KEGG   ENZYME: 1.1.1.51
Entry
EC 1.1.1.51                 Enzyme                                 
Name
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
History
EC 1.1.1.51 created 1961
Pathway
ec00140  Steroid hormone biosynthesis
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04119  aldo-keto reductase family 1 member C3
K05296  3(or 17)beta-hydroxysteroid dehydrogenase
Genes
HSA8644(AKR1C3)
PTR100612718(AKR1C3) 100612887 746545
PPS100986388 100987632 100988315
GGO101144878 101147265 101152195
PON100174617(AKR1C3) 100432652 100461633 100462259
NLE100593325 100604844 100606512
MCC100430336 722485 722496
MCF102116465 102142023(HSD17B5) 102143072 102144231
CSAB103237812 103237813 103237816
CATY105587690 105597446 105597481
PANU100997485 101022585 101024707
TGE112631307 112631750
RRO104674747
RBB108521036 108532990
TFN117082052 117082118 117083437
PTEH111528130 111528985 113224919
CJC100406962 100409025 100409384
SBQ101041594 101042225 101049957
CSYR103261879 103261880 103261882 103261883 103263298 103263300
MMUR105858219 105858220 105858221 105858224
OGA100942491 100967071
MCAL110308148
MPAH110321514 110333839 110333848
RNO361267(Akr1c15)
MCOC116081731
MUN110560700
CGE100768090 100768376
PLEU114708096
NGI103725884 103725890 103725892 103746652
HGL101702106
CPOC100727454
CCAN109678869 109680334 109680990
DSP122113031
NCAR124961142 124961655
OPI101524567 101525842 101526664 101526901 101527313 101527569 101527977
TUP102478063 102478495 102491222 102491650
CFA497070(AKR1C3)
VVP112933725
VLG121496638
AML100483758
UMR103676234
UAH113241124
UAR123802294(AKR1C8)
ELK111158636
LLV125107753
MPUF101678776
ORO101377633 101379669
EJU114217720
ZCA113921662
MLX118021623 118021905
FCA100510801(AKR1C3)
PYU121014878
PBG122473163
PTG102963188
PPAD109273789
AJU106988139
HHV120237198
BTA100139386(20ALPHA-HSD) 112441538 112449293 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
BOM102267155 102269337 102271037 102271453 102271733 102272308 102272594 102272882 102273443 102283454 102284205
BIU109567627 109567629 109568074 109568076 109568077 109568079 109568080 109568087
BBUB102389138 102395293 102395635 102396460 102396772 102398476 102399119 102400645 102404780 102416534
CHX102176340 102176622 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498
OAS101106610 101107119 101107541 101107809 101109111 101109377 101109633 101110434 101110693 105614315 106990122 114108656 443108(PGFS)
ODA120860627 120868601 120869467 120869469 120869471
CCAD122447956 122447958 122447959 122448269 122448454 122448455 122448456 122448511 122448512
SSC654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)
CFR102511678 116656624 116661570
CBAI105074137 105074417 105074427 105074728
CDK105104488 105104489 105105880
VPC102531609 102541232 102541486
BACU103002145 103003050
LVE103069218
OOR101273575 101281536
DLE111170128 111170129
PCAD102978533
PSIU116748968 116749098
ECB100057212 100070491 100070501 100070509 100070616 111771771 111771772
