KEGG ENZYME: 1.1.1.59

ENZYME: 1.1.1.59

Entry

EC 1.1.1.59                 Enzyme

Name

3-hydroxypropionate dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

3-hydroxypropanoate:NAD+ oxidoreductase

Reaction(IUBMB)

3-hydroxypropanoate + NAD+ = 3-oxopropanoate + NADH + H+ [RN:R01608]

Reaction(KEGG)

R01608

Substrate

3-hydroxypropanoate [CPD:C01013];
NAD+ [CPD:C00003]

Product

3-oxopropanoate [CPD:C00222];
NADH [CPD:C00004];
H+ [CPD:C00080]

History

EC 1.1.1.59 created 1965

Pathway

ec00410

beta-Alanine metabolism

ec00640

Propanoate metabolism

ec01100

Metabolic pathways

Orthology

K23146

3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase

Genes

DME:	Dmel_CG15093(CG15093)

DER:

6547189

DSE:

6609855

DSI:	Dsimw501_GD25359(Dsim_GD25359)

DYA:	Dyak_GE13884

DSR:	110178468 110178492

DPO:

4803741

DPE:

6591227

DMN:	108160705 117191284

DWI:

6651391

DGR:

6559410

DMO:	Dmoj_GI20341

DAZ:

108615719

DNV:

108655096

DHE:

111604074

DVI:

6627203

CCAT:

101459752

BOD:

106627239

MDE:

101898222

SCAC:

106089156

LCQ:

111682074

LSQ:

119606477

HIS:

119661518

AGA:	AgaP_AGAP005581

ACOZ:

120949917

AARA:

120897559

AMER:

121592516

ASTE:

118512837

AALI:

118464472

AAG:

5578900

AALB:

109417854 109426815

CQU:	CpipJ_CPIJ015209

CPII:

120413202

CNS:

116350839

BCOO:

119080231

AME:

551208

BIM:

100748925

BTER:

100650674

CCAL:

108631411

OBB:

114880595

SOC:

105199897

MPHA:

105829621

AEC:

105148657

ACEP:

105623652

PBAR:

105423914

HST:

105183984

DQU:

106751759

CFO:

105247857

FEX:

115237303

LHU:

105675093

PGC:

109856102

OBO:

105278581

NVI:

100119485

CSOL:

105359007

MDL:

103570641

CSET:

123308138

BMOR:

100174823(hibadh)

BMAN:

114245382

MSEX:

115444831

DPL:	KGM_210828

BANY:

112043769

NIQ:

126770616

PMAC:

106707996

PPOT:

106107381

PXU:

106121452

PRAP:

111001538

PBX:

123708553

PNAP:

125049561

ZCE:

119832613

CCRC:

123695503

HAW:

110372073

HZE:

124633361

TNL:

113494831

SLIU:

111359807

OFU:

114361986

PXY:

105389772

CFEL:

113372703

BTAB:

109036117

NLU:

111053946

ATH:

AT4G20930

ALY:

9305992

CRB:

17879685

CSAT:

104718244 104722970 104731464

EUS:	EUTSA_v10025955mg

BRP:

103834215

BNA:	106360992 106427509

BOE:

106331744

RSZ:

108819502

THJ:

104806251

CPAP:

110807635

CIT:

102613224

CIC:	CICLE_v10015754mg

PVY:

116107382

MINC:

123205321 123227250

TCC:

18595071

GRA:

105793915

GHI:	107910663 121217706

GAB:

108465045

DZI:

111275382

EGR:

104440683

GMX:	100798272 100814043

GSJ:	114367182 114386757

PVU:	PHAVU_006G127500g

VRA:

106775809

VAR:

108342905

VUN:

114188962

CCAJ:

109803365

APRC:

113866964

MTR:

11408758

TPRA:

123898268

CAM:

101500780

PSAT:

127075300

LJA:	Lj6g3v1629990.1(Lj6g3v1629990.1)

ADU:

107483242

AIP:

107638855

AHF:	112741474 112796184

LANG:

109334356

PCIN:

129285249

FVE:

101306412

RCN:

112166404

PPER:

18780443

PMUM:

103325239

PAVI:

110758641

PDUL:

117624803

MDM:

103435630

MSYL:

126624827

PXB:

103952367

ZJU:	107405597 107405710

MNT:

21408668

CSV:

101210819

CMO:

103488390

BHJ:

120083003

MCHA:

111010940

CMAX:

111495162

CMOS:

111434338

CPEP:

111783548

RCU:

8265515

JCU:

105636845

HBR:

110650572

MESC:

110600137

POP:

7471688

PEU:

105136238

PALZ:

118035874

JRE:

109012874

CILL:

122276100

QSU:	112006083 112035417

QLO:

115991842

TWL:

119988537

VVI:

100242424

VRI:

117922860

SLY:

101265687

SPEN:

107009454

SOT:

102599107

SSTN:

125849198

CANN:

107853316

NTA:	107778120 107813802

NSY:

104211935

NTO:

104113587

NAU:

109234219

INI:

109174135

ITR:

116031380

SIND:

105175798

OEU:

111368685

EGT:

105948759

SSPL:

121746195

APAN:

127249660

HAN:

110878751

ECAD:

122582265

LSV:

111878357

CCAV:

112512592

DCR:

108206577

CSIN:

114291054

BVG:

104901234

CQI:	110702117 110728509

NNU:

104589227

MING:

122078165

TSS:

122649597

PSOM:

113278796 113290220

OSA:

9268115

DOSA:

Os06t0677400-01(Os06g0677400)

OBR:

102711538

OGL:

127775518

BDI:

100838762

ATS:

109781405

TDC:	119332183 119339986

TAES:

123154424 123159992 123167292

TUA:

125522132

LPER:

127312138

SBI:

