KEGG ENZYME: 1.13.11.19

ENZYME: 1.13.11.19

Entry

EC 1.13.11.19               Enzyme

Name

cysteamine dioxygenase;
ADO (gene name);
persulfurase;
cysteamine oxygenase;
cysteamine:oxygen oxidoreductase

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

2-aminoethanethiol:oxygen oxidoreductase

Reaction(IUBMB)

cysteamine + O2 = hypotaurine [RN:R02467]

Reaction(KEGG)

R02467

Substrate

cysteamine [CPD:C01678];
O2 [CPD:C00007]

Product

hypotaurine [CPD:C00519]

Comment

A non-heme iron protein that is involved in the biosynthesis of taurine. 3-Aminopropanethiol (homocysteamine) and 2-sulfanylethan-1-ol (2-mercaptoethanol) can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3].

History

EC 1.13.11.19 created 1972, modified 2006

Pathway

ec00430

Taurine and hypotaurine metabolism

ec01100

Metabolic pathways

Orthology

K10712

cysteamine dioxygenase

Genes

HSA:	84890(ADO)

PTR:	748534(ADO)

PPS:	100991144(ADO)

GGO:	101136773(ADO)

PON:	100452250(ADO)

NLE:	100602024(ADO)

MCC:	698259(ADO)

MCF:	102116205(ADO)

MTHB:

126962160

CSAB:

103216129(ADO)

CATY:

105581496(ADO)

PANU:

101022242(ADO)

TGE:	112631511(ADO)

RRO:	104655645(ADO)

RBB:	108533154(ADO)

TFN:	117082116(ADO)

PTEH:

111537960(ADO)

CANG:

105513255(ADO)

CJC:	100405905(ADO)

SBQ:	101033067(ADO)

CSYR:

103272752(ADO)

MMUR:

105870253(ADO)

LCAT:

123649933(ADO)

PCOQ:

105821115(ADO)

OGA:	100951939(ADO)

MMU:	211488(Ado)

MCAL:

110303950(Ado)

MPAH:

110326811(Ado)

RNO:	309732(Ado)

MCOC:

116101404(Ado)

MUN:	110547602(Ado)

CGE:

113833430

MAUA:

101834006(Ado)

PLEU:

114698524(Ado)

MORG:

121450720(Ado)

MFOT:

126501299

AAMP:

119822761(Ado)

NGI:	103737475(Ado)

HGL:	101713027(Ado)

CPOC:

101787186(Ado)

CCAN:

109676110 109700462(Ado)

DORD:

105986345(Ado)

DSP:	122121442 122122307(Ado)

NCAR:

124985512

OCU:

103351357

OPI:	101531651(ADO)

TUP:	102479881(ADO)

GVR:	103607839(ADO)

CFA:	489003(ADO)

CLUD:

112651214(ADO)

VVP:	112931044(ADO)

VLG:	121487977(ADO)

AML:	100479309(ADO)

UMR:	103667994(ADO)

UAH:	113259090(ADO)

UAR:	123782982(ADO)

ELK:

111144878

LLV:

125084873

MPUF:

101680827(ADO)

ORO:	101372697(ADO) 101378375

EJU:	114204659 114224771(ADO)

ZCA:	113923752(ADO) 113927339

MLX:	118019594 118020090

NSU:	110589170(ADO)

LWW:	102730952(ADO)

FCA:	101082264(ADO)

PYU:	121036677(ADO)

PBG:	122492797(ADO)

LRUF:

124506837

PPAD:

109264307(ADO)

AJU:	113600159(ADO)

HHV:	120247451(ADO)

BTA:	100297937(ADO)

BOM:	102276184(ADO)

BBUB:

102393751(ADO)

BBIS:

105001253(ADO)

CHX:	102174627(ADO)

OAS:	101121567(ADO)

ODA:	120865231(ADO)

CCAD:

122446522(ADO)

SSC:	100153304(ADO)

CFR:	116667169(ADO)

CBAI:

105071295(ADO)

CDK:	105093860(ADO)

VPC:	102545758(ADO)

BACU:

103000138(ADO)

LVE:	103087408(ADO)

OOR:	101273659(ADO)

DLE:	111167611(ADO)

PCAD:

102985453(ADO)

PSIU:

116741970(ADO)

ECB:	100147027(ADO)

EPZ:	103548677(ADO)

EAI:	106826174(ADO)

