KEGG   ENZYME: 1.13.11.31
Entry
EC 1.13.11.31               Enzyme                                 
Name
arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 12-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN:R01596]
Reaction(KEGG)
R01596
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [CPD:C05965]
Comment
The product is rapidly reduced to the corresponding 12S-hydroxy compound.
History
EC 1.13.11.31 created 1983
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K00458  arachidonate 12-lipoxygenase
Genes
HSA239(ALOX12)
PTR455242(ALOX12) 455243
PPS100992721(ALOX12) 100993999
GGO101140132(ALOX12)
PON100435170 100448016
NLE100605486(ALOX12)
MCC713748(ALOX12)
MCF102136652(ALOX12) 102137290
MTHB126939829
CSAB103242265(ALOX12)
CATY105582822(ALOX12)
PANU101012932(ALOX12)
TGE112609056(ALOX12) 112609713
RRO104673348(ALOX12)
RBB108514395(ALOX12)
TFN117067814(ALOX12)
PTEH111521261(ALOX12)
CJC100400641(ALOX12)
SBQ101051396(ALOX12)
CSYR103255116 103263245(ALOX12) 103263247
MMUR105878109(ALOX12) 105879294
LCAT123650840(ALOX12)
OGA100951876(ALOX12) 100961111
MMU11684(Alox12) 11685(Alox12e)
MCAL110304778(Alox12)
MPAH110331792(Alox12)
RNO287454(Alox12) 303252(Alox12e)
MCOC116077965
MUN110540751(Alox12)
CGE100764620(Alox12)
MAUA101839190 101844629
PLEU114693220(Alox12)
MORG121456507 121456764
MFOT126513995 126514127
AAMP119812811 119813474
NGI103752172(Alox12)
HGL101702123(Alox12)
CPOC100719400
CCAN109682903(Alox12)
DORD105983295 105983533(Alox12)
DSP122100378(Alox12)
NCAR124979056 124980537
OCU100340525(ALOX12)
OPI101518253(ALOX12)
TUP102493396(ALOX12) 102494779
CFA479476(ALOX12)
CLUD112647510
VVP112924805
VLG121500195
AML100471037(ALOX12)
UMR103660455(ALOX12)
UAH113271099(ALOX12)
UAR123792172(ALOX12)
ELK111161172
LLV125086719 125087074
MPUF101684639(ALOX12)
ORO101379600(ALOX12)
EJU114225417(ALOX12)
ZCA113907925(ALOX12) 113939134
MLX117999898 117999978(ALOX12)
NSU110584560(ALOX12)
FCA101094304
PYU121016040(ALOX12)
PBG122484839
LRUF124519666
PTG102969788(ALOX12)
PPAD109245992
AJU106972408
HHV120231410(ALOX12)
BTA407169(ALOX12) 787450(ALOX12E)
BOM102284543(ALOX12)
BIU109574004(ALOX12)
BBUB102395651(ALOX12)
CHX102187263(ALOX12)
OAS101113685(ALOX12)
ODA120866088(ALOX12)
CCAD122446320 122446338(ALOX12)
SSC100620614(ALOX12)
CFR102504047(ALOX12)
CBAI105077467(ALOX12)
CDK105103060(ALOX12)
VPC102533742(ALOX12)
BACU103020542(ALOX12)
LVE103074060(ALOX12)
OOR101279538(ALOX12)
DLE111185974(ALOX12)
PCAD102977395(ALOX12)
PSIU116745598(ALOX12)
ECB100072916
EPZ103561430(ALOX12)
EAI106844160(ALOX12)
MYB102246619 102248372 102248722 102248980 102249269 102249301 102249603 102249899 102254447(ALOX12) 102255394
MYD102753778 102755565 102755847 102768484 102769301 102769599
MMYO118672025 118672026 118672027 118672028
MLF102428351 102428552 102428668 102428965 102429158 102429663 102429971 102432805 102433118 102435623
MNA107544244(ALOX12)
PKL118726716(ALOX12) 118726717 118726718 118726720 118726721 118727040 118727041 118727042
