KEGG   ENZYME: 1.1.3.41
Entry
EC 1.1.3.41                 Enzyme                                 
Name
alditol oxidase;
xylitol oxidase;
xylitol:oxygen oxidoreductase;
AldO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
alditol:oxygen oxidoreductase
Reaction(IUBMB)
an alditol + O2 = an aldose + H2O2 [RN:R11618]
Reaction(KEGG)
R11618 > R07152 R11620
Substrate
alditol [CPD:C00717];
O2 [CPD:C00007]
Product
aldose [CPD:C01370];
H2O2 [CPD:C00027]
Comment
The enzyme from Streptomyces sp. IKD472 and from Streptomyces coelicolor is a monomeric oxidase containing one molecule of FAD per molecule of protein [1,2]. While xylitol (five carbons) and sorbitol (6 carbons) are the preferred substrates, other alditols, including L-threitol (four carbons), D-arabinitol (five carbons), D-galactitol (six carbons) and D-mannitol (six carbons) can also act as substrates, but more slowly [1,2]. Belongs in the vanillyl-alcohol-oxidase family of enzymes [2].
History
EC 1.1.3.41 created 2002, modified 2008
Pathway
ec00040  Pentose and glucuronate interconversions
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K00594  alditol oxidase
Genes
SURSTAUR_8333
RHLLPU83_2792(xyoA)
RGRFZ934_21205
DEIC4375_16190
DSALK1X15_10040
DEVOH4N61_10425
NSMJO391_00330
BCIRC2I06_21335
GRCGI584_06435
NDTL1999_13670
PJDPjdr2_3940
GYMGYMC10_3259
PBVAR543_14140
PYGAWM70_16255
PLWD5F53_13875
PPSCEHS13_31635
PALBEJC50_27860
PPRTET464_13645
PRZGZH47_03155
PLYCGXP70_13305
PCELHUB94_15845
PALRHGI30_02665
COHEAV92_20955
CHEBHH215_15340
AFXJZ786_23950
MLJMLAC_02150(xyoA)
CCYCSCMU_05010
SCOSCO6147(aldo)
SMASAVERM_2090
SCBSCAB_19421
SSXSACTE_6464
SVLStrvi_3645
SHYSHJG_7217
SHOSHJGH_6977
SRCM271_07275
SMALSMALA_6973
SSOII1A49_38635
SFASfla_0209
SBHSBI_09106
SDVBN159_2173(xyoA)
STRPF750_6808
SCIB446_28865
SLVSLIV_07400(xyoA)
SGUSGLAU_26465(xyoA)
SCWTU94_26360
SXISXIM_48790
SAMBSAM23877_5861(xyoA)
SCXAS200_11600
SRWTUE45_06783(xyoA)
STRFASR50_28020
SLEsle_15280(sle_15280)
SPAVSpa2297_25990
STRTA8713_25540
SGSAVL59_12365
STSIA4E84_31690
SGMGCM10017557_16380(xyoA)
SCADDN051_10280
SPHWNFX46_10295
SLSSLINC_6662
STRDNI25_08645
SNWBBN63_04915
SAUOBV401_38490
SPUNBFF78_10425
SALFSMD44_01119
SNZDC008_27635
SGEDWG14_01922(xyoA)
SRJSRO_1690
SDXC4B68_08815
SGDELQ87_08415
SCYAEJ357_36765
SASTCD934_05730
SNQCP978_26600
SNKCP967_33445
SHAWCEB94_32340
SGALCP966_28775
SFYGFH48_10640
SAQUEJC51_36855
SGFHEP81_01873
SSEOD0Z67_23350
SPHVF9278_38515
SFUGCNQ36_26325
SPACB1H29_07660
SCHACP983_09330
SCOECP976_34260
SBATG4Z16_03155
SBROGQF42_33160
STUIGCM10017668_56430(xyoA)
SATAC5746_03840
SCHFIPT68_28830
SHARHUT13_24560
SCYGS1361_30790(xyoA)
SFEUIM697_32150
SLIAHA039_32885
SVDCP969_29735
SPRACP972_28580
SROIIAG44_08270
SDDD9753_07380
SACTDMT42_30285
SMAOCAG99_02390
SLFJEQ17_11545
SDECL3078_36060
