Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy

2-aminoethanethiol:oxygen oxidoreductase

cysteamine + O2 = hypotaurine [RN:R02467]

R02467
Reaction

cysteamine [CPD:C01678];
O2 [CPD:C00007]

A non-heme iron protein that is involved in the biosynthesis of taurine. 3-Aminopropanethiol (homocysteamine) and 2-sulfanylethan-1-ol (2-mercaptoethanol) can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3].

EC 1.13.11.19 created 1972, modified 2006

1  [PMID:5912113]

Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT.

The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme.

J Biol Chem 241:3189-96 (1966)

2  [PMID:6052430]

Wood JL, Cavallini D.

Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor.

Arch Biochem Biophys 119:368-72 (1967)
DOI:10.1016/0003-9861(67)90467-5

3  [PMID:1157952]

Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A.

The specificity of cysteamine oxygenase.

FEBS Lett 56:348-51 (1975)
DOI:10.1016/0014-5793(75)81124-0

4  [PMID:3657558]

Richerson RB, Ziegler DM.

Cysteamine dioxygenase.

Methods Enzymol 143:410-5 (1987)
DOI:10.1016/0076-6879(87)43071-1

5  [PMID:17581819]

Dominy JE Jr, Simmons CR, Hirschberger LL, Hwang J, Coloso RM, Stipanuk MH

Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.

J Biol Chem 282:25189-98 (2007)
DOI:10.1074/jbc.M703089200