KEGG   ENZYME: 1.11.1.20
Entry
EC 1.11.1.20                Enzyme                                 
Name
prostamide/prostaglandin F2alpha synthase;
prostamide/PGF synthase;
prostamide F synthase;
prostamide/prostaglandin F synthase;
tPGF synthase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase
Reaction(IUBMB)
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate = thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate [RN:R09506]
Reaction(KEGG)
R09506
Substrate
thioredoxin [CPD:C00342];
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate [CPD:C00427]
Product
thioredoxin disulfide [CPD:C00343];
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate [CPD:C00639]
Comment
The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
History
EC 1.11.1.20 created 2011
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K15717  prostamide/prostaglandin F2alpha synthase
Genes
HSA127281(PRXL2B)
PTR744202(FAM213B)
PPS100989393(PRXL2B)
GGO101134253(PRXL2B)
PON100190803(FAM213B)
NLE100586906(PRXL2B)
MCC695160(PRXL2B)
MCF102136927(PRXL2B)
MTHB126961352
CSAB103225752(FAM213B)
CATY105594459(FAM213B)
PANU101025665(PRXL2B)
TGE112635916(FAM213B)
RRO104664581(PRXL2B)
RBB108526093 108536020(FAM213B)
TFN117093419(PRXL2B)
PTEH111544585(PRXL2B)
CJC100403434(FAM213B)
SBQ101029200(FAM213B)
CSYR103255709(FAM213B)
OGA100946213(FAM213B)
MMU66469(Prxl2b)
MCAL110292660(Fam213b)
MPAH110323558(Fam213b)
RNO362676(Prxl2b)
MCOC116097123(Prxl2b)
MUN110560454(Fam213b)
CGE100755514(Prxl2b)
MAUA101839932(Prxl2b)
PLEU114708266(Prxl2b)
MORG121443586 121448621
MFOT126508201
AAMP119817565(Prxl2b)
NGI103749778(Fam213b)
HGL101722975(Fam213b)
CPOC100733270(Fam213b)
CCAN109691456(Fam213b)
DSP122127368(Prxl2b)
NCAR124994031
TUP102487629(FAM213B)
CFA489616(PRXL2B)
CLUD112646968(PRXL2B)
VVP112924718(PRXL2B)
VLG121500282(PRXL2B)
AML100476330(PRXL2B)
UMR103678433(FAM213B)
UAH113270607(PRXL2B)
UAR123796070(PRXL2B)
ELK111154768
LLV125098949
MPUF101684965(FAM213B)
ORO101379247(FAM213B)
EJU114213396(PRXL2B)
ZCA113939340(PRXL2B)
MLX118020359(PRXL2B)
NSU110579934(PRXL2B)
FCA101090122(FAM213B)
PYU121019479(PRXL2B)
PBG122479830(PRXL2B)
LRUF124516138
PTG102951174(FAM213B)
PPAD109273971(FAM213B)
AJU106984648(PRXL2B)
HHV120242519(PRXL2B)
BTA617001(PRXL2B)
BOM102268856(FAM213B)
BIU109570724(FAM213B)
BBUB102407584(PRXL2B)
CHX102184926(FAM213B)
OAS101120767(PRXL2B)
ODA120880656(PRXL2B)
CCAD122452364(PRXL2B)
SSC100134955(FAM213B)
CFR102509927(PRXL2B)
CBAI105071041(FAM213B)
CDK105106649(PRXL2B)
VPC102545592(PRXL2B)
BACU103000861(FAM213B)
LVE103071802(FAM213B)
OOR101284921(FAM213B)
DLE111187128(PRXL2B)
PCAD102995093(PRXL2B)
PSIU116759306(PRXL2B)
ECB100054405(FAM213B)
EPZ103545047(FAM213B)
EAI106844791(PRXL2B)
HAI109391141(FAM213B)
RFQ117026966(PRXL2B)
PALE102887804(FAM213B)
PGIG120614127(PRXL2B)
PVP105310241(FAM213B)
RAY107510670(FAM213B)
SARA101536925(FAM213B)
LAV100674527(FAM213B)
TMU101348540
MDO100027973(FAM213B)
GAS123255792(PRXL2B)
SHR100932106(PRXL2B)
PCW110200413(FAM213B)
ASN102371358(FAM213B)
AMJ102569997(FAM213B)
CPOO109314495(FAM213B)
GGN109293540(FAM213B)
PSS102455880(FAM213B)
CMY102948080(PRXL2B)
CPIC101934510(PRXL2B)
TST117867831(PRXL2B)
CABI116815392(PRXL2B)
MRV120387816(PRXL2B)
PVT110088238(FAM213B)
PMUA114602569(PRXL2B)
ZVI118087844(PRXL2B)
GJA107110400(FAM213B)
STOW125445430(PRXL2B)
XLA447017(prxl2b.L)
XTR549974(prxl2b)
NPR108783702(FAM213B)
RTEM120915711(PRXL2B)
BBUF120999182(PRXL2B)
BGAR122926843(PRXL2B)
DRE406605(prxl2b)
SRX107712975 107756615
SANH107654427 107702003
