KEGG   ENZYME: 1.1.5.9
Entry
EC 1.1.5.9                  Enzyme                                 
Name
glucose 1-dehydrogenase (FAD, quinone);
glucose dehydrogenase (Aspergillus);
FAD-dependent glucose dehydrogenase;
D-glucose:(acceptor) 1-oxidoreductase;
glucose dehydrogenase (acceptor);
gdh (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
Sysname
D-glucose:quinone 1-oxidoreductase
Reaction(IUBMB)
D-glucose + a quinone = D-glucono-1,5-lactone + a quinol [RN:R00305]
Reaction(KEGG)
R00305
Substrate
D-glucose [CPD:C00031];
quinone [CPD:C15602]
Product
D-glucono-1,5-lactone [CPD:C00198];
quinol [CPD:C15603]
Comment
A glycoprotein containing one mole of FAD per mole of enzyme. 2,6-Dichloroindophenol can act as acceptor. cf. EC 1.1.5.2, glucose 1-dehydrogenase (PQQ, quinone).
History
EC 1.1.5.9 created 1972 as EC 1.1.99.10, modified 1976, transferred 2013 to EC 1.1.5.9
Pathway
ec00030  Pentose phosphate pathway
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00115  glucose 1-dehydrogenase (FAD, quinone)
K19813  glucose dehydrogenase
Genes
SCLV120338040
DMEDmel_CG1152(Gld) Dmel_CG12398(CG12398)
DER6550630 6552663
DSE6614228 6619575
DSIDsimw501_GD19489(Dsim_Gld) Dsimw501_GD22252(Dsim_GD22252)
DYADyak_GE16083 Dyak_GE25798(Dyak_Gld)
DAN6500095 6502183
DSR110187133 110188374
DPODpse_GA11047(Dpse_Gld) Dpse_GA11607
DPE6594196 6602890
DMN108155759 108155806
DWI6641389 6647536
DGR6563431 6565255
DMODmoj_GI15373 Dmoj_GI23491
DAZ108619300 108621644
DNV108656497 108659449
DHE111591891 111603457
DVI6632342 6633754
CCAT101454164 105664848
BOD106617448 106622824
MDE101900331
SCAC106083621 106085747
LCQ111688970 111689872
LSQ119605705 119607820
HIS119654666 119659534
AGAAgaP_AGAP002557 AgaP_AGAP003786 AgaP_AGAP003787
ACOZ120948784 120952528 120952529
AARA120894054 120898658 120898659
ASTE118502619 118502621 118508258
AAG5563959 5567033
AALB109403259 109433366 115268979
CQUCpipJ_CPIJ007624 CpipJ_CPIJ009583
CPII120421234 120425938
CNS116339623 116349199
BCOO119069454 119071627 119074870
AME100576547 406081 410747 551044 552395
ACER107994729 107994935 107997821 107997822
ALAB122712655 122714921 122715003 122715324 122715325
BIM100744789 100744879 100746983 100747103
BBIF117205104 117205106 117205505 117213918 117213928
BVK117231080 117231081 117237600 117237608 117238744
BVAN117157571 117157573 117161470 117161573 117166274 117166291
BTER100643171 100648192
BPYO122567535 122567536 122568702
CCAL108627041 108627042 108629331 108629344 108629353 108629647 108631246 108631524 108631954
OBB114873510 114873511 114877392 114877393 114880798
MGEN117217492 117217502 117217503 117218409 117219239 117219240 117221871 117221881 117223452
NMEA116429399 116429400 116429403 116429404 116429405 116429406 116429620 116433064 116433065
CGIG122399259 122399261 122400200 122400202 122400206 122400208 122404500
SOC105199137 105203623 105203631
MPHA105831214 105831486 105837234
AEC105147688 105147689 105147781 105148247
ACEP105620277 105620278 105624516 105624557 105625228
PBAR105424264 105432040 105432041 105434306
VEM105561672
HST105183392 105183530 105183533 105186083 105186084
DQU106740547 106740548 106745095 106745096
CFO105250341 105250342 105250729 105250730 105254825 105255565
FEX115237449 115246082
LHU105669518 105673631 105677194 105677195
PGC109857437 109858152 109858155
OBO105280502 105284788 105288220 105288221
PCF106785683 106787242 106787249 106789339
PFUC122517157 122518819 122519477
VPS122628015 122630374 122632652 122632653
NVI100117838 100122870
CSOL105361144 105362648 105365366
TPRE106650785 106653626 111694438
MDL103571767 103574243 106694216
CGLO123263529 123271597 123271605 123271968
FAS105262814 105270301 105270302 105274017 105274028
DAM107036047 107036048 107038334 107038335 107047783
AGIF122847833 122851860 122852246 122859004 122859005 122859006 122860618
CCIN107262975 107262976 107266694 107268620 107268622 107270075
TCA655686 656559 656885 660884
DPA109537240 109542719 109542959 109543052 109544232
SOY115876021 115884134 115884136 115887923
ATD109597896 109602955 109606593 109607920
CSET123306746 123307999 123320328 123320655
AGB108908600 108909978 108915069
LDC111502842 111503079 111505685 111505827 111516443
NVL108561769 108565138 108568493
APLN108732413 108732414 108735429 108735430 108736216 108736923 108737926 108743770 108744373 112904094
PPYR116161140 116161628 116164853
OTU111415468 111417569
BMOR101736123 101739464 101746910
BMAN114245252 114246761 114246813 114252767
MSEX115441341 115442394 115450805 115455627
DPLKGM_206908 KGM_207054 KGM_212710
BANY112055214 112056283 112056301 112057185
PMAC106712727 106714475 106721233
PPOT106106737 106108721 106109938
PXU106117662 106117840 106117958 106122978
PRAP110998269 111002265 111004378 111004407
ZCE119833180 119833668 119836150 119836256
HAW110370826 110370896 110370921 110371713
TNL113502752 113502817 113503094
SLIU111359924 111359988 111360144 111360322
OFU114350862 114350923 114352124 114361905
PXY105385272 105387932 105388044 105388055 105388088 105388388 105396736 105396961
API100162078 100162717 100163673 115034395
DNX107161743 107161744 107163075 107172953
AGS114124191 114129771 114131940 114132894
RMD113549290 113552747 113553641 113558121 113560331
BTAB109030214 109032833 109033999 109034014 109037620
DCI103508295 103512943 103523903
CLEC106661149 106672783 112126917
HHAL106681180 106682454 106683522 112210033
NLU111045055 111045056 111053716
PHUPhum_PHUM254550 Phum_PHUM448870
FOC113201834 113205359 113206863 113207852 113210424 113210757 113213064 113214218 113214220 113214756 113217570
TPAL117639024 117639368 117640299 117642485 117642857 117646112 117646379 117647440 117649305 117650878 117653826 117654261
ZNE110828753 110832325 110832738 110836504 110837956
CSEC111862189 111866731 111867590 111868248 111869389
FCD110849883
HAZT108666307 108680563
PGELG71_17045
IZHFEM41_17375
YENYE1085
YEPYE105_C3004
YEYY11_43071
YEWCH47_501
YETCH48_524
YEFFORC2_1100
YEEYE5303_08381
YALAT01_3557
YFRAW19_277
YKRCH54_1387
YAKACZ76_03680
YCAF0T03_05890
YMOHRD69_19685
SPESpro_2086 Spro_2333
SMAFD781_1913
SLQM495_11635
SRZAXX16_3216
SERMCLM71_09485
SQUE4343_04530 E4343_05775
SFJSAMEA4384070_2146
SRHZFO014_00055
SENPKHA73_10580
RAHRahaq_1025 Rahaq_2268
RACEJHW33_05490 JHW33_21835
RAQRahaq2_1094
RAAQ7S_04895 Q7S_11470
ROXBV494_05650 BV494_23015
RVCJ9880_12955 J9880_18580
GQUAWC35_21125
EAMEGXP68_15395
RBADH2866_20150
SODSant_P0054
EAMEAMY_1955(sldL)
EAYEAM_1912
EBIEbC_03950 EbC_05300 EbC_22450
ERWIGN242_19155
PAMPANA_4103(adhB)
PLFPANA5342_p10259(gdhA3)
PAJPAJ_p0187
PAQPAGR_p190
PAOPat9b_4394 Pat9b_4434 Pat9b_4448 Pat9b_5528 Pat9b_5676
PSTWDSJ_26130
PALHB1H58_10375
PANSFCN45_11170
TCIA7K98_02860 A7K98_07205 A7K98_09125 A7K98_09340 A7K98_11430 A7K98_20775
TPTYNCTC11468_03835
OPODSM2777_00400
PFQQQ39_17155
LABLA76x_0711
LAQGLA29479_2909
LCPLC55x_0563
LGULG3211_0551
LEZGLE_4831
LEMLEN_4593
LCICINQ41_06200
FAUFraau_0213 Fraau_0942 Fraau_1851 Fraau_2283
RHDR2APBS1_0084
RGLCS053_15200
RTHLRK53_00340
LPYFIV34_11170
LANHKR767_15560
PCQPcP3B5_04810(fdhL)
PMUIG4G71_00925
PPUPP_1661
PPFPput_4057
PPWPputW619_3988
PPBPPUBIRD1_3956
PPIYSA_02456
PPXT1E_3660
PFEPSF113_0191
PFOPfl01_4263
PFBVO64_1302
PCGAXG94_16190
PMEDE3Z27_00850
PBAPSEBR_a188
PBCCD58_00820
PDRH681_01525
PKCPKB_0363
PFZAV641_07360 AV641_13015
PPSYAOC04_04065 AOC04_09675
PSOSPOS17_0201
PYMAK972_0889
PGYAWU82_25295
PEZHWQ56_09245 HWQ56_15420
PBZGN234_17230 GN234_19235
PVWHU752_031595
PSAMHU731_006200
PPRGHU725_019640
PANHHU763_015300
PZAHU749_001870
PWYHU734_019120
PTAENCTC10697_01753
ACXAchr_21960
MBAHHYN46_11625 HYN46_15400
SBLSbal_1981
SBMShew185_1996
SBNSbal195_2044
SBPSbal223_2343
SBTSbal678_2045
SBSSbal117_2098
SBBSbal175_2379
CJACJA_3096 CJA_3098
CELLCBR65_19400
MAGAMag101_17590
MCELLPW13_16000
LSHCAB17_12475
MOZMoryE10_02130 MoryE10_16170
NHLNhal_3303
HHUAR456_14575
HAFC8233_01730
ZPLZBT109_1077
CMAIBFX80_08475
CAMHLCW13_09290
IGNMMG00_09095
RSORSc0771
RSLRPSI07_2570
RSMCMR15_30127
RSEF504_790
RSYRSUY_09890(fdhL)
RPIRpic_0719
RPFRpic12D_0789
RMNTK49_08530
RINACS15_0871
RPUCDC45_03985
RSGJK151_18245
CUHBJN34_30875
BMABMAA1245
BMVBMASAVP1_0216
BMLBMA10229_0489
BMNBMA10247_A1083
BMALDM55_4271
BMAEDM78_3899
BMAQDM76_3223
BMAIDM57_10785
BMAFDM51_4906
BMAZBM44_4234
BMABBM45_3357
BPSBPSS0976
BPMBURPS1710b_A2589
BPLBURPS1106A_A1349
BPDBURPS668_A1434
BPSEBDL_4271
BPSMBBQ_5157
BPSUBBN_4439
BPSDBBX_6112
BPZBP1026B_II1071
BPQBPC006_II1360
BPKBBK_3457
BPSHDR55_4356
BPSABBU_5052
