KEGG   ENZYME: 1.13.11.78
Entry
EC 1.13.11.78               Enzyme                                 
Name
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming);
phnZ (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming)
Reaction(IUBMB)
(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + phosphate [RN:R10722]
Reaction(KEGG)
R10722
Substrate
(2-amino-1-hydroxyethyl)phosphonate [CPD:C05678];
O2 [CPD:C00007]
Product
glycine [CPD:C00037];
phosphate [CPD:C00009]
Comment
Requires Fe2+. The enzyme, characterized from a marine bacterium, is involved in a 2-aminoethylphosphonate degradation pathway.
History
EC 1.13.11.78 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
K21196  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
Genes
BFO118428300
BBEL109475006
CIN101242664
SCLV120331588
SPU100894127
APLC110978365
SKO100376109
PVM113811511
EAF111702628
LGILOTGIDRAFT_172204
MYI110460342
PMAX117323924
OBI106870487
OSN115216972
LAK106156700
NVE116601128 5509073
EPA110244149
AMIL114975294
PDAM113683386
SPIS111325752
DGT114526236
QSU111995343
SSCKSPSK_02742 SPSK_09841
FVRFVEG_07744
MAWMAC_01243
MAJMAA_09260
CMTCCM_06455
PLJVFPFJ_04692 VFPFJ_10444
PSCOLY89DRAFT_642787
NFINFIA_065140
ANGANI_1_2760024(An02g08160)
PCSPc22g12750
TMFPMAA_015640
ZTRMYCGRDRAFