KEGG   ENZYME: 1.1.1.349
Entry
EC 1.1.1.349                Enzyme                                 
Name
norsolorinic acid ketoreductase;
aflD (gene name);
nor-1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(1'S)-averantin:NADP+ oxidoreductase
Reaction(IUBMB)
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ [RN:R10309]
Reaction(KEGG)
R10309
Substrate
(1'S)-averantin [CPD:C20499];
NADP+ [CPD:C00006]
Product
norsolorinic acid [CPD:C20452];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.1.1.349 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17644  norsolorinic acid ketoreductase
Genes
QSU111983631
PANPODANSg8566
PPEIPpBr36_02616
TMNUCRPA7_6053
NHENECHADRAFT_19049 NECHADRAFT_44851
TRETRIREDRAFT_105884
TRRM419DRAFT_7213
VALVDBG_02925 VDBG_06335
VDAVDAG_03485
CFJCFIO01_09694 CFIO01_11244
CHIGCH63R_01668 CH63R_08584
ELAUCREL1_771 UCREL1_8646
PFYPFICI_02604 PFICI_13483
BFUBCIN_09g00680
PSCOLY89DRAFT_589972
GLZGLAREA_06058 GLAREA_09658
ANIAN7821.2
AFMAFUA_5G14120
NFINFIA_072850
AORAO090023000875 AO090026000011 AO090038000063
ANGANI_1_1648104(An12g03210) ANI_1_1984104(An12g06400) ANI_1_2226024(An02g01090)
AFVAFLA_006309 AFLA_007227 AFLA_012318
ALUCAKAW2_80215A
ACHEACHE_50053S
APUUAPUU_12296S APUU_20041S APUU_61047A
PCSPc12g16460
PDPPDIP_02390
AALTCC77DRAFT_1088875 CC77DRAFT_546209
FFUCLAFUR5_14299
NPAUCRNP2_9593
 » show all
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl Environ Microbiol 59:2486-92 (1993)
DOI:10.1128/AEM.59.8.2486-2492.1993
Reference
2  [PMID:10584035]
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
DOI:10.1128/AEM.65.12.5639-5641.1999
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.349
IUBMB Enzyme Nomenclature: 1.1.1.349
ExPASy - ENZYME nomenclature database: 1.1.1.349
BRENDA, the Enzyme Database: 1.1.1.349

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