BPSOX996_4216
BUTX994_6143
BTEBTH_II1415
BTQBTQ_4702
BTJBTJ_5644
BTZBTL_4185
BTDBTI_5797
BTVBTHA_3774
BTHEBTN_3508
BTHMBTRA_4259
BTHADR62_3580
BTHLBG87_4159
BOKDM82_5143
BOCBG90_5451
BUUWS70_22335
BSAVWS86_23610
BHGI6G56_23080
BVIBcep1808_5084
BVEAK36_3808
BURBcep18194_B1293 Bcep18194_C6549
BCNBcen_3758 Bcen_3815
BCHBcen2424_4553 Bcen2424_4610
BCMBcenmc03_5694 Bcenmc03_5751
BCJBCAM1735 BCAM1790
BCENDM39_6100
BCEWDM40_4560
BCEOI35_5605 I35_5669
BAMBamb_3978
BACBamMC406_4442
BMJBMULJ_04410
BMUBmul_4094
BMKDM80_5403
BMULNP80_4516
BCTGEM_3905
BCEDDM42_6159 DM42_6214
BCEPAPZ15_30355
BDLAK34_3868
BPYRABD05_27245
BCONNL30_03470
BUBBW23_5382
BDFWI26_21785
BLATWK25_25240
BTEIWS51_06245
BSEMWJ12_28605
BPSLWS57_05330
BMECWJ16_27430
BSTGWT74_27740
BSTLBBJ41_21970 BBJ41_22095
BANNJFN94_26685
BUKMYA_4130
BULBW21_5482
BUDAQ610_25785
BUMAXG89_20175
BUIAX768_23085
BURKDM992_31950
BGEBC1002_5233
BPYBphyt_6818
BUZAYM40_22290
BFNOI25_5274 OI25_7039
BCAIK788_0000992
PSPWBJG93_20890
PARABTO02_20365
PARBCJU94_29365
PHSC2L64_31765
PTERC2L65_28495
PCJCUJ87_21800
PTSCUJ90_30365
PMEGFNZ07_06300
PTROG5S35_27850
PGISI6I06_17400 I6I06_18610
PACPFAZ97_22130
PEWKZJ38_36070
CABASBC2_56540(fdhL)
BUOBRPE64_ACDS21180
PUDG9Q38_08460
BOZDBV39_05040
PACRFXN63_21930
PARKLSG25_01235
ACIPCBP36_00070
ACISCBP35_18880
HARHEAR2557
JAZYQ44_10835
JALBZG29_16760
JSVCNX70_17110
JASFJQ89_06195
JLVG3257_17465
HSEHsero_1671
HSZACP92_08300
HHFE2K99_08415
CFUCFU_4430(sldL)
CARELT85_0234 LT85_4991
CPRACPter91_5512
GLCJQN73_08720
MIUABE85_19515
RGUA4W93_28045
XYKGT347_01110
BEBABWI17_11030
HOEIMCC20628_00310
RPODE0E05_02730
ATFAch5_47680
RLURLEG12_00835
NGGRG540_PA11770
NENNCHU2750_41600 NCHU2750_50610
PSCQKHQ08_12965
BQBJ4P68_0027430
XAUXaut_0822
SNOSnov_2174
STARG3545_28605
APRAG3A50_13130
MPHYMCBMB27_05679
MIVC4E04_19920
MSCBN69_1797
MROSEHO51_00295
MEYTM49_09280
PSTGE8M01_28645
KVLKVU_PB0008
KVUEIO_3193
KROBVG79_p1000117(tkrA)
MALGMALG_03027
YANAYJ57_19060 AYJ57_25060
SINLDSM14862_01720(fdhL)
TOMBWR18_01810
HATRC74_19095
PAMIJCM7686_2753
TECAKL02_004830
PSEBEOK75_02310
ZMMZmob_0504
ZMBZZ6_0506
ZMIZCP4_0517
ZMCA265_00511
ZMRA254_00511
ZMPZymop_0463
SPHAD3Y57_01450
GALA0U94_14560
GSPIGS75_00810 IGS75_13945 IGS75_14610
ABGAsbog_00353
BOMBGT348_00910 GT348_07360
AZMDM194_14375
SKTIGS68_32360
SMUCJL100_033440
SROEJL101_028710
SBFJCM31447_15650 JCM31447_28600
NOPNos7524_0267
ROOG5S37_10910
GGRHKW67_00860
FLNFLA_1894
MUCMuYL_2683
NDODDD_3127
HALVNG_1035C
HSLOE_2509R
HDLHALDL1_11140
HHBHhub_2241
HAGSJT689_05485
HABOJRZ79_03985
HNOLT974_06130
HLULT972_07055
HANRLJ422_04245
HJEHacjB3_09625
HALREFA46_011170
HALXM0R89_16915
HMArrnAC0525
HHIHAH_1116
HHNHISP_05725
HABSG26_13385
HTABVU17_05450
HALJG9465_12075
HSINKDQ40_07900
NMONmlp_3548
NHOHWV23_05000
NSALHWV07_11020
HUTHuta_1871
HTIHTIA_1802
HALAHrd1104_12400
HMUHmuk_2378
