amnA (gene name);
amnB (gene name);
2-aminophenol:oxygen 1,6-oxidoreductase (decyclizing)
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
2-aminophenol:oxygen 1,6-oxidoreductase (ring-opening)
2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde [RN:
2-aminomuconate 6-semialdehyde [CPD:
The enzyme, a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent). The enzyme also has some activity with 2-amino-5-methylphenol and 2-amino-4-methylphenol . The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC
, 2-amino-5-chlorophenol 1,6-dioxygenase .
EC 126.96.36.199 created 2013
ec01120 Microbial metabolism in diverse environments
K15059 2-aminophenol/2-amino-5-chlorophenol 1,6-dioxygenase subunit beta
PKC: PKB_3263(amnb1) PKB_3611(amnb3) » show all
Takenaka S, Murakami S, Shinke R, Hatakeyama K, Yukawa H, Aoki K
Novel genes encoding 2-aminophenol 1,6-dioxygenase from Pseudomonas species AP-3 growing on 2-aminophenol and catalytic properties of the purified enzyme.
Wu JF, Sun CW, Jiang CY, Liu ZP, Liu SJ
A novel 2-aminophenol 1,6-dioxygenase involved in the degradation of p-chloronitrobenzene by Comamonas strain CNB-1: purification, properties, genetic cloning and expression in Escherichia coli.
Li de F, Zhang JY, Hou YJ, Liu L, Hu Y, Liu SJ, Wang da C, Liu W
Structures of aminophenol dioxygenase in complex with intermediate, product and inhibitor.