SGH107582414 107592888
CCAR109098633
CAUA113055415(prxl2b)
PPRM120480845(prxl2b)
MAMB125256639(prxl2b)
IPU108254989(prxl2b)
PHYP113537949(prxl2b)
SMEO124402060(prxl2b)
TFD113657185(prxl2b)
AMEX103027709(fam213b)
TRU101064795(prxl2b)
TNGGSTEN00002808G001 GSTEN00027565G001
LCO104919355(prxl2b)
NCC104955273(fam213b)
CGOB115008443(prxl2b)
ELY117256418(prxl2b)
EFO125896486(prxl2b)
PLEP121953555(prxl2b)
SLUC116051307(prxl2b)
ECRA117943159(prxl2b)
ESP116688070(prxl2b)
PFLV114553644(prxl2b)
GAT120835746(prxl2b)
PPUG119194034(prxl2b)
MSAM119885718(prxl2b)
CUD121504156(prxl2b)
ALAT119021145(prxl2b)
MZE101467269(fam213b)
ONL100710550(prxl2b)
OAU116316511(prxl2b)
OLA101173382(fam213b)
OML112145312(prxl2b)
XMA102226891(fam213b)
XCO114135769(prxl2b)
XHE116710674(prxl2b)
PRET103464468(fam213b)
PFOR103136509(fam213b)
PLAI106956446(fam213b)
PMEI106926086(fam213b)
GAF122834478(prxl2b)
CVG107087519(fam213b)
CTUL119772771(prxl2b)
GMU124856148(prxl2b)
NFU107385267(fam213b)
KMR108231542(prxl2b)
ALIM106513842(fam213b)
NWH119411824(prxl2b)
AOCE111588019(fam213b)
MCEP125006154(prxl2b)
CSEM103385682(fam213b)
POV109638523(fam213b)
SSEN122768689(prxl2b)
HHIP117761412(prxl2b)
HSP118102623(prxl2b)
LCF108899895(prxl2b)
SDU111223974(fam213b)
SLAL111657924(fam213b)
XGL120783443(prxl2b)
HCQ109529232(fam213b)
BPEC110166956(fam213b)
BSPL114855743(prxl2b)
SASA106582827(fam213b)
STRU115150906(prxl2b)
OTW112254326(prxl2b)
OMY110527842(prxl2b)
OGO124031526(prxl2b)
ONE115136777(prxl2b)
SALP111969820(fam213b)
SNH120064947(prxl2b)
CCLU121578739(prxl2b)
ELS105017396(prxl2b)
SFM108918216(prxl2b)
AANG118211691(prxl2b)
LOC102682812(fam213b)
PSPA121328415(prxl2b)
ARUT117425520 117969679
LCM102361632(FAM213B)
RTP109939063
BFO118429862
BBEL109472697
CIN100184332
SCLV120328807
SPU591310
APLC110985701
BCOO119070364
BMOR101742192
BMAN114249548
MSEX115456332
DPLKGM_201654
BANY112049805
PMAC106709420
PPOT106108897
PXU106125689
PRAP111000037
ZCE119836031
HAW110382629
HZE124642916
TNL113507591
SLIU111358085
OFU114352771
PXY105383581 105388714
CFEL113367431
FCD110852137
DPXDAPPUDRAFT_231765
DMK116931219
PVM113809215
PJA122249212
PCHN125030920
HAME121861186
PCLA123761958
PTRU123510753
HAZT108664354
EAF111699676
PPOI119106348
DSV119445319
RSAN119390926
RMP119167968
SDM118196814
LGILOTGIDRAFT_235844
PCAN112557854
BGT106052380
HRF124117723
HRJ124257496
CRG105330608 105339209
MYI110460228
PMAX117345148
MMER123526940
LAK106156095 106175694
SMMSmp_194940
EGLEGR_01663
NVE5504619
EPA110247772
ATEN116296525
ADF107339164
AMIL114960027
PDAM113664245
SPIS111332461
DGT114517949
HMG100204118
AQU100632965 100633093 100640356
PPP112283185 112290260
FFUCLAFUR5_14586
EHXEMIHUDRAFT_351232 EMIHUDRAFT_369957
 » show all
Reference
1  [PMID:18006499]
  Authors
Moriuchi H, Koda N, Okuda-Ashitaka E, Daiyasu H, Ogasawara K, Toh H, Ito S, Woodward DF, Watanabe K
  Title
Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily.
  Journal
J Biol Chem 283:792-801 (2008)
DOI:10.1074/jbc.M705638200
  Sequence
[ssc:100134955]
Reference
2  [PMID:20950588]
  Authors
Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A
  Title
Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system.
  Journal
Brain Res 1367:22-32 (2011)
DOI:10.1016/j.brainres.2010.10.019
  Sequence
[mmu:66469]
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.20
IUBMB Enzyme Nomenclature: 1.11.1.20
ExPASy - ENZYME nomenclature database: 1.11.1.20
BRENDA, the Enzyme Database: 1.11.1.20

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