EPZ103541472 103541473 103542048
EAI106824650 106827241 106827468 106846832 106846833 106846834 123281999
MYB102254990 102255491
MYD102751586 102763642
MMYO118672630 118672665
MLF102421358 102428982
MNA107542430 107542432
PKL118702292 118702295
HAI109378613
DRO112321159 112323007
SHON118977133
AJM119057712
PDIC114492418
PHAS123824859 123831227(AKR1C8)
MMF118632067 118632135
PALE102889546
PGIG120608988
PVP105299187
MJV108383288 108384939 108393830 108407235 108407237 108407238
TOD119244650 119245260
SARA101543981 101545704 101551007 101551999 101555320 101555749
LAV100659630 100659914
TMU101342771 101360332
DNM101428157 101433437
OAA100085065 100085965 100085983
PSS102446010 102446253 102446483
CMY102946053
CPIC101940001 101940260 101940524
TST117882842
CABI116815619
MRV120395343 120395494 120395542
PVT110070400 110071420 110088827
PMUA114590236 114604979 114604980 114604981 114605230 114605592
ZVI118090693 118090694 118090915
GJA107108026
XLA100049750(XB5895996.L) 443571(akr1c3.L)
XTR100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 734139 779627(akr1c3)
NPR108789947 108789949 108799287 108799288 108799289 108799290 108799291
RTEM120921832 120932840
PPYR116168970
DMK116918341
PMAX117329343 117329344 117331065
MMER123536211
RGLCS053_01735
PREPCA10_43660
PFUWKF707C_11730 KF707C_11870
PPUUPputUW4_01679
PKCPKB_4320
PFZAV641_10575
PPSYAOC04_07875
PSETTHL1_4408
PSILPMA3_11580
PKEDLD99_14670
PUMHGP31_20975
PPSHG5J76_13530
PLALFXN65_05815 FXN65_21130
PAZEKSS91_19200
PPHABVH74_17925
PTAENCTC10697_02065
PCAVD3880_17455
PALIA3K91_2273
PSYPE5677_02060
SPLSpea_2173
SHLShal_2144
CBERB5D82_11215
PRRAT705_22580
PVBJ5X90_19405
PSYMJ1N51_11265
SNANI6N98_05660
ZALAZF00_07095
OSGBST96_18245
MAGAMag101_11180 Mag101_17580
HJABST95_16580
HALCEY643_05560
KIMG3T16_08455
AFUSEYZ66_13070
ASIPAQUSIP_13610(cpnA_2)
LCJNCTC11976_00397(phaB_1)
FCFFNFX1_1204
FPHFphi_0049
FPTBZ13_56
FPIBF30_220
FPMLA56_250
FPXKU46_1333
FPZLA55_1285
FPJLA02_1545
FRTF7308_1194
FRFLO80_02190
FRXF7310_06325
FADCDH04_04000
FMIF0R74_04375
FNNFSC774_04745
FSRKQR59_05790
OAIOLEAN_C32440
MSECLN244_04840
BSANCHH28_02370
NIKF5I99_08975
SDFACG33_10715 ACG33_10795
SOKD0B54_05265
SINIGT972_08470
FCEJN531_005460
RPJN234_25135
RINACS15_4335 ACS15_4391
REHH16_B0642(h16_B0642) H16_B0649(h16_B0649)
CNCCNE_2c05880 CNE_2c05960 CNE_BB1p04020
CUHBJN34_26905 BJN34_30930
REUReut_A1545 Reut_A1552
CTIRALTA_B0491
CBWRR42_s2341
COXE0W60_08155 E0W60_08190
BURBcep18194_B1514
BCTGEM_4149
BCEPAPZ15_31395
BPYRABD05_28030
BCONNL30_04370
BDFWI26_20980
BTEIWS51_05535
BSTLBBJ41_21110
BANNJFN94_25445
BURKDM992_32810
BFNOI25_4612
PVEUC34_06900
CABASBC2_48780
CTTCtCNB1_1764
CTESO987_11065
DIHG7047_09040 G7047_10950
MPTMpe_A0884
METPC1M51_13620
DOEDENOEST_3109 DENOEST_3547(cpnA)
AZIAzCIB_1461
AZDCDA09_09700
THUAC731_008840
THKCCZ27_19355
GMEGmet_2217
MSDMYSTI_00848
MFBMFUL124B02_04805
CCXCOCOR_00721
CFUSCYFUS_005449