SDURM4V62_37135
SCTSCAT_p1150(xyoA)
SCYSCATT_p05820
KSKKSE_59540
KITCFP65_7303
STRIC7M71_018365
STRHGXP74_27500
ABRYNYE86_12660
LXLKDY119_00127(xyoA)
LEIFHF024_17225
LSEF1C12_15575 F1C12_16665
CMICMM_2110
CMSCMS1111(xyoA)
CMCCMN_02075
CMHVO01_09800
CCAPAES38_10310
CZHH9X71_10615
CPHAFGI33_02565
CCAFFGD68_13020
MTSMTES_2201
MIMAKG07_10745
MIXAB663_000424
MCWA8L33_01875
MPALBO218_07510
MIHBJP65_11875
MICRBMW26_15485
MFOLDXT68_14915
MOOBWL13_02828(xyoA)
MLVCVS47_02873(xyoA)
MWAE4K62_02105
MPRTET475_10055
MSFIT882_14350
MCAWF6J84_06005
MLZF6J85_01905
MCHNHCR76_12005
MICSC1N74_03445
MBINLXM64_06975
RTNA6122_2557
RRYC1O28_12095
RIAC7V51_13870
RFSC1I64_14595
RTEGSU10_01560
CUMNI26_11435 NI26_12010
CUBBJK06_12730 BJK06_13355
CUGC1N91_11615 C1N91_12175
CQFGBG65_01645
FRPAX769_01755 AX769_13540
AGYATC03_05180
AGFET445_16960
CARTPA27867_0885
CRYB7495_04410
MALKMalAC0309_2521
MYLC3E77_02515
SALAESZ53_09415
SALDFVA74_03270
HUWFPZ11_11120
GRYD7I44_06630
LYDD7I47_12535
LYKFLP23_08300
PLAPEAO79_08890
MANTBHD05_05825
HEAHL652_16660 HL652_17815
HEHL3i23_18880
FRNF1C15_12780
GLNF1C58_12355
CHREIE160_10800
AGXAGREI_0238(xyoA)
SUBTKPL76_13785
SUBALQ955_13460
ARTArth_4010
ARRARUE_c00520
ARMART_0047
ARWMB46_06040
ARHAHiyo8_36770
ARZAUT26_00260
ARUASPU41_02055
ARQBWQ92_09045
ARNCGK93_00345
ARXARZXY2_3844
ARTHC3B78_00380
AAGINCTC2676_1_02496(xyoA)
ASUNKG104_09145
ARTYAHiyo4_22180
AAUAAur_0055
PUEFV140_00250
PNVJMY29_00295
ACHAchl_0055
APNAsphe3_00510
PSULAU252_13120 AU252_22385
PSNINIBR502771_05040
PSEYGU243_13705 GU243_13780
AAIAARI_02190
GARAOZ07_01250
GMINMP99_01425
SATKSA2016_0475
BCVBcav_2879
BFABfae_29560
BRXBH708_10460 BH708_11690
BGGCFK41_01560
BSAUDWV08_12335
BRRC1N80_04225
BKIM4486_15410
BRHANLU66_00265 NLU66_04800
BHHBra3105_12330
JDEJden_2461
DAYFV141_00960
DERMH7F30_01930
ALXLVQ62_12740
IVAIsova_0124
IDOI598_2577(xyoA)
CETB8281_05070
CCEUCBR64_06400
SKESked_35760
CFLCfla_0930
CFICelf_2955
CELZE5225_13340
CEJGC089_14000
CELHGXP71_01040
CIRALFM56_13670
CELCK5O09_04080
CDONKKR89_04585
CWANKG103_04910
CFENKG102_03255
TEHGKE56_07425
PHWG7075_12550
SERJSGUI_0471
GEZFE251_06345
HALTIM660_05855
RHALLQF10_14005
RSUALQF12_05000
TESBW730_04600
TEZBKM78_03360
TDFH9L22_06490
TLATLA_TLA_00684(xyoA)
PRVG7070_07435
NANOG5V58_03670
NAQUENKNEFLB_00345(xyoA_1)
AERAERYTH_15315
AEZC3E78_12990
AEBC6I20_11465
AEFGEV26_13040
KFLKfla_1819
KQIF1D05_28925
NDANdas_4763
NGVCDO52_16650
NEXNE857_01415
STRREKD16_11800(xyoA)
SROSros_2313
NOABKM31_57625
NOWGBF35_38755
NCXNocox_31680(xyoA)
NGNLCN96_43235
FRIFraEuI1c_5969
ACEAcel_0723
GOBGobs_2565
BSDBLASA_2793(xyoA)
BLAPMVA48_03230
MMARMODMU_2272
KRAKrad_3634
AMDAMED_4426
AMNRAM_22540
AMMAMES_4372
AMZB737_4372
AOIAORI_3521
AJAAJAP_21525(xyoA)
AMYCCU254_14050
AMYBBKN51_14880
AORISD37_18195
APRTMUY14_15230
AROONQK81_04905 NQK81_43810
PBROHOP40_16670
APRECNX65_11710
AMIAmir_2301
SESPBN6_41440
SSYIEKG83_23125
LEDBBK82_04005 BBK82_29275
AHMTL08_13395
ACTIUA75_14945
ACADUA74_14355
AHGAHOG_13485(xyoA)
MAUMicau_4754
MILML5_3543
MICBMicB006_3765
MTUACSH63_00775
MICHFJK98_25225
MTEMGCE86_18290
MCABHXZ27_24090
MSAGGCM10017556_09770(xyoA)
VMAVAB18032_27936
MCRAID554_22805
ASEACPL_1234(xyoA)
AMSAMIS_10070
ACTNL083_5339(xyoA)
AFSAFR_25135
ACTSACWT_1115
AIHAiant_54240(xyoA)
ACTRAsp14428_77070(xyoA)
PLKCIK06_14920
PLABC6361_33815
PLATC6W10_27480
PFLAPflav_087590(xyoA)
PSUUPsuf_050580(xyoA)
VERHUT12_25600
PRYPrubr_10810(xyoA)
CATICS0771_38420(xyoA)
DVCDvina_08045
DFUDfulv_07460
DAURDaura_07430
NHYJQS43_17000
CCAZCOUCH_17345
CAICaci_1977
GLYK3N28_20915
PLANA1s21148_01715
PSUFA1sIA56_06595
JTLM6D93_05395
RMARGBA65_09685
PMETG4Y79_20175
DPDDeipe_4064
FGIOP10G_3204
ACAACP_1928(sox)
ACMAciX9_2118
GMAAciX8_2661
GRWFTO74_13100
GRBGOB94_08210
TSAAciPR4_3451
TRSTerro_0916
TALBFTW19_07175 FTW19_13810
ABASACPOL_5628
EDAGWR55_02480
EDGH7846_14155
ADINH7849_12695
ORPMOP44_09445
PFERIRI77_14560
ABACLuPra_00940(xyoA)
PSEGD3H65_01375
PGINFRZ67_06325
FLCKJS93_03690
HHYHalhy_6020
MGOTMgSA37_01412(xyoA)
MUHHYN43_006085
MGINFRZ54_19475
MGKFSB76_09950
MRUBDEO27_006170
MGOSDIU38_013740
ALMAO498_13110
SLISlin_6373
SRDSD10_21470
SMONAWR27_19060
SPIRCWM47_23165
SPIKEXU85_31715
SPIBG8759_27035
STAEHNV11_03600
SRHOHH216_01275
PSEZHME7025_01300(xyoA)
RHOZGXP67_34265
DFEDfer_3313
DSNHWI92_21455
DYCNFI80_20955
RSIRunsl_5602
RUNDR864_25645
RUPDTQ70_04755
EOLEmtol_3160
FAEFAES_2542
FIBA6C57_08695
MAQALAG90_15890
RTIDC20_00345
ADDHUW48_14060
ASWUHUW51_11355
CHKD4L85_02920
MARBCJ263_03980
EMARD1013_02530
 » show all
Reference
1  [PMID:16232758]
  Authors
Yamashita M, Omura H, Okamoto E, Furuya Y, Yabuuchi M, Fukahi K, Murooka Y
  Title
Isolation, characterization, and molecular cloning of a thermostable xylitol oxidase from Streptomyces sp. IKD472.
  Journal
J Biosci Bioeng 89:350-60 (2000)
DOI:10.1016/S1389-1723(00)88958-6
  Sequence
Reference
2  [PMID:17517896]
  Authors
Heuts DP, van Hellemond EW, Janssen DB, Fraaije MW
  Title
Discovery, characterization, and kinetic analysis of an alditol oxidase from Streptomyces coelicolor.
  Journal
J Biol Chem 282:20283-91 (2007)
DOI:10.1074/jbc.M610849200
Reference
3  [PMID:18154360]
  Authors
Forneris F, Heuts DP, Delvecchio M, Rovida S, Fraaije MW, Mattevi A
  Title
Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase.
  Journal
Biochemistry 47:978-85 (2008)
DOI:10.1021/bi701886t
  Sequence
[sco:SCO6147]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.41
IUBMB Enzyme Nomenclature: 1.1.3.41
ExPASy - ENZYME nomenclature database: 1.1.3.41
BRENDA, the Enzyme Database: 1.1.3.41
CAS: 177322-52-0

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