HALZE5139_15020
HALLLC1Hm_1738(betA)
HAZPGBQ70_15040
HALIBV210_00235
HSNDV733_16425
HDSHSR122_0820(betA)
HLTI7X12_20310
HARCHARCEL1_01480
HWAHQ_3365A
HWCHqrw_3890
HMEHFX_1358(betA)
HGIABY42_06315
HALEG3A49_09665
HBOHbor_19320
HAERDU502_06330
HRAEI982_06995
HLMDV707_08900
HALMFCF25_12105
HLAHlac_0165
HALPDOS48_00835
HALBEKH57_10545
HEZZEO776_00795
HALQHrr1229_006090
HSSJ7656_00400
HSAIHPS36_05915
HAZZKI388_14460
SRUBC2R22_08255
HAEhalTADL_1782
HALNB4589_003515
HALGHUG10_00835
HALUHUG12_20005
HMPK6T50_17015
HREK6T36_17475
HRMK6T25_13690
HACBHbl1158_15060
HAHHalar_1082
HLOJ0X27_12990
HAKZJ0X25_02820
HXAHalxa_2053
NATNJ7G_2196
NPENatpe_0744
NPLFGF80_06910
HALYHYG82_09765
HJTDVR14_13050
HRUHalru_2672
SALIL593_09535
HLCCHINAEXTREME07480
NASGCU68_04030
SAWLNGM29_00435
 » show all
Reference
1  [PMID:6034674]
  Authors
Bak TG.
  Title
Studies on glucose dehydrogenase of Aspergillus oryzae. II. Purification and physical and chemical properties.
  Journal
Biochim Biophys Acta 139:277-93 (1967)
DOI:10.1016/0005-2744(67)90032-0
Reference
2  [PMID:6413974]
  Authors
Cavener DR, MacIntyre RJ
  Title
Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster.
  Journal
Proc Natl Acad Sci U S A 80:6286-8 (1983)
DOI:10.1073/pnas.80.20.6286
Reference
3  [PMID:12770264]
  Authors
Lovallo N, Cox-Foster DL
  Title
Alteration in FAD-glucose dehydrogenase activity and hemocyte behavior contribute to initial disruption of Manduca sexta immune response to Cotesia congregata parasitoids.
  Journal
J Insect Physiol 45:1037-1048 (1999)
DOI:10.1016/S0022-1910(99)00086-4
Reference
4  [PMID:12573242]
  Authors
Inose K, Fujikawa M, Yamazaki T, Kojima K, Sode K
  Title
Cloning and expression of the gene encoding catalytic subunit of thermostable glucose dehydrogenase from Burkholderia cepacia in Escherichia coli.
  Journal
Biochim Biophys Acta 1645:133-8 (2003)
DOI:10.1016/S1570-9639(02)00534-4
  Sequence
Reference
5  [PMID:21903757]
  Authors
Sygmund C, Klausberger M, Felice AK, Ludwig R
  Title
Reduction of quinones and phenoxy radicals by extracellular glucose dehydrogenase from Glomerella cingulata suggests a role in plant pathogenicity.
  Journal
Microbiology 157:3203-12 (2011)
DOI:10.1099/mic.0.051904-0
Reference
6  [PMID:22151971]
  Authors
Sygmund C, Staudigl P, Klausberger M, Pinotsis N, Djinovic-Carugo K, Gorton L, Haltrich D, Ludwig R
  Title
Heterologous overexpression of Glomerella cingulata FAD-dependent glucose dehydrogenase in Escherichia coli and Pichia pastoris.
  Journal
Microb Cell Fact 10:106 (2011)
DOI:10.1186/1475-2859-10-106
Other DBs
ExplorEnz - The Enzyme Database: 1.1.5.9
IUBMB Enzyme Nomenclature: 1.1.5.9
ExPASy - ENZYME nomenclature database: 1.1.5.9
BRENDA, the Enzyme Database: 1.1.5.9
CAS: 37250-84-3

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