MRDMrad2831_6397
MTEADK419_00405
MIVC4E04_06100
RHZRHPLAN_31970
METGHT051_00245
NTDEGO55_06220 EGO55_06680 EGO55_06825
THDBHV28_12810
CAULKCG34_11925 KCG34_11965
AEXAstex_2504
OATOAN307_c19740
TGLHFZ77_15250
PLIAE4191_06175
DAAAKL17_3498
PSEBEOK75_03975
POZI0K15_01515
NARSaro_3532 Saro_3545
NPPPP1Y_AT13638 PP1Y_Mpl5490
NREBES08_24625 BES08_24820
NOVTQ38_005795 TQ38_017245 TQ38_022035 TQ38_023650
NOTC7W88_19500 C7W88_19950
NGFFRF71_08380 FRF71_08390 FRF71_10150
NOGGKE62_04925 GKE62_06540 GKE62_06550
SPHKSKP52_13580
SMAZLH19_04035
SPHQBWQ93_03585
SWISwit_2259
SPHDHY78_14230 HY78_22845 HY78_22850
SPHITS85_08785
SPANAWL63_11370 AWL63_24005
SKRBRX40_00695
SPHAD3Y57_18050
SJPSJA_C1-03930
SINBSIDU_16905
SYBTZ53_04155
SPMIK663_17776 K663_18116
SPHRBSY17_3924 BSY17_543
SHYDCJD35_00570 CJD35_06880
SCLOSCLO_1019010
SBARH5V43_14105
SAMISAMIE_1032770
SPPHKFK14_08000 KFK14_08870 KFK14_13450 KFK14_21620
CIJWG74_05585
SPHGAZE99_02220 AZE99_02570 AZE99_05050
SFLASPHFLASMR4Y_01233(benD) SPHFLASMR4Y_01334(benD) SPHFLASMR4Y_01377(benD) SPHFLASMR4Y_01860(benD) SPHFLASMR4Y_01932(benD)
SPHYCHN51_02990 CHN51_03345 CHN51_03375 CHN51_17560 CHN51_18065
BLASBSY18_620
BFWB5J99_12325
SPHJBSL82_07570 BSL82_07605 BSL82_14320
PARJJ4G78_04415 J4G78_06985 J4G78_13315 J4G78_13345 J4G78_16400 J4G78_17660
PHAOHF685_08370 HF685_13350 HF685_13380 HF685_15840
SMICSmB9_08780 SmB9_08790
SANDH3309_10155 H3309_11070
ALHG6N82_03895 G6N82_09480 G6N82_09490
CMANA9D14_16350 A9D14_16785
ELQGa0102493_111116 Ga0102493_111118 Ga0102493_112074
ERFFIU90_01585
PNSA9D12_03500
PORLBG023_112375 BG023_11266 BG023_11268
PHZCHX26_01065 CHX26_01075 CHX26_13090
POTE2E27_02035
GDIGDI2584
GDJGdia_0818
KNAB0W47_14495
SHUMSTHU_19500
SVCSTVA_17970
NCBC0V82_02450 C0V82_25770
RCERC1_0549
TXITH3_02810
THACCSC3H3_03145
SNEANBZ79_18740
LPARFAM21731_00863
LLAOLHL71_06190
OOEOEOE_0242
OENDSM07_06745
OSIDLJ48_04325
VMAVAB18032_22275
CEPCri9333_2499
PUVPUV_09390
 » show all
Reference
1  [PMID:14214322]
  Authors
DAHM K, BREUER H.
  Title
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]
  Journal
Hoppe Seylers Z Physiol Chem 336:63-8 (1964)
DOI:10.1515/bchm2.1964.336.1.63
Reference
2  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J Biol Chem 232:1015-30 (1958)
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 218:661-74 (1956)
Reference
4  [PMID:193845]
  Authors
Schultz RM, Groman EV, Engel LL
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J Biol Chem 252:3775-83 (1977)
Reference
5  [PMID:13129261]
  Authors
TALALAY P, DOBSON MM.
  Title
Purification and properties of a beta-hydroxysteroid dehydrogenase.
  Journal
J Biol Chem 205:823-37 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.51
IUBMB Enzyme Nomenclature: 1.1.1.51
ExPASy - ENZYME nomenclature database: 1.1.1.51
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.51
BRENDA, the Enzyme Database: 1.1.1.51
CAS: 9015-81-0

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