KEGG   ENZYME: 1.1.1.43
Entry
EC 1.1.1.43                 Enzyme                                 
Name
phosphogluconate 2-dehydrogenase;
6-phosphogluconic dehydrogenase;
phosphogluconate dehydrogenase;
gluconate 6-phosphate dehydrogenase;
6-phosphogluconate dehydrogenase (NAD+);
2-keto-6-phosphogluconate reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
6-phospho-D-gluconate + NAD(P)+ = 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+ [RN:R02032 R02034]
Reaction(KEGG)
R02032 R02034
Substrate
6-phospho-D-gluconate [CPD:C00345];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
6-phospho-2-dehydro-D-gluconate [CPD:C01218];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.43 created 1961
Pathway
ec00030  Pentose phosphate pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00032  phosphogluconate 2-dehydrogenase
Genes
PAEPA2263
PAEVN297_2336
PAEIN296_2336
PAUPA14_35320(kguD)
PAPPSPA7_2977
PAGPLES_30411
PAFPAM18_2777
PNCNCGM2_3273(kguD)
PAEBNCGM1900_4267(kguD)
PDKPADK2_13960
PSGG655_13725
PRPM062_11835
PAEPPA1S_14305
PAERPA1R_gp0064
PAEMU769_13890
PAELT223_15535
PAESSCV20265_3062
PAEUBN889_02470
PAEGAI22_19550
PAECM802_2333
PAEOM801_2335
PCQPcP3B5_34720(ghrB_4)
PPUPP_3376(ptxD)
PPFPput_2382
PPGPputGB1_2568
PPWPputW619_2000 PputW619_2571
PPTPPS_2854
PPBPPUBIRD1_2404
PPIYSA_11138
PPXT1E_5148(tkrA)
PPUHB479_14190
PPUTL483_13870
PPUNPP4_27660(kguD)
PPUDDW66_3112
PMONX969_13660
PMOTX970_13305
PMOSO165_011465
PPJRK21_01808
PORAPT59_06300
PMOLCLJ08_00430
PFLPFL_2717(ghrB1)
PPRCPFLCHA0_c27780(ghrB2)
PPROPPC_2764(ghrB1)
PFEPSF113_3674(kguD)
PFNHZ99_04035
PFOPfl01_2904(yiaE)
PFSPFLU_2712
PFCPflA506_2981(ghrB1)
PPZH045_10165
PFBVO64_0047
PMANOU5_0566
PTVAA957_01705
PVRPverR02_13675
PAZOAYR47_20865
POIBOP93_11135
PRXHRH33_12390
PFWPF1751_v1c23760(ghrB)
PFFPFLUOLIPICF724840
PFXA7318_10960
PSTTCH92_21465
PLULFOB45_19910
PBAPSEBR_a3251
PBCCD58_12930
PPUUPputUW4_02430
PSKU771_18235
PCHEY04_16640
PCZPCL1606_27210
PCPJM49_14100
PFZAV641_12810
PLQAA042_20165
PPVNJ69_11480
PSEMTO66_17295
PSECCCOS191_2350(ghrB2)
PPSYAOC04_09425
PSOSPOS17_3330(ghrB1)
PKRAYO71_17590
PFKPFAS1_25365
PANRA7J50_2583
PPSLBJP27_21050
PSILPMA3_15845
PYMAK972_2491
PKEDLD99_15200
PUMHGP31_16590
PGGFX982_03690
PPSHG5J76_15890
PGYAWU82_13105
PEZHWQ56_12570
PBZGN234_05380
PATAJWU58_12640
PZEHU754_013585
PMOEHV782_014295
PSEPC4K39_5321
PVWHU752_013905
PTRTHU722_0013400
PSAMHU731_003205
PTZHU718_014240
PSHHHU773_014555
PXNHU772_014480
PHVHU739_003595
PPRGHU725_011080
PANHHU763_012730
PASGKSS96_16120
PMUYKSS95_13995
PMAMKSS90_11505
PAZEKSS91_13355
PALVKSS97_12555
PIEHU724_015850
PTAENCTC10697_02010(ghrB) NCTC10697_02408(ghrB2)
PGFJ0G10_16905
AVNAvin_26910(kguD)
AVLAvCA_26910(kguD)
AVDAvCA6_26910(kguD)
ACXAchr_21860(kguD)
CSACsal_0273
HELHELO_1170(ghrB)
HCSFF32_18040
HAKKO116_02812
HAMHALO3070
HHUAR456_01360 AR456_06690
HCOLOKO_02347(ghrB)
HALOBWR19_17920
HHHCLM76_17505
HAFC8233_00385
HVNEI420_12570
HOLHORIV_24120
HSRHSBAA_22590
HTTHZS52_17665 HZS52_19875
HCAMI4484_01920
HSXHNO51_01825
HSVHNO53_01735
HTXEKK97_02335
HAAA5892_14845
CMAIBFX80_06870
CAMHLCW13_10365
RPJN234_30545
REHH16_B1813(kguD)
CNCCNE_2c17540(kguD)
CUHBJN34_28480
CBWRR42_m1906
COXE0W60_19810
PHSC2L64_42750
PTERC2L65_39915
BUOBRPE64_ECDS01190
PUTPT7_0392
PUSCKA81_08250
CDNBN940_05166
PACRFXN63_07470
PARKLSG25_09315
POLBpro_1736
PNAPnap_1485
ACKC380_16165
ARADKI609_15330
VAPVapar_3413
VPEVarpa_2201
VPDVAPA_1c35200
VAAAX767_01995
VAMC4F17_00970
CODOLAD35_00445
RTARta_05240(tkrA)
HYLLPB072_01360
HYCE5678_20160
MELMC7H73_07370
KIAG8A07_09020
XYKGT347_16870
ATERMW290_07725
SECHB18_23390
SVCSTVA_44280
PARHI5S86_13805
CGOTJ1899_12015
 » show all
Reference
1  [PMID:13894458]
  Authors
FRAMPTON EW, WOOD WA.
  Title
Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate.
  Journal
J Biol Chem 236:2571-7 (1961)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.43
IUBMB Enzyme Nomenclature: 1.1.1.43
ExPASy - ENZYME nomenclature database: 1.1.1.43
BRENDA, the Enzyme Database: 1.1.1.43
CAS: 9001-82-5

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