110431419

ZMA:

100283587

SITA:

101764065

SVS:

117852602

PVIR:

120668435 120704217

PHAI:

112890753

PDA:

103713826

EGU:

105049084

MUS:

103999516

ZOF:	121992046 122039001

DCT:

110111413

PEQ:

110023183

AOF:

109822246

NCOL:

116267445

ATR:

18427315

PPP:

112279665

VCN:	VOLCADRAFT_118095

MNG:

MNEG_6697

CSL:	COCSUDRAFT_17252

APRO:

F751_4388

DHA:	DEHA2A06116g

PIC:	PICST_35865(HIB1)

PGU:	PGUG_03513

SPAA:

SPAPADRAFT_63316

LEL:	LELG_04908

CAL:	CAALFM_C602890CA(HPD1)

CTP:	CTRG_05388

COT:	CORT_0F02180

CDU:	CD36_63190

YLI:	YALI0F02607g

CLU:	CLUG_05312

CLUS:

A9F13_14g00847

CAUR:

CJI96_0004350

SLB:	AWJ20_3507

NCR:

NCU06559

NTE:	NEUTE1DRAFT145029(NEUTE1DRAFT_145029)

SMP:	SMAC_04681

PAN:	PODANS72p054 PODANSg166

TTT:	THITE_2114362

MTM:	MYCTH_2310492

CTHR:

CTHT_0036890

MGR:

MGG_01687

PPEI:

PpBr36_01202

TMN:	UCRPA7_2168 UCRPA7_8112

SSCK:

SPSK_05342

FGR:	FGSG_05284

FPU:	FPSE_07208

FVR:	FVEG_06255

FOX:	FOXG_08423 FOXG_10918 FOXG_12981 FOXG_13122

NHE:	NECHADRAFT_33071 NECHADRAFT_86146 NECHADRAFT_93927 NECHADRAFT_97103 NECHADRAFT_97778

TRE:	TRIREDRAFT_104140

TRR:	M419DRAFT_73258

MAW:

MAC_01431

MAJ:

MAA_07047

CMT:

CCM_00032

PLJ:	VFPFJ_06557 VFPFJ_10197

PTKZ:

JDV02_000005 JDV02_008842 JDV02_008843

VAL:	VDBG_01344

VDA:	VDAG_07909

CFJ:	CFIO01_03841 CFIO01_11654 CFIO01_11658

CHIG:

CH63R_13498

SAPO:

SAPIO_CDS7560

ELA:	UCREL1_3303 UCREL1_4352

PFY:	PFICI_05450 PFICI_07605

SSL:	SS1G_08367

BFU:	BCIN_12g03570

MBE:	MBM_02490 MBM_03263

PSCO:

LY89DRAFT_617415 LY89DRAFT_723046

GLZ:	GLAREA_01875

ANI:

AN0593.2

AFM:	AFUA_6G11020

ACT:	ACLA_084700

AOR:	AO090023000518

ANG:	ANI_1_1106074(An08g07890)

AFV:	AFLA_006864

ALUC:

AKAW2_51629S

ACHE:

ACHE_60140A

APUU:

APUU_10023S APUU_11491S APUU_51405A APUU_51526A APUU_60770S APUU_61096S APUU_61099A APUU_61270S

PCS:	Pc21g20910

PDP:	PDIP_39320

TMF:	EYB26_001108 EYB26_006775 EYB26_008423

TRG:	TRUGW13939_00127 TRUGW13939_00890 TRUGW13939_03169

CIM:	CIMG_00035

CPW:	CPC735_060780

URE:	UREG_00163

PBL:	PAAG_03978

PBN:	PADG_03466

ABE:

ARB_07874

TVE:

TRV_06555

BGH:	BDBG_06544

PNO:	SNOG_04145 SNOG_05709 SNOG_05712

PTE:	PTT_14929 PTT_17331

BZE:	COCCADRAFT_30161 COCCADRAFT_35760 COCCADRAFT_38644

BSC:	COCSADRAFT_132068 COCSADRAFT_144678 COCSADRAFT_168276

BOR:	COCMIDRAFT_81061 COCMIDRAFT_98672 COCMIDRAFT_9903

AALT:

CC77DRAFT_1020606 CC77DRAFT_317829 CC77DRAFT_971877

ZTR:	MYCGRDRAFT_110793

PFJ:	MYCFIDRAFT_154262 MYCFIDRAFT_185924 MYCFIDRAFT_211096 MYCFIDRAFT_56858 MYCFIDRAFT_83007

FFU:	CLAFUR5_03009 CLAFUR5_11198

BCOM:

BAUCODRAFT_39046

NPA:	UCRNP2_10215 UCRNP2_6635

TML:	GSTUM_00004370001

SHS:	STEHIDRAFT_59594

ADL:	AURDEDRAFT_89096

FME:	FOMMEDRAFT_107760 FOMMEDRAFT_118118 FOMMEDRAFT_17459

ABP:	AGABI1DRAFT116631(AGABI1DRAFT_116631)

ABV:	AGABI2DRAFT196100(AGABI2DRAFT_196100)

MRR:	Moror_17718

E1B28_010121

» show all

Reference

1 [PMID:13672942]

Authors

DEN H, ROBINSON WG, COON MJ.

Title

Enzymatic conversion of beta-hydroxypropionate to malonic semialdehyde.

Journal

J Biol Chem 234:1666-71 (1959)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.59

IUBMB Enzyme Nomenclature:

1.1.1.59

ExPASy - ENZYME nomenclature database:

1.1.1.59

BRENDA, the Enzyme Database:

1.1.1.59

CAS:

9028-59-5

All links

Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (413)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (366)   
   KEGG MGENES (46)   
Protein sequence (2)   
   UniProt (2)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
All databases (431)   

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