KEGG   ENZYME: 1.11.1.12
Entry
EC 1.11.1.12                Enzyme                                 
Name
phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein:peroxidase,glutathione (phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
glutathione:lipid-hydroperoxide oxidoreductase
Reaction(IUBMB)
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O [RN:R03167]
Reaction(KEGG)
R03167;
(other) R07034 R07035 R13043
Substrate
glutathione [CPD:C00051];
hydroperoxy-fatty-acyl-[lipid]
Product
glutathione disulfide [CPD:C00127];
hydroxy-fatty-acyl-[lipid];
H2O [CPD:C00001]
Comment
A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).
History
EC 1.11.1.12 created 1989, modified 2015
Pathway
ec00480  Glutathione metabolism
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K05361  phospholipid-hydroperoxide glutathione peroxidase
Genes
HSA2879(GPX4)
PTR741876(GPX4)
PPS100990361(GPX4)
PON100458624(GPX4)
NLE100601223(GPX4)
MCC705333(GPX4)
MCF102142580(GPX4)
CSAB103233593(GPX4)
CATY105591702(GPX4)
TGE112613047(GPX4)
RRO104671424(GPX4)
RBB108537892(GPX4)
TFN117075813(GPX4)
PTEH111526799(GPX4)
CJC100391793(GPX4) 103790339
SBQ101053315(GPX4)
CSYR103262147(GPX4)
MMUR105860773(GPX4)
LCAT123632821(GPX4)
OGA100963823(GPX4)
MMU625249(Gpx4)
MCAL110303889(Gpx4)
MPAH110326696(Gpx4)
RNO29328(Gpx4)
MCOC116075700(Gpx4)
MUN110551358(Gpx4)
CGE100765235(Gpx4)
MAUA101837194(Gpx4)
PLEU114684123(Gpx4)
MORG121459510(Gpx4)
MFOT126489253
AAMP119820907(Gpx4)
NGI103737339(Gpx4)
HGL101708875(Gpx4)
CPOC100730119(Gpx4)
CCAN109681876(Gpx4)
DORD105990480(Gpx4)
DSP122122854(Gpx4)
NCAR124968734
OPI101530962(GPX4)
TUP102483947(GPX4)
CFA119864793(GPX4)
CLUD112666172(GPX4)
VLG121494565(GPX4)
AML100464258
UMR103681777(GPX4)
UAH113242720(GPX4)
UAR123794043(GPX4)
ELK111161740
LLV125087255
MPUF101678371(GPX4)
ORO101377930(GPX4)
EJU114226343(GPX4)
ZCA113916983(GPX4)
MLX118005304(GPX4)
NSU110594093(GPX4)
FCA101095956(GPX4)
PYU121021417(GPX4)
PBG122488586(GPX4)
LRUF124527695
PTG102949955(GPX4)
PPAD109257691(GPX4)
AJU106978096(GPX4)
HHV120242414(GPX4)
BTA286809(GPX4)
BOM102284111(GPX4)
BIU109561977(GPX4)
BBUB102404388(GPX4)
CHX100860867(GPX4)
OAS101113149(GPX4)
ODA120863712(GPX4)
CCAD122439865(GPX4)
SSC399537(GPX4)
CFR102515650(GPX4)
CBAI105078123(GPX4)
CDK105104118(GPX4)
VPC102544950(GPX4)
BACU103000913(GPX4)
LVE103071491(GPX4)
OOR101270118(GPX4)
DLE111170533(GPX4)
PCAD102992869(GPX4)
PSIU116750457(GPX4)
ECB102147383(GPX4)
EAI106834230(GPX4)
MYB102247160 102257806(GPX4)
MYD102758267(GPX4)
MMYO118659354(GPX4)
MLF102424448(GPX4) 106697200
MNA107534552(GPX4)
PKL118711787(GPX4)
HAI109390605
DRO112312403(GPX4)
SHON118984402(GPX4)
AJM119044582 119044584(GPX4) 119047584
PDIC114503559(GPX4) 114515394
PHAS123813806(GPX4)
MMF118616188(GPX4)
RFQ117037754(GPX4)
PALE102878189(GPX4)
PGIG120583686(GPX4)
PVP105302263(GPX4)
RAY107500914(GPX4)
MJV108388787(GPX4)
TOD119240497(GPX4)
SARA101549194 101556647(GPX4)
LAV100675152(GPX4)
TMU101355012
DNM101428069
MDO100015749(GPX4)
GAS123232218(GPX4)
SHR100930158(GPX4)
PCW110223406(GPX4)
OAA100088643(GPX4)
GGA374056(GPX4)
PCOC116235806(GPX4)
MGP100379155(GPX4)
CJO107325473(GPX4)
NMEL110389092(GPX4)
APLA101796330(GPX4)
AFUL116499031(GPX4)
TGU100190423(GPX4)
LSR110479113(GPX4)
SCAN115483836(GPX4)
PMOA120495770(GPX4)
OTC121342529(GPX4)
PRUF121360999(GPX4)
GFR102045367(GPX4)
FAB101817765(GPX4)
PHI102113402(GPX4)
PMAJ107215549(GPX4)
CCAE111940246(GPX4)
CCW104697013(GPX4)
CBRC103622134(GPX4)
ETL114066400(GPX4)
ZAB102072687(GPX4)
FPG101916317(GPX4)
FCH102055857(GPX4)
CLV102092188(GPX4)
EGZ104127393(GPX4)
NNI104016300(GPX4)
PLET104626575(GPX4)
PCRI104031556(GPX4)
TALA116961654(GPX4)
PADL103922946(GPX4)
AFOR103899414(GPX4)
ACHC115349084(GPX4)
HALD104314809(GPX4)
CCRI104159269(GPX4)
CSTI104557679(GPX4)
EHS104514689(GPX4)
MUI104535977(GPX4)
DPUB104300525(GPX4)
CVF104287163(GPX4)
CUCA104065785(GPX4)
AAM106493531(GPX4)
AROW112965676(GPX4)
NPD112946817(GPX4)
TGT104577742(GPX4)
DNE112988049(GPX4)
SCAM104139528(GPX4)
ASN102386897(GPX4)
AMJ102570581(GPX4)
CPOO109312300(GPX4)
GGN109294939(GPX4)
PSS102460999(GPX4)
CMY102948400(GPX4)
CPIC101944764(GPX4)
TST117869003(GPX4)
CABI116828925(GPX4)
MRV120391529(GPX4)
ACS100563257(gpx4)
PVT110079257(GPX4)
SUND121936901(GPX4)
PBI103065827(GPX4)
PMUR107295211(GPX4)
CTIG120297082(GPX4)
TSR106550757(GPX4)
PGUT117668634(GPX4)
VKO123036606(GPX4)
PMUA114588449(GPX4)
ZVI118087571(GPX4)
GJA107107351(GPX4)
STOW125433909(GPX4)
XLA100036920(gpx4.L) 734888(gpx4.S)
XTR100496541(gpx4)
NPR108789489(GPX4)
RTEM120913798(GPX4)
BBUF120989460(GPX4)
BGAR122920161(GPX4)
DRE352928(gpx4a) 352929(gpx4b)
SRX107723219 107739954
SANH107660382
SGH107552704
CCAR109071199 109095832
PPRM120471296(gpx4b) 120486531(gpx4a)
MAMB125251077(gpx4b) 125252116(gpx4a)
IPU100528418(gpx4b)
PHYP113533158(gpx4)
SMEO124390796(gpx4a) 124403356(gpx4b)
TFD113645121(gpx4b)
AMEX103026361(gpx4)
EEE113585970(gpx4)
TRU101066389 101070699
TNGGSTEN00024700G001 GSTEN00028551G001
LCO104929635 104930512
NCC104958153(gpx4)
CGOB115006643 115023020
ELY117254152(gpx4a) 117272200
EFO125895672(gpx4a) 125902182
PLEP121939387(gpx4a) 121951193
SLUC116037299 116063394(gpx4a)
ECRA117950202(gpx4a) 117953870
ESP116696111(gpx4) 116699145
PFLV114561982(gpx4) 114565634
GAT120815942
PPUG119209805 119216983
MSAM119884432 119900945(gpx4a) 119902192
CUD121512726(gpx4a) 121520718
ALAT119011833 119029309(gpx4a)
MZE101475014 101481366(gpx4)
ONL100696691 100711165
OAU116319194 116327902(gpx4a)
OLA101160642 101160762 111946273
OML112147668 112150257(gpx4a)
XMA102218769 102219707(gpx4)
XCO114147031 114150819(gpx4)
XHE116722172 116725535(gpx4)
PRET103463715(gpx4) 103479268
PFOR103151222 103151223 103155162(gpx4)
PLAI106949670(gpx4) 106961711
PMEI106917758(gpx4) 106918624 106926317
GAF122838806(gpx4a) 122840802
CVG107091856 107095297(gpx4)
CTUL119773700 119790048(gpx4a)
GMU124869953 124873595(gpx4a)
NFU107384121 107393348(gpx4)
KMR108230562(gpx4a) 108239424
ALIM106526245(gpx4)
NWH119407986(gpx4a) 119414633
AOCE111563473 111571007
MCEP125009873(gpx4a) 125011311
CSEM103376758(gpx4) 103395914
POV109625825 109647764
SSEN122780472(gpx4a) 122781861(gpx4b)
HHIP117760019(gpx4a) 117778055
HSP118118007 124854676(gpx4a)
LCF108879022 108883623
SDU111229087 111231965
SLAL111653742(gpx4) 111658891
XGL120790974(gpx4a) 120799459
HCQ109507458 109532270
BPEC110157283 110174007(gpx4)
MALB109966994(gpx4) 109969232
BSPL114845018 114853090(gpx4a)
SASA100194734(gpx4b) 106573579
STRU115157354 115158193
OTW112250826 112252227(gpx4a) 112260797
OMY110506115(gpx4a)
OGO123999099(gpx4a)
ONE115114709
SALP111952959 111957159 111975698
SNH120056116
CCLU121535669 121576785(gpx4a)
ELS105011502 105022279
SFM108919780 108921631
PKI111836622(gpx4) 111860199
AANG118224614(gpx4a) 118230010(gpx4b)
LOC102683270(gpx4)
PSPA121301423
ARUT117428936 117966230
LCM102346539 102365140
CMK103189927
RTP109931453(gpx4)
BFO118421311
BBEL109478343 109484469
CIN100175675(gpx_e)
SCLV120327570
APLC110989974
SKO102807044
RZE108377947 108381437 108381438
AGAAgaP_AGAP004248(GPXH3)
ACOZ120952681
ASTE118517422
AALB109401758
CQUCpipJ_CPIJ006047 CpipJ_CPIJ010637
AME726269
ACER107994450
ALAB122714729
BIM100743362
BBIF117207632
BVK117231056
BVAN117156330
BTER100648859
BPYO122567717
CCAL108626755
OBB114877693
MGEN117219236
NMEA116432653
CGIG122399219
SOC105193617
MPHA105837252
ACEP105625818
PBAR105425460
VEM105566065
HST105183432
DQU106745051
CFO105248391
FEX115245404
LHU105668639
PGC109853223
PCF106790095
PFUC122519916
VPS122631076
NVI100114603 100123141
CSOL105366802
TPRE106652294
MDL106693859
CGLO123265503
FAS105269323
DAM107040528
AGIF122849604 122855894
LHT122504735
CCIN107269072
TCA658307(GLEAN_10355)
DPA109546481
SOY115874706 115877136 115880649 115880650
ATD109596245 109596246 109596247
CSET123306794 123307673 123308152 123309141 123322658
AGB108907641 108907642 108907643
LDC111504102 111512566 111512567
NVL108566482
APLN108732800 108737053 108737061 108737077 112906260
PPYR116180501 116180502
OTU111413348 111413361
DPLKGM_202360 KGM_212277
PPOT106100013
PXU106121901
ZCE119833957
HAW110372557 110372599
HZE124634171
TNL113505368
SLIU111357572 111357612
OFU114360488
CFEL113364132 113364133
AGS114123314
BTAB109035151 109036432
ZNE110827342
CSEC111863272
FCD110842172 110852997
DPXDAPPUDRAFT_220769 DAPPUDRAFT_233749 DAPPUDRAFT_310801
DMK116916349 116916352
PVM113800343
PJA122265622
PCHN125030356
HAME121860142
PCLA123746973
PTRU123511450
HAZT108680142
EAF111699065 111712316
LSM121114086 121114097 121131904
PPOI119099814
ISCIscW_ISCW015098 IscW_ISCW019584 IscW_ISCW022517
DSV119432506 119433848
RSAN119374760 119404627
RMP119176173 119181298
VDE111254008
VJA111259647 111267629 111267630
TUT107368679
DPTE113797481
DFR124494483
CSCU111620010 111620011 111620045
PTEP107457231
SDM118191819
TSPTsp_02268 Tsp_02272
LGILOTGIDRAFT_208098
PCAN112554193 112573590
BGT106061375
GAE121376352
HRF124116706
HRJ124255688 124255701
CRG105330305
MYI110445160
PMAX117325643
MMER123524341
OBI106869007 106874999
OSN115223566 115223910
LAK106176459 106176464
SMMSmp_058690 Smp_058700 Smp_124360
EGLEGR_06748
NVE116621178
EPA110238768 110242483
ATEN116303299
ADF107353881
AMIL114973227
PDAM113682059 113683366
SPIS111325528
DGT114528108
XEN124445385 124447112
HMG100212361 100215761
PSOJPHYSODRAFT_317624
SPARSPRG_01802
EHXEMIHUDRAFT_61670 EMIHUDRAFT_67177
 » show all
Reference
1  [PMID:3978121]
  Authors
Ursini F, Maiorino M, Gregolin C.
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
  Journal
Biochim Biophys Acta 839:62-70 (1985)
DOI:10.1016/0304-4165(85)90182-5
Reference
2  [PMID:8617728]
  Authors
Schnurr K, Belkner J, Ursini F, Schewe T, Kuhn H
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.
  Journal
J Biol Chem 271:4653-8 (1996)
DOI:10.1074/jbc.271.9.4653
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.12
IUBMB Enzyme Nomenclature: 1.11.1.12
ExPASy - ENZYME nomenclature database: 1.11.1.12
BRENDA, the Enzyme Database: 1.11.1.12
CAS: 97089-70-8

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