KEGG   ENZYME: 1.1.1.312
Entry
EC 1.1.1.312                Enzyme                                 
Name
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase;
2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase;
4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase;
alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase;
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase;
LigC;
ProD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase
Reaction(IUBMB)
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+ [RN:R04279]
Reaction(KEGG)
R04279;
(other) R04278 R04418 R04419
Substrate
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal;
NADP+ [CPD:C00006]
Product
2-oxo-2H-pyran-4,6-dicarboxylate;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate [1]. However, later studies showed that the substrate is the hemiacetal form [3], and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4].
History
EC 1.1.1.312 created 1978 as EC 1.2.1.45, transferred 2011 to EC 1.1.1.312
Pathway
ec00350  Tyrosine metabolism
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10219  2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
Genes
VNAPN96_18475
VEJVEJY3_18041
VFLAL536_10275
VZIG5S32_20230
EMODM558_04780
PATPatl_3884
PCARPC2016_2099
AAWAVL56_08855
ALRDS731_01475
CSACsal_0286
MMWMmwyl1_3923
MMEMarme_0839
MPCMar181_0387
MPRIMP3633_0458
MARDIBG28_02995
MFOIJSY38_12280
MPRFJ8N69_06100
MRHIKDW99_17810
MGEOCFI10_14905
MARLHH196_02890
AJPAMJAP_1190(ligC)
GSNYC6258_04095
RFOREIFOR_00532
NAQD0T90_09300
NBLGJV52_09120
VFFVITFI_CDS3225
VITADP71_27580
VSTLVJ81_00705
VMSLVJ82_10320
AMAHDLM_2154
AQSDKK66_18660
BPHBphy_3203
BPXBUPH_02686
HYFDTO96_100894(ligC)
BOJCBF45_13145
PUDG9Q38_00580
CDNBN940_08561
AFQAFA_05510
AAQUD3M96_07050
OUEI6G29_08395
PIGEGT29_11670
KGYEHF36_13165
RFRRfer_0329
RSBRS694_12670
RHYRD110_16975
RHFEUB48_12920
RHOAHZ993_17880
PNAPnap_2026
PVACHC248_00685(ligC)
ACKC380_22695
ACRABSY15_1203
ACIDCBP33_05255
ACIPCBP36_05705 CBP36_20295
ACINCBP34_05090
ACISCBP35_20370
ACIOEAG14_01265
AMONH9L24_06075
AANTHUK68_10970
ARADKI609_21435
VEIVeis_0171
DACDaci_4444
DELDelCs14_1674 DelCs14_2360
DTSBI380_01400
DHKBO996_20095
DLAI6G47_02140
CTTCtCNB1_2740
CTESO987_16255
CKEB5M06_09350
COFFOZ74_08495
CODOLAD35_20145
RTARta_24750
OTKC6570_16445
LIML103DPR2_01499(ligC)
LIHL63ED372_01146(ligC)
HYRBSY239_2221
HYBQ5W_10735
HYLLPB072_16060
HYCE5678_08750
HPSEHPF_08090(ligC)
HYNF9K07_12210
HTNKI616_18165
HCZG9Q37_09985
DIHG7047_27845
CBAASRAA_1349
CBABSMCB_0796
MIUABE85_08005
SNNEWH46_19150
LCHLcho_3638
SHDSUTH_01243
ABREpbN1_38880
AZOazo2536(ligC)
AOAdqs_2693
AZRCJ010_16055
THUAC731_016815
TCLTchl_1063
TAKTharo_1104
DDZDSYM_13570
AVPAVENP_2163(ligC)
MLNA9174_33730
ORMHTY61_00110
NEOCYG48_12400
BRABRADO2343(ligC)
BBTBBta_2703(ligC)
AOLS58_52560
BROBRAD285_4994(ligC)
BSEIKMZ68_25425
RPARPA4703(ligC)
RPBRPB_0871
RPDRPD_0981
RPERPE_0752
RPTRpal_5184
RPXRpdx1_4878
RHZRHPLAN_69850
BSBBresu_2113
BGOEIFJ75_11170
MALGMALG_02288
OCDFHY55_07575
TGLHFZ77_17810
SEDIEBB79_03565
NARSaro_2811
NPPPP1Y_Mpl10457
NPNJI59_20905
NOVTQ38_025015 TQ38_028420
NOTC7W88_02260
NORFA702_07545
NDRHT578_08925 HT578_09615
SMAZLH19_17685
RDICMV14_06895
SPHITS85_18525
SSANNX02_17495
SPANAWL63_08160
SKRBRX40_12180
SPHCCVN68_17235
SPIIG7077_01505
SSUAFPZ54_06140
SBINSBA_ch2_7430
SGLCM1K48_07910
SCHSphch_3900
SSYSLG_12490(ligC)
SPHBEP837_03495(ligC)
SPHRBSY17_3445
SHYDCJD35_16830 CJD35_19590
SYAA6768_17470
SPYGYGS_C2P1458
SAMISAMIE_1030380
SPHGAZE99_04510
SFLASPHFLASMR4Y_02989(ligC)
SPHYCHN51_00885
BLASBSY18_3525
BFWB5J99_08420
SPHSETR14_07920
POQKZX46_07325
PMEAKTC28_03835
ALBAEB_P0241
AAYWYH_01910(ligC)
ADOA6F68_01078(ligC)
CMANA9D14_17250
ABSAZOBR_p310194(ligC)
ABQABAZ39_27990
AZTTSH58p_32540
NCBC0V82_22505
SKTIGS68_10715
SMUCJL100_016145
SROEJL101_014930
MAGamb0255
MAGXXM1_1092(ligC)
MAGNWV31_13620
MAGQMGMAQ_2671(ligC)
APBSAR116_0937
SNEANBZ79_04500
CCYCSCMU_02420(pcmB)
SLAUSLA_7099
SHUNDWB77_01946(ligC_2)
KSKKSE_75130(pcmB)
KITCFP65_0439
MAURBOH66_06350
MHOSCXR34_05675
MOOBWL13_00077(ligC_1)
MSFIT882_15435
AMINAUMI_19370
AUMAURMO_01267
AUWAURUGA1_00421(ligC)
ARTArth_4372
ARTPE5206_14140
APNAsphe3_42390
PEIH9L10_00570
JTLM6D93_14070
DPDDeipe_1701
 » show all
Reference
1  [PMID:26671]
  Authors
Maruyama K, Ariga N, Tsuda M, Deguchi K.
  Title
Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase.
  Journal
J Biochem (Tokyo) 83:1125-34 (1978)
DOI:10.1093/oxfordjournals.jbchem.a132002
Reference
2  [PMID:528534]
  Authors
Maruyama K
  Title
Isolation and identification of the reaction product of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase.
  Journal
J Biochem 86:1671-7 (1979)
DOI:10.1093/oxfordjournals.jbchem.a132687
Reference
3  [PMID:6841353]
  Authors
Maruyama K.
  Title
Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
  Journal
J Biochem (Tokyo) 93:557-65 (1983)
DOI:10.1093/oxfordjournals.jbchem.a134210
Reference
4  [PMID:11073908]
  Authors
Masai E, Momose K, Hara H, Nishikawa S, Katayama Y, Fukuda M
  Title
Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 182:6651-8 (2000)
DOI:10.1128/JB.182.23.6651-6658.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.312
IUBMB Enzyme Nomenclature: 1.1.1.312
ExPASy - ENZYME nomenclature database: 1.1.1.312
BRENDA, the Enzyme Database: 1.1.1.312

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