1-deoxy-11beta-hydroxypentalenic acid dehydrogenase;
ptlF (gene name);
penF (gene name)
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+ [RN:
Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
EC 18.104.22.1680 created 2012
ec00998 Biosynthesis of various antibiotics
ec01110 Biosynthesis of secondary metabolites
K17747 1-deoxy-11beta-hydroxypentalenate dehydrogenase
SLE: sle_13200(sle_13200) Taxonomy
You Z, Omura S, Ikeda H, Cane DE
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate.
ExPASy - ENZYME nomenclature database: 22.214.171.1240