KEGG   ENZYME: 1.13.11.33
Entry
EC 1.13.11.33               Enzyme                                 
Name
arachidonate 15-lipoxygenase;
15-lipoxygenase;
linoleic acid omega6-lipoxygenase;
omega6 lipoxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 15-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [RN:R01593]
Reaction(KEGG)
R01593;
(other) R03626
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [CPD:C05966]
Comment
The product is rapidly reduced to the corresponding 15S-hydroxy compound.
History
EC 1.13.11.33 created 1984
Pathway
ec00590  Arachidonic acid metabolism
ec00591  Linoleic acid metabolism
ec01100  Metabolic pathways
Orthology
K00460  arachidonate 15-lipoxygenase
K08022  arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type)
K19246  arachidonate 15-lipoxygenase
Genes
HSA246(ALOX15) 247(ALOX15B)
PTR455104(ALOX15B) 748294(ALOX15) 750581
PPS100971127(ALOX15B) 100990568(ALOX15)
GGO101130490(ALOX15) 101138809 101141127(ALOX15B)
PON100174413(ALOX15) 100443582(ALOX15B)
NLE100598410(ALOX15) 100599862 115831495
MCC100425071 709212(ALOX15) 713683 716764(ALOX15B)
MCF102114788(ALOX15B) 102124513(ALOX15)
CSAB103242192(ALOX15) 103242262 103242336(ALOX15B)
CATY105581986(ALOX15B) 105583615(ALOX15) 105584566
PANU101012580 101014249(ALOX15) 101016522 101017215(ALOX15B)
TGE112609407(ALOX15B) 112609437(ALOX15) 112610174
RRO104661676(ALOX15B) 104673354 104677212(ALOX15)
RBB108514291(ALOX15B) 108514294 108520722(ALOX15)
TFN117067740(ALOX15B) 117067819 117067883(ALOX15)
PTEH111521361 111527063(ALOX15B)
CJC100388086(ALOX15) 100411880(ALOX15B)
SBQ101031385(ALOX15) 101048111(ALOX15B)
CSYR103253284(ALOX15) 103263441(ALOX15B)
MMUR105877322(ALOX15B) 105879207(ALOX15) 105879210
LCAT123621261(ALOX15) 123650917(ALOX15B)
OGA100953458(ALOX15) 100959028(ALOX15B)
MMU11687(Alox15) 11688(Alox8)
MCAL110305643 110306013(Alox15b)
MPAH110332116 110332396(Alox15b)
RNO266604(Alox15b) 81639(Alox15)
MCOC116077201(Alox15b)
MUN110541720 110541721 110542750 110551727(Alox15b)
CGE100754473(Alox15b) 100764916(Alox15)
MAUA101838120(Alox15b)
PLEU114693221 114693239(Alox15b) 114693249
MORG121456877(Alox15) 121456903(Alox15b)
AAMP119812940(Alox15) 119813001(Alox15b)
NGI103752102(Alox15b) 103752179(Alox15)
HGL101698545
CPOC100719677 100732272(Alox15b)
CCAN109693912(Alox15b) 109697448(Alox15)
DORD105983203 105983296 105983343 105983401(Alox15b)
DSP122100398 122100427(Alox15b) 122100448 122108619
NCAR124980374 124980592
OCU100009114(ALOX15) 100271999(ALOX12) 100342479(ALOX15B)
OPI101518498(ALOX15) 101525136(ALOX15B)
TUP102478167(ALOX15) 102488255 102494778 102495182(ALOX15B) 102495183
CFA119871841 489458(ALOX15) 489485(ALOX15B)
CLUD112647413(ALOX15B) 112647513(ALOX15)
VVP112924740(ALOX15B) 112924802(ALOX15) 112924804
VLG121500300(ALOX15B) 121500376
AML100475233(ALOX15B) 100479002(ALOX15)
UMR103660453(ALOX15) 103660486(ALOX15B)
UAH113271093(ALOX15) 113271172(ALOX15B)
UAR123792117(ALOX15B) 123792173(ALOX15)
ELK111161159 111161195
LLV125087857 125088107
MPUF101672354(ALOX15B) 101685628 101685913
ORO101379891 101380189(ALOX15) 101382890(ALOX15B)
EJU114225420(ALOX15B) 114225435 114225462
ZCA113907894(ALOX15B) 113908304
MLX117999900(ALOX15B) 117999977
FCA101101264(ALOX15B)
PYU121015961(ALOX15B)
PBG122484919(ALOX15B)
PTG102971044(ALOX15B)
PPAD109245909(ALOX15B)
AJU106972510(ALOX15B)
HHV120227740 120231436(ALOX15B)
BTA282139(ALOX15) 286820(ALOX15B)
BOM102275513(ALOX15B) 102281419 102285373 102285661(ALOX15)
BIU109574003 109574498
BBUB102396987 102397311(ALOX15) 102407045(ALOX15B)
CHX102169702 102178853 102179132
OAS101116587(ALOX15) 101121185
ODA120866022 120866092 120866093
CCAD122446170 122446330
SSC100525835 396971(ALOX15)
CFR102517336 102522465 116669221
CBAI105066404(ALOX15) 105077528(ALOX15B)
CDK105102997(ALOX15B) 105106001 116157868
VPC102528849(ALOX15B) 102544743(ALOX15)
BACU102998643(ALOX15B) 103006231(ALOX15)
LVE103073785(ALOX15) 103084519(ALOX15B)
OOR101281563(ALOX15) 101281720
DLE111185769 111185975(ALOX15)
PCAD102976974(ALOX15B) 102986457(ALOX15)
PSIU116745707(ALOX15) 116745711(ALOX15B)
ECB100072900(ALOX15) 100073039(ALOX15B)
EPZ103561432(ALOX15) 103564283(ALOX15B)
EAI106844159(ALOX15) 106844231(ALOX15B)
MYB102240358
MYD102765226 102769401
MMYO118672418(ALOX15)
MLF102421516 102421821 102427209 102427827 102433865 106694362
MNA107528023(ALOX15)
PKL118726749 118726750 118726751
HAI109394595(ALOX15) 109395112
DRO112308861(ALOX15)
SHON119001049(ALOX15)
AJM119043192(ALOX15)
PDIC114515339(ALOX15)
PHAS123809317(ALOX15)
MMF118634572(ALOX15)
RFQ117013821(ALOX15)
PALE102891969 102896986(ALOX15)
PGIG120607865(ALOX15)
PVP105291746(ALOX15)
RAY107509499(ALOX15)
MJV108383388(ALOX15B) 108386766(ALOX15)
TOD119231062 119231205 119232067 119232330
SARA101547759(ALOX15)
LAV100660599 100671025(ALOX15B) 104845446
TMU101354837 101355099 101359454
DNM101445760
MDO100015976(ALOX15)
GAS123247523
SHR100921165(ALOX15B)
PCW110194258
OAA100078105 100088503
CJO107307257
LSR110483683
PMOA120511271
PBI103058994
TSR106553882
VKO123016663
CCAR109045230
CAUA113038431
PPRM120462449 120474964 120476342 120477429 120478400 120479205 120480164
MAMB125244160 125244167 125246017 125246255 125261560 125261680 125263302 125265930 125265931 125268876
PHYP113541501
AMEX103026959 103036852 103039624 103039932 103042613 111196320 111197495
EEE113573261
LCO104934305
NCC104952601 104961663
CGOB115009844 115010916 115014711 115015183 115015193 115018543
ELY117254584 117254597 117254602 117254937 117254947 117255063 117255912 117266846(zgc:152891) 117271169
EFO125883499 125884274 125884311 125884329 125884340 125884350 125885404 125885405 125885406 125898661(zgc:152891)
PLEP121941966 121941967 121942039 121942559 121953099(zgc:152891)
SLUC116034395 116036443 116036660 116039739 116044067 116054988 116065866
ECRA117954393
PFLV114562807 114566285 114566432 114566433 114566434 114567140 114567161 114574044 114574045
GAT120808152 120809937
PPUG119227035
MSAM119895614(zgc:152891) 119898927 119914853
CUD121507916 121508342 121508343 121508538 121508638 121508696 121508734 121508827 121519044(zgc:152891)
ALAT119011326 119011392 119020453 119020471 119020488 119020499 119020523 119030911(zgc:152891)
MZE101479990 101480341
OAU120436295
OLA101159319 101161284 101162054 101162978 101163757 101165239 101165945 101172589 101174158 110014609 111947934
OML112137719 112137720 112138174 112138646(zgc:152891) 112141398 112141399 112141401 112157166 112157253
XMA102220792 102234026
XCO114145549 114153979
XHE116719544 116720456 116720772 116728488 116729360
PRET103459850 103461267 103461280 103467556
PFOR103129739 103136600 103148488 103148508 103153212
PLAI106950811 106951879 106951880 106951881 106960397 106964176
PMEI106906711 106909730 106909731 106917334 106922288 106925463
GAF122829020 122829021 122830234 122845455(zgc:152891)
CVG107082932 107095866 107104213
CTUL119773828 119781209(zgc:152891) 119794445 119794446 119794447
GMU124867860 124868793 124868811 124876399(zgc:152891) 124878254
NFU107375272
KMR108245609 108248081 108248088
NWH119408041 119420756(zgc:152891)
AOCE111570982
MCEP125003249 125003265 125021475(zgc:152891)
CSEM103383522
POV109638289
SSEN122760060 122770688 122779805(zgc:152891)
HHIP117762223 117764455 117765144
HSP118116182 118116190 118116197 124854466
SLAL111655595
BPEC110159844(alox12) 110162083 110165260 110165307 110165361 110174943 110175040 110175541
MALB109952244
BSPL114855575 114856233 114863291 114863312 114863328 114863344 114863360 114863402 114867365 114869596(zgc:152891)
OGO124020729 124020730 124020731 124020732 124022296 124022297 124027072
ONE115126421 115128059
SNH120034758 120034995 120034996 120035025 120035040 120035180 120040129 120040132 120040133 120040134
CCLU121556735 121556739 121556746 121564118
ELS105021020 105029901
SFM108934212
PKI111852905
LOC102693199 102697010
PSPA121297561 121303694 121319185
ARUT117404559 117427044 117967956 117968604
RTP109917782
BFO118414775 118414896 118426947 118429456
BBEL109467293 109467418 109471323 109488215
SKO100372903
HAME121878425
HRF124143004
CRG117692116
MMER123551204
OSN115215551
MGRMGG_08499
CFJCFIO01_03116
ELAUCREL1_55 UCREL1_9120
GLZGLAREA_07301
ZTRMYCGRDRAFT_12169
FCYFRACYDRAFT_236824
CLAPNCTC11466_02735(lox_2)
PGELG71_25915
MWIMNY66_07540
XBCELE36_00745
XBAC7S18_00355 C7S18_08820 C7S18_10525
PAEPA1169
PAEVN297_1207(lox)
PAEIN296_1207(lox)
PAUPA14_49300
PAPPSPA7_4211
PAGPLES_41521
PAFPAM18_3864
PNCNCGM2_2042
PAEBNCGM1900_1424
PDKPADK2_19800
PSGG655_19405
PRPM062_06360
PAEPPA1S_20055
PAERPA1R_gp4780
PAEMU769_19925
PAELT223_21220
PAESSCV20265_4254
PAEUBN889_01249
PAECM802_1203(lox)
PAEOM801_1207(lox)
SDNSden_1680
SWDSwoo_2318 Swoo_2919 Swoo_3415
SVOSVI_2441
SPSWSps_04756
SPSHFM037_05045
BLEPAL038_10310
NWANwat_1315
TBOGLT988_17945
KAKKalk_13355
GSNYC6258_04203
BTEBTH_I2353
BTQBTQ_1567(lox)
BTJBTJ_790(lox)
BTVBTHA_2232(lox)
BTHEBTN_2734(lox)
BTHMBTRA_2312(lox)
BTHLBG87_2254(lox)
KIAG8A07_12835
NEUNE1239(ALOX5)
NCOAAW31_14545
NMUNmul_A0532
AGEAA314_00836 AA314_01143
AVMJQX13_11260 JQX13_27420
MBDMEBOL_001824 MEBOL_002184
CFUSCYFUS_002292 CYFUS_005719
SCUSCE1572_24150 SCE1572_27890
SMAGAN936_17075
SMAZLH19_19595
STERAOA14_02395
SPHQBWQ93_18910
SPHXE5675_03520
SECHB18_17525
SPAPH3Z74_06555
CIJWG74_13295
SPHGAZE99_09630
SFLASPHFLASMR4Y_00458(lox)
SPHYCHN51_13340
PHAOHF685_12960
EMVHQR01_10545
NSRNS506_06256(loxA)
AMRAM1_0817 AM1_3564 AM1_3903
LEPLepto7376_1006
KOVK9N68_02125
LSCKIK02_06465
LSKJ5X98_00995
PSERABRG53_0246
MARMAE_42740
MVZmyaer102_17180
CYTcce_2648
CYPPCC8801_3106
CYHCyan8802_3014
MVAGD0A34_00765
OACOscil6304_2582
ONIOsc7112_5020
CEPCri9333_3532
NPUNpun_F6548 Npun_R0559
NOPNos7524_1960 Nos7524_4652
NONNOS3756_20330
NFLCOO91_02525 COO91_10101
NOECLI64_23140
NSHGXM_07187 GXM_07220
ANBANA_C20591
ACYAnacy_2339 Anacy_5241
AWAAA650_20325
CSGCylst_6054
RSINB6N60_00351
CALOCal7507_4394
CALTCal6303_3640
CALNNIES2098_25870
RIVRiv7116_3956 Riv7116_6077
NSPBMF81_03731(loxA)
NSPHBDGGKGIB_02222(lox)
DOUBMF77_01845(lox)
DFSHGD76_02925
AFLOHEQ12_20070
TOQHCG51_19130
FMRFuma_06255(lox)
GESVT84_11305(lox_1) VT84_28760(lox_2)
GMSSOIL9_39220
ULIETAA1_52760(lox)
 » show all
Reference
1  [PMID:6804460]
  Authors
Bryant RW, Bailey JM, Schewe T, Rapoport SM.
  Title
Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.
  Journal
J Biol Chem 257:6050-5 (1982)
Reference
2  [PMID:6813644]
  Authors
Narumiya S, Salmon JA.
  Title
Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes.
  Journal
Methods Enzymol 86:45-8 (1982)
DOI:10.1016/0076-6879(82)86166-1
Reference
3  [PMID:2496760]
  Authors
Oliw EH, Sprecher H.
  Title
Metabolism of polyunsaturated fatty acids by an (n - 6)-lipoxygenase associated with human ejaculates.
  Journal
Biochim Biophys Acta 1002:283-91 (1989)
DOI:10.1016/0005-2760(89)90342-1
Reference
4  [PMID:3112136]
  Authors
Shibata D, Steczko J, Dixon JE, Hermodson M, Yazdanparast R, Axelrod B.
  Title
Primary structure of soybean lipoxygenase-1.
  Journal
J Biol Chem 262:10080-5 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.33
IUBMB Enzyme Nomenclature: 1.13.11.33
ExPASy - ENZYME nomenclature database: 1.13.11.33
BRENDA, the Enzyme Database: 1.13.11.33
CAS: 82249-77-2

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