KEGG   ENZYME: 1.1.1.349
Entry
EC 1.1.1.349                Enzyme                                 

Name
norsolorinic acid ketoreductase;
aflD (gene name);
nor-1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(1'S)-averantin:NADP+ oxidoreductase
Reaction(IUBMB)
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ [RN:R10309]
Reaction(KEGG)
R10309
Substrate
(1'S)-averantin [CPD:C20499];
NADP+ [CPD:C00006]
Product
norsolorinic acid [CPD:C20452];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.1.1.349 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17644  norsolorinic acid ketoreductase
Genes
QSU: 111983631
PAN: PODANSg8566
TMN: UCRPA7_6053
NHE: NECHADRAFT_19049 NECHADRAFT_44851
TRE: TRIREDRAFT_105884
TRR: M419DRAFT_7213
VAL: VDBG_02925 VDBG_06335
VDA: VDAG_03485
CFJ: CFIO01_09694 CFIO01_11244
ELA: UCREL1_771 UCREL1_8646
ANI: AN7821.2
ANG: ANI_1_1648104(An12g03210) ANI_1_1984104(An12g06400) ANI_1_2226024(An02g01090)
 » show all
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl Environ Microbiol 59:2486-92 (1993)
DOI:10.1128/AEM.59.8.2486-2492.1993
Reference
2  [PMID:10584035]
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
DOI:10.1128/AEM.65.12.5639-5641.1999
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.349
IUBMB Enzyme Nomenclature: 1.1.1.349
ExPASy - ENZYME nomenclature database: 1.1.1.349
BRENDA, the Enzyme Database: 1.1.1.349

DBGET integrated database retrieval system