MYB:	102256478(ADO)

MYD:	102761687(ADO)

MMYO:

118670049(ADO)

MLF:	102430617(ADO)

MNA:	107543266(ADO)

PKL:	118719207(ADO)

HAI:	109380639(ADO)

DRO:	112305525(ADO)

SHON:

118998496(ADO)

AJM:	119055718(ADO)

PDIC:

114497918(ADO)

PHAS:

123820896(ADO)

MMF:	118632484(ADO)

RFQ:	117035959(ADO)

PALE:

102883157(ADO)

PGIG:

120609414(ADO)

PVP:	105298811(ADO)

RAY:	107517964(ADO)

MJV:	108392948(ADO)

TOD:	119234043(ADO)

SARA:

101538393(ADO)

LAV:	100671174(ADO)

TMU:

101342381

ETF:	101651245(ADO)

DNM:	101428176(ADO)

MDO:	100017045(ADO)

GAS:	123234420(ADO) 123255166

SHR:	116421991(ADO)

PCW:	110216373(ADO)

OAA:	100079506(ADO)

GGA:	107053634(ADO)

PCOC:

116235106(ADO)

CJO:	107315686(ADO)

APLA:

113844390(ADO)

AFUL:

116491538(ADO)

TGU:	115495853(ADO)

LSR:	110473322(ADO)

PMOA:

120507240(ADO)

OTC:	121336160(ADO)

PRUF:

121357458(ADO)

FAB:	101819629(ADO)

PHI:	102107641(ADO)

PMAJ:

107207126(ADO)

CCW:	120410198(ADO)

ETL:

114073543

ZAB:	102072657(ADO)

TALA:

116964492(ADO)

ACHC:

115348363(ADO)

HLE:	104832009(ADO)

AGEN:

126042503

GCL:

127018077

NPD:	112950509(ADO)

AMJ:	102567096(ADO)

CPOO:

109312432(ADO)

CMY:	119566776(ADO)

CPIC:

101931118(ADO)

TST:	117880544(ADO)

CABI:

116822445(ADO)

MRV:	120369373(ADO)

PVT:	110078729(ADO)

SUND:

121927030(ADO)

PMUR:

114922597(ADO)

CTIG:

120306431(ADO)

PGUT:

117676138(ADO)

VKO:	123018169(ADO)

PMUA:

114597168(ADO)

ZVI:	118096464(ADO)

GJA:	107112662(ADO)

STOW:

125438365(ADO)

XLA:	108697364(ado.S) 494774(ado.L)

XTR:	100485786(ado)

NPR:	108804787(ADO)

RTEM:

120947052(ADO)

BBUF:

121004642(ADO)

BGAR:

122941063(ADO)

DRE:	406474(adob) 494091(adoa)

SRX:	107719329 107732747 107739062 107745676 107745677

SANH:

107653960 107664434 107695516 107703543

SGH:	107561692 107593521 107596610 107596613

CCAR:

109052668 109100039 109107231 109107242

CAUA:

113056332 113060565 113111927 113117099

PPRM:

120464009(adoa) 120475812(adob)

MAMB:

125255674(adoa) 125268988(adob)

IPU:	108270460(adob) 108273399(adoa)

PHYP:

113527133 113538746

SMEO:

124388383(adoa) 124390431(adob)

TFD:	113649369(adoa) 113659785(adob)

AMEX:

103032129 103046195

EEE:	113583333 113584632

TRU:	101064686 101074983(ado)

TNG:	GSTEN00008477G001 GSTEN00034580G001

LCO:	104924320 104935916

NCC:	104946380(ado) 104965501

CGOB:

115004579 115005543 115025114

ELY:	117247682(adoa) 117247798(adob)

EFO:	125881020(adoa) 125903726(adob)

PLEP:

121954598(adob) 121958737(adoa)

SLUC:

116056395(adob) 116067511(adoa)

ECRA:

117937217(adoa) 117960758

ESP:	116671545(ado) 116679137

PFLV:

114548267(ado) 114572434

GAT:	120819585(adoa) 120820282

PPUG:

119213270(adoa) 119213898(adob)

MSAM:

119912148(adob) 119916199(adoa)

CUD:	121511504(adob) 121527922

ALAT:

119010434(adoa) 119034074

MZE:	101465833 101471343

ONL:	100711871 100711878

OAU:	116320181(adoa) 116335532

OLA:	101157575 110016496

OML:	112162102(adob) 112162338(adoa)