HAI109394599(ALOX12)
DRO112308919(ALOX12)
SHON118979425(ALOX12)
AJM119037160(ALOX12)
PHAS123809459
MMF118634472 118634597 118634882
RFQ117013802(ALOX12)
PALE102897481(ALOX12)
PGIG120612187(ALOX12)
PVP105291977(ALOX12)
RAY107509504(ALOX12)
MJV108401224(ALOX12)
TOD119232717
SARA101547220(ALOX12) 101547484
LAV100656524
TMU101341400
DNM101444550
MDO100015746(ALOX12) 100015831 100015867 100015906 100015945
GAS123243728 123247715
SHR100933073
PCW110194257
OAA100079469
DRE322732(alox12)
SRX107749792 107750578
SANH107669199
SGH107593795
CCAR109050063
CAUA113052069 113052070 113052072 113105799
PPRM120487640
MAMB125264591(alox12)
IPU108267744 108267745(alox12)
PHYP113539915
SMEO124387847 124387880 124388151
TFD113635137(alox12)
AMEX103037595
EEE113580793
TRU101070898
LCO104937156
NCC104948188
CGOB115023433
ELY117272669(alox12)
EFO125884070(alox12)
PLEP121962177(alox12)
SLUC116043997(alox12)
ECRA117934769(alox12)
ESP116707176
PFLV114545687
GAT120822087(alox12)
PPUG119222432(alox12)
MSAM119912247(alox12)
CUD121506630(alox12)
ALAT119026959(alox12)
MZE101479810
ONL100698983
OAU116321155(alox12)
OLA101174953
OML112155872(alox12)
XMA102224924
XCO114157899
XHE116733267
PRET103480141
PFOR103148853
PLAI106946955
PMEI106917266
GAF122820467(alox12)
CVG107103814
CTUL119775005(alox12)
GMU124880055(alox12)
NFU107384708(alox15)
KMR108242243(alox12)
ALIM106526983
NWH119414629(alox12)
AOCE111564179
MCEP125000804(alox12)
POV109637629
SSEN122766699(alox12)
HHIP117751994(alox12)
HSP118102186(alox12)
LCF108879679 108895226(alox12)
SDU111223569
SLAL111667993
XGL120797417(alox12)
BPEC110170766
MALB109957267
BSPL114849198(alox12)
SASA100380705(lox12) 106608934
STRU115194626 115198574
OTW112214522(alox12) 112259738
OMY110500350(alox12) 110531448
OGO124008639 124013533(alox12)
ONE115122959 115133313
SALP111952161
SNH120030395 120049296(alox12)
CCLU121554183 121571287(alox12)
ELS105027651
SFM108922837
PKI111846328
AANG118223344(alox12)
LOC102685586(alox12)
PSPA121305733 121306538
ARUT117426941
CMK103190915(alox12)
RTP109926716
MMER123540522
ATEN116304963
XEN124443531
 » show all
Reference
1  [PMID:4215079]
  Authors
Hamberg M, Samuelsson B.
  Title
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.
  Journal
Proc Natl Acad Sci U S A 71:3400-4 (1974)
DOI:10.1073/pnas.71.9.3400
Reference
2  [PMID:804329]
  Authors
Nugteren DH.
  Title
Arachidonate lipoxygenase in blood platelets.
  Journal
Biochim Biophys Acta 380:299-307 (1975)
DOI:10.1016/0005-2760(75)90016-8
Reference
3  [PMID:6783111]
  Authors
Wallach DP, Brown VR.
  Title
A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases.
  Journal
Biochim Biophys Acta 663:361-72 (1981)
DOI:10.1016/0005-2760(81)90165-X
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.31
IUBMB Enzyme Nomenclature: 1.13.11.31
ExPASy - ENZYME nomenclature database: 1.13.11.31
BRENDA, the Enzyme Database: 1.13.11.31
CAS: 82391-43-3

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