KEGG   ENZYME: 1.1.1.430
Entry
EC 1.1.1.430                Enzyme                                 
Name
D-xylose reductase (NADH);
XYL1 (gene name) (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
xylitol:NAD+ oxidoreductase
Reaction(IUBMB)
xylitol + NAD+ = D-xylose + NADH + H+ [RN:R09477]
Reaction(KEGG)
R09477
Substrate
xylitol [CPD:C00379];
NAD+ [CPD:C00003]
Product
D-xylose [CPD:C00181];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH (cf. EC 1.1.1.431, D-xylose reductase (NADPH)). Some D-xylose reductases have dual coenzyme specificity, though they still prefer NADPH to NADH (cf. EC 1.1.1.307, D-xylose reductase [NAD(P)H]). The enzyme from Candida parapsilosis is a rare example of a xylose reductase that significantly prefers NADH, with Km and Vmax values for NADH being 10-fold lower and 10-fold higher, respectively, than for NADPH.
History
EC 1.1.1.430 created 2022
Orthology
K17743  D-xylose reductase
Genes
SASA100196319(xyl1)
QSU112005872 112027707
SCEYHR104W(GRE3)
SEUBDI49_2509
SPAOSPAR_H01460
AGOAGOS_ACL107C
ERCEcym_5508
KLAKLLA0_E21627g
KMXKLMA_10683(XYL1)
LTHKLTH0F16610g
ZROZYRO0A06336g
CGRCAGL0I01122g
NCSNCAS_0A06660(NCAS0A06660)
NDINDAI_0D01600(NDAI0D01600)
TPFTPHA_0E01860(TPHA0E01860)
TBLTBLA_0A00630(TBLA0A00630) TBLA_0F01720(TBLA0F01720)
TDLTDEL_0E02150(TDEL0E02150)
TGBHG536_0E00720
KAFKAFR_0C05320(KAFR0C05320)
KNGKNAG_0B03780(KNAG0B03780)
ZMKHG535_0C03920
PPAPAS_chr3_0744
DHADEHA2B00572g DEHA2F13068g
PICPICST_89614(XYL1)
PGUPGUG_00922 PGUG_02290
SPAASPAPADRAFT_61339(XYL1.2) SPAPADRAFT_61341(XYL1.1)
CALCAALFM_C502930CA(GRE3)
CTPCTRG_05978 CTRG_05993
COTCORT_0F01440
CDUCD36_52690(XYRA)
CTENCANTEDRAFT_95032
YLIYALI0D07634g
CLUCLUG_01135
CLUSA9F13_09g01958
CAURCJI97_000813
SLBAWJ20_3140(GRE3)
PKZC5L36_0B11990
BNNFOA43_003071(XYL1)
BBRXBRETT_005324(XYL1)
OPAHPODL_01370
SLUDSCDLUD_000181
NCRNCU08384(xr)
NTENEUTE1DRAFT133088(NEUTE1DRAFT_133088)
SMPSMAC_04649
PANPODANSg09635
TTTTHITE_2121064
MTMMYCTH_43671
CTHRCTHT_0056950
MGRMGG_01404 MGG_03648
PPEIPpBr36_00917 PpBr36_05674
TMNUCRPA7_3687 UCRPA7_6874
SSCKSPSK_06315
FGRFGSG_01523
FPUFPSE_05024
FVRFVEG_08194 FVEG_09602
FOXFOXG_01819 FOXG_11189
NHENECHADRAFT_102983 NECHADRAFT_38020
TRETRIREDRAFT_107776(xyl1)
TRRM419DRAFT_94809
MAJMAA_00542
PLJVFPFJ_08966
VALVDBG_00802 VDBG_03846 VDBG_06547
VDAVDAG_00411 VDAG_01073 VDAG_05087
CFJCFIO01_01300 CFIO01_01602
CHIGCH63R_03776 CH63R_05876
SAPOSAPIO_CDS7670 SAPIO_CDS9478
ELAUCREL1_14 UCREL1_6453
PFYPFICI_01687 PFICI_04525 PFICI_07157
SSLSS1G_05911
BFUBCIN_05g01550
MBEMBM_04242 MBM_09727
PSCOLY89DRAFT_599386 LY89DRAFT_657917
GLZGLAREA_03723
ANIAN0423.2
AFMAFUA_1G04820
ACTACLA_029850
NFINFIA_019940
AORAO090003000859
ANGANI_1_2444014(An01g03740)
AFVAFLA_000817
ALUCAKAW2_20539A(XYL1)
APUUAPUU_11638A(XYL1)
PCSPc16g09600
PDPPDIP_20350
TMFPMAA_054010 PMAA_100740
TRGTRUGW13939_00477
CIMCIMG_04915
CPWCPC735_069630
UREUREG_06636
ABEARB_06141
TVETRV_03808
PNOSNOG_12824
PTEPTT_08729
BZECOCCADRAFT_7101
BSCCOCSADRAFT_90781
BORCOCMIDRAFT_103379
AALTCC77DRAFT_925768
ZTRMYCGRDRAFT_56833
PFJMYCFIDRAFT_187110
FFUCLAFUR5_06085 CLAFUR5_06716
BCOMBAUCODRAFT_374705
NPAUCRNP2_5917
TMLGSTUM_00005097001
TVSTRAVEDRAFT_161569 TRAVEDRAFT_68124
DSQDICSQDRAFT_152560 DICSQDRAFT_95722
PCOPHACADRAFT_266555 PHACADRAFT_82194
SHSSTEHIDRAFT_117277 STEHIDRAFT_124813
HIRHETIRDRAFT_59016
PSQPUNSTDRAFT_95399
ADLAURDEDRAFT_181771
FMEFOMMEDRAFT_145959
GTRGLOTRDRAFT_113068 GLOTRDRAFT_71965
MPRMPER_01564
MRRMoror_16424
MOREE1B28_001457
CCICC1G_12853
SCMSCHCO_02610865(SCHCODRAFT_02610865)
PCUBJR316_0009805
CPUTCONPUDRAFT_96186
SLASERLADRAFT_455569
 » show all
Reference
1  [PMID:14532079]
  Authors
Lee JK, Koo BS, Kim SY
  Title
Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis.
  Journal
Appl Environ Microbiol 69:6179-88 (2003)
DOI:10.1128/AEM.69.10.6179-6188.2003
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.430
IUBMB Enzyme Nomenclature: 1.1.1.430
ExPASy - ENZYME nomenclature database: 1.1.1.430
BRENDA, the Enzyme Database: 1.1.1.430

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