XMA:	102220352 102235164

XCO:	114138062 114150607

XHE:	116712955 116713785 116727712(ado)

PRET:

103477378 103482206(ado)

PFOR:

103131660 103149020

PLAI:

106939641 106959984

PMEI:

106909231 106916187

GAF:	122823103(adoa) 122842818(adob)

CVG:	107087618(ado) 107097159

CTUL:

119787357 119795757(adoa)

GMU:	124858916(adob) 124875432(adoa)

NFU:	107373913 107396840(ado)

KMR:	108245155(adoa) 108246615(adob)

ALIM:

106527984 106534741

NWH:	119419747(adob) 119424088

AOCE:

111562823 111569200

MCEP:

125018610(adob) 125022991(adoa)

CSEM:

103381678(ado)

POV:	109627147(ado) 109647914

SSEN:

122760055(adoa) 122763063

HHIP:

117752399(adoa) 117776051(adob)

HSP:	118101046(adoa) 118119295(adob)

LCF:	108872892 108876784(adoa)

SDU:	111224250 111237081(ado)

SLAL:

111653567 111664279(ado)

XGL:	120794894(adoa) 120796542(adob)

HCQ:	109510061 109529318(ado)

BPEC:

110153143 110154204(ado)

MALB:

109953420 109966662

BSPL:

114846396 114846408 114870686(adob)

SASA:

100195766(aedo) 106591225 106607859 106613884

STRU:

115153286 115189551 115189552 115193671

OTW:	112240379 112253109 112255237

OMY:	110502543 110511817 110519246 110529936

OGO:	124017094 124021820 124040740

ONE:	115113168 115121207 115135035

SALP:

111951991 111978610 112078271

SNH:	120017949 120038386 120039584 120046591

CCLU:

121553524(adob) 121583264 121584714 123490653

ELS:	105010537 105026306(ado)

SFM:	108932788 108939586(ado)

PKI:	111853679(ado) 111858150

AANG:

118218263(adob) 118219457(adoa)

LOC:	102685727(ado)

PSPA:

121321451 121325108

ARUT:

117415303 117418085

PSEX:

120540419

LCM:	102349105 102349371

CMK:	103181026(adoa)

RTP:	109918800(ado)

BFO:

118412943

BBEL:

109471516

SPU:

582096

APLC:

110977046

AJC:

117111005

SKO:

100367728

DME:	Dmel_CG7550(CG7550)

DER:

6543672

DSE:

6607845

DSI:	Dsimw501_GD13021(Dsim_GD13021)

DYA:	Dyak_GE20374

DAN:

6493353

DSR:

110189066

DPO:

4814168

DPE:

6599605

DMN:

108151986

DWI:

6643155

DGR:

6558773

DMO:	Dmoj_GI11999

DAZ:

108614657

DNV:

108651581

DHE:

111601734

DVI:

6624608

CCAT:

101463338

BOD:

106614120

RZE:

108358231

MDE:

101894845

SCAC:

106092062

LCQ:

111678517

LSQ:

119607977

HIS:

119649673

AGA:	AgaP_AGAP006807

ACOZ:

120947890

AARA:

120894769

ASTE:

118513491

AAG:

5571697

AALB:

109405169 109408026

CQU:	CpipJ_CPIJ004549

CPII:

120429157

CNS:

116338854

BCOO:

119081220

AME:

724666

ACER:

107993536

ALAB:

122715447

BIM:

100746274

BBIF:

117216179

BVK:

117241927

BVAN:

117159854

BTER:

100643470

BPYO:

122568051

CCAL:

108622031 108628408

OBB:

114875961

MGEN:

117218416

NMEA:

116433371

CGIG:

122399416

SOC:

105198180

MPHA:

105833737

AEC:

105151949

ACEP:

105625013

PBAR:

105424153 105428986

VEM:

105565220

HST:

105183995

DQU:

106746200

FEX:

115237060

LHU:

105679866

PGC:

109860287

OBO:

105282374

PCF:

106791493

PFUC:

122517456

VPS:

122629223

NVI:

100123227

CSOL:

105368049

TPRE:

106659597

MDL:

103573176

CGLO:

123275434

FAS:

105272185

DAM:

107043258

AGIF:

122854372

CCIN:

107263121

TCA:

663771

DPA:

109542797

SOY:

