KEGG   ENZYME: 1.13.11.65
Entry
EC 1.13.11.65               Enzyme                                 
Name
carotenoid isomerooxygenase;
ninaB (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
zeaxanthin:oxygen 15,15'-oxidoreductase (bond-cleaving, cis-isomerizing)
Reaction(IUBMB)
zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal [RN:R10192]
Reaction(KEGG)
R10192
Substrate
zeaxanthin [CPD:C06098];
O2 [CPD:C00007]
Product
(3R)-11-cis-3-hydroxyretinal [CPD:C18195];
(3R)-all-trans-3-hydroxyretinal [CPD:C18196]
Comment
The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary caroteoids in insects. The enzyme accepts different all-trans carotenoids, including beta-carotene, alpha-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule.
History
EC 1.13.11.65 created 2012 as EC 1.14.13.164, transferred 2012 to EC 1.13.11.65
Orthology
K18048  carotenoid isomerooxygenase
Genes
BBEL109480034
DMEDmel_CG9347(ninaB)
DER6553504
DSE6606493
DSIDsimw501_GD18923(Dsim_GD18923)
DYADyak_GE26290
DAN6499668
DSR110191325
DPO4801297
DPE6587410
DMN108156831
DWI6651436
DGR6569858
DMODmoj_GI23158
DAZ108608798
DNV108660197
DHE111594412
DVI6635002
CCAT101460888
BOD106617378
RZE108378417
MDE101891299
SCAC106095816
LCQ111689802
LSQ119605303
HIS119650772
AGAAgaP_AGAP008143
ACOZ120958946
AARA120904890
ASTE118513706
AAG5577639
AALB109416057
CQUCpipJ_CPIJ001081
CPII120425068
CNS116347591
BCOO119068789
AME410521
ACER107998753
ALAB122711328
BIM100748194
BBIF117204884
BVK117243179
BVAN117155509
BTER100650576
BPYO122574794
CCAL108622230
OBB114874170
MGEN117226246
NMEA116427057
CGIG122400493
SOC105207446
MPHA105838552
AEC105152891
ACEP105627461
PBAR105429637
VEM105558153 105558802
HST105189528
DQU106742995 106743243
CFO105250638 105253782 109609955
FEX115240346
LHU105678748
PGC109851872
OBO105284924
PCF106786697
PFUC122526606
VPS122627968
NVI100121134
CSOL105366669
TPRE106651100
MDL103579989
CGLO123269454
FAS105270896
DAM107038456
AGIF122849754 122850321
LHT122504234
CCIN107271296
TCA655806
DPA109546877
SOY115889020
ATD109599337
CSET123306785
AGB108907741
LDC111509326
NVL108568592
APLN112904439
PPYR116158920 116158994 116159061
OTU111423088
BMOR101740058(ninaB-1)
BMAN114250535
MSEX115440616
DPLKGM_212590 KGM_212591 KGM_212592
BANY112048988 112048993 112048997
NIQ126771420 126771421 126771423 126771431
PMAC106711577 106711578
PPOT106106397 106106755
PXU106124795 106127765
PRAP111001438 111001440
ZCE119834455 119834491
HAW110384440
HZE124630116
TNL113497779
SLIU111348240
OFU114357399 114361325
PXY105388704
CFEL113370766
API100168974
DNX107165925
AGS114124246
RMD113553170
BTAB109031571
DCI103513261 103520924
CLEC106674446
HHAL106677578
NLU111044599
FOC113202254
TPAL117644107
ZNE110839939
CSEC111861717
FCD110854110
DPXDAPPUDRAFT_97232
DMK116920149
PVM113809949 113815366 113815367 113821294 113827985
PJA122243363 122245927 122247943 122262617 122262618
PCHN125043010 125044261 125044432
HAME121853934 121878637 121879857
PCLA123758838 123765072 123765221
PTRU123508703 123512187 123518893
HAZT108664736 108664738 108664739 108668518 108672094
EAF111704320
PPOI119093003 119093008
RSAN119394925 119395109
LGILOTGIDRAFT_153552
MMER123532876
 » show all
Reference
1  [PMID:19020100]
  Authors
Oberhauser V, Voolstra O, Bangert A, von Lintig J, Vogt K
  Title
NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide.
  Journal
Proc Natl Acad Sci U S A 105:19000-5 (2008)
DOI:10.1073/pnas.0807805105
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.65
IUBMB Enzyme Nomenclature: 1.13.11.65
ExPASy - ENZYME nomenclature database: 1.13.11.65
BRENDA, the Enzyme Database: 1.13.11.65

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