3alpha-hydroxysteroid 3-dehydrogenase (Si-specific);
3alpha-hydroxysteroid dehydrogenase (B-specific);
3alpha-hydroxysteroid 3-dehydrogenase (B-specific);
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific)
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Si-specific)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:
The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC
, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific).
EC 220.127.116.11 created 1961, modified 1986, modified 1990, modified 2012, modified 2013
ec00120 Primary bile acid biosynthesis
ec00140 Steroid hormone biosynthesis
K00037 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
MCC: 722483 722490(AKR1C4)
MCF: 102116844 102117205(AKR1C4)
CATY: 105597444 105597447
CJC: 100405255 100405615(AKR1C4) » show all
JARABAK J, TALALAY P.
Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases.
J Biol Chem 235:2147-51 (1960)
KOCHAKIAN CD, CARROLL BR, UHRI B.
Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates.
J Biol Chem 224:811-8 (1957)
MARCUS PI, TALALAY P.
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
J Biol Chem 218:661-74 (1956)
Penning TM, Sharp RB
Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.
ExplorEnz - The Enzyme Database: 18.104.22.168
ExPASy - ENZYME nomenclature database: 22.214.171.124