115880163

ATD:

109599098

CSET:

123313195

AGB:

108917686

LDC:

111512073

NVL:

108562236

APLN:

108736482 112906418

PPYR:

116176705

OTU:	111415160 111419054

BMOR:

101739372

BMAN:

114244255

MSEX:

115442833

DPL:	KGM_207212

BANY:

112053317

NIQ:

126778250

PMAC:

106720496

PPOT:

106102945

PXU:

106116159

PRAP:

110997264

PBX:

123715547

ZCE:

119837806

CCRC:

123702862

HAW:

110373588

HZE:

124641798

TNL:

113495500

SLIU:

111357250

OFU:

114356065

API:

100163420

DNX:

107164682

AGS:

114124423

RMD:

113548361

BTAB:

109043882

DCI:

103517497

CLEC:

106666739

HHAL:

106679570

NLU:	111048066 120348727

PHU:	Phum_PHUM289820

FOC:

113208597

TPAL:

117653448

ZNE:

110834893

CSEC:

111866936

SGRE:

126354711

FCD:

110851131

DPX:	DAPPUDRAFT_33990

DMK:

116917203

PVM:

113810371

PJA:

122243663

PCHN:

125037216

HAME:

121865170

PCLA:

123759462

PTRU:

123505367

HAZT:

108674529

EAF:

111707871

LSM:	121118317 121123889

PPOI:

119114823

ISC:	IscW_ISCW024001

DSV:

119446703

RSAN:

119389480

RMP:

119181717

VDE:

111248813

VJA:

111270102

TUT:

107368105

DPTE:

113797786

DFR:

124491452

CSCU:

111620740

PTEP:

107450775

SDM:

118205214

BMY:	BM_BM6707(Bm6707)

LOA:	LOAG_10003

TSP:

Tsp_04201

HRO:	HELRODRAFT_124593

LGI:	LOTGIDRAFT_123657

PCAN:

112563606

BGT:

106061337

GAE:

121383353

HRF:	124137622 124138050

HRJ:	124267542 124284827

CRG:

105321217

MYI:

110464677

PMAX:

117339918

MMER:

123546598

OBI:

106869111

OSN:	115226919 115229697 115231080

LAK:

106153676

SMM:	Smp_118780

SHX:	MS3_00004742

OVI:	T265_10643

EGL:

EGR_05074

NVE:

5507566

EPA:

110250879

ATEN:

116306309

ADF:

107334487

AMIL:

114976328

PDAM:

113668893

SPIS:

111326167

DGT:

114543433

XEN:

124434642

HMG:

100208908

TAD:	TRIADDRAFT_58321

AQU:

100637030

DDI:	DDB_G0273031 DDB_G0274043

DPP:	DICPUDRAFT_152760

TET:	TTHERM_000723389

PTM:	GSPATT00002373001 GSPATT00006838001 GSPATT00032915001

PIF:	PITG_02792

TBR:	Tb927.7.5810

TCR:	508173.129

» show all

Reference

1 [PMID:5912113]

Authors

Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT.

Title

The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme.

Journal

J Biol Chem 241:3189-96 (1966)

Reference

2 [PMID:6052430]

Authors

Wood JL, Cavallini D.

Title

Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor.

Journal

Arch Biochem Biophys 119:368-72 (1967)
DOI:10.1016/0003-9861(67)90467-5

Reference

3 [PMID:1157952]

Authors

Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A.

Title

The specificity of cysteamine oxygenase.

Journal

FEBS Lett 56:348-51 (1975)
DOI:10.1016/0014-5793(75)81124-0

Reference

4 [PMID:3657558]

Authors

Richerson RB, Ziegler DM.

Title

Cysteamine dioxygenase.

Journal

Methods Enzymol 143:410-5 (1987)
DOI:10.1016/0076-6879(87)43071-1

Reference

5 [PMID:17581819]

Authors

Dominy JE Jr, Simmons CR, Hirschberger LL, Hwang J, Coloso RM, Stipanuk MH

Title

Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.

Journal

J Biol Chem 282:25189-98 (2007)
DOI:10.1074/jbc.M703089200

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.19

IUBMB Enzyme Nomenclature:

1.13.11.19

ExPASy - ENZYME nomenclature database:

1.13.11.19

BRENDA, the Enzyme Database:

1.13.11.19

CAS:

9033-41-4

DBGET integrated database retrieval system