN_02g00470 BCIN_13g04760 BCIN_16g03380
MBEMBM_02748 MBM_04022
PSCOLY89DRAFT_595817 LY89DRAFT_656420 LY89DRAFT_781929
GLZGLAREA_05217 GLAREA_06523
ANIAN5547.2 AN7590.2 AN8113.2 AN8819.2
AFMAFUA_2G15430 AFUA_5G09400
ACTACLA_011160 ACLA_074390
NFINFIA_077930 NFIA_090670
AORAO090009000092 AO090012000287 AO090020000558 AO090103000206
ANGANI_1_2328074(An08g09340) ANI_1_438064(An07g03570) ANI_1_450094(An11g03260) ANI_1_736134(An15g05450)
AFVAFLA_002003 AFLA_004926 AFLA_010099 AFLA_011270 AFLA_013316
ALUCAKAW2_11826S(LXR3) AKAW2_60217S(LXR1) AKAW2_80300S
ACHEACHE_10087S ACHE_11906S ACHE_31392S ACHE_50422S ACHE_50429A(LXR1_1) ACHE_50556S(LXR1_2) ACHE_50662S ACHE_50760S
APUUAPUU_12355S(SOU1) APUU_20144S APUU_40897A APUU_60913A APUU_80356S(LXR1)
PCSPc12g00830 Pc16g10970 Pc16g13310 Pc21g18520 Pc22g01350
PDPPDIP_04500 PDIP_45660 PDIP_50980 PDIP_65860
TMFPMAA_079570 PMAA_088300
TRGTRUGW13939_00052 TRUGW13939_01338 TRUGW13939_01729 TRUGW13939_09267 TRUGW13939_10687
CIMCIMG_06663
CPWCPC735_031160
UREUREG_03776
PBLPAAG_04181
PBNPADG_07435
ABEARB_02722
TVETRV_00610
AJEHCAG_00626
BGHBDBG_01254
PNOSNOG_01607 SNOG_15488(AY788902)
PTEPTT_06742 PTT_07726
BZECOCCADRAFT_32637 COCCADRAFT_36831
BSCCOCSADRAFT_32603 COCSADRAFT_34195
BORCOCMIDRAFT_93520 COCMIDRAFT_97193
AALTCC77DRAFT_1054735 CC77DRAFT_1091062 CC77DRAFT_931278
ZTRMYCGRDRAFT_64923 MYCGRDRAFT_74599 MYCGRDRAFT_84831
PFJMYCFIDRAFT_211363 MYCFIDRAFT_38554 MYCFIDRAFT_71664
FFUCLAFUR5_04588 CLAFUR5_07014 CLAFUR5_09329
BCOMBAUCODRAFT_29448 BAUCODRAFT_64133 BAUCODRAFT_74440
NPAUCRNP2_3500
TMLGSTUM_00000686001
SPOSPAC22A12.17c SPAC8E11.10 SPCC1739.08c
CNECNL05930
CNBCNBI0900
CNGCNAG_05024
CGICGB_D1070C
TASAA1Q1_05496
PSQPUNSTDRAFT_83219
FMEFOMMEDRAFT_123887
GTRGLOTRDRAFT_108403 GLOTRDRAFT_133516
LBCLACBIDRAFT_256071
CCICC1G_15600
ABPAGABI1DRAFT114569(AGABI1DRAFT_114569)
ABVAGABI2DRAFT194752(AGABI2DRAFT_194752)
CPUTCONPUDRAFT_138022
SLASERLADRAFT_436806
WSEWALSEDRAFT_31566 WALSEDRAFT_63204
WICJ056_002472 J056_004249
UMAUMAG_05252 UMAG_10938
PFPPFL1_02969 PFL1_04231 PFL1_04817
MGLMGL_3023
MRTMRET_3631
MSYMMSY001_1257
PGRPGTG_01366
MLRMELLADRAFT_55312
LIZLGH83_17090
GOXGOX1432
GOHB932_1684
GOYGLS_c15490
GALA0U94_10565
GTIFXF46_02985
GSPIGS75_08345
GFAMKW11_02970
GDIGDI0886(mtlK)
GDJGdia_1133
GXYGLX_20590
GXLH845_2922
KNAB0W47_08225
KEUS101446_02540
KSCCD178_00846(por_1)
KREGWK63_01240
AACEA0U92_16660
ABGAsbog_02764
KBAA0U89_13385
NCHA0U93_13575
NTND5366_09545
SSAME3D00_06230
EBLAJGUZn3_11270(por)
KHAIFJ82_15285
PARZDTQ13_03645
 » show all
Reference
1  [PMID:16134116]
  Authors
Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E
  Title
Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:957-69 (2005)
DOI:10.1002/yea.1282
  Sequence
Reference
2
  Authors
Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E.
  Title
Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:1171 (2005)
Reference
3
  Authors
Sugisawa, T., Hoshino, T. and Fujiwara, A.
  Title
Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1.
  Journal
Agric Biol Chem 55:2043-2049 (1991)
Reference
4  [PMID:11790761]
  Authors
Shinjoh M, Tazoe M, Hoshino T
  Title
NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.
  Journal
J Bacteriol 184:861-3 (2002)
DOI:10.1128/JB.184.3.861-863.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.289
IUBMB Enzyme Nomenclature: 1.1.1.289
ExPASy - ENZYME nomenclature database: 1.1.1.289
BRENDA, the Enzyme Database: 1.1.1.289
CAS: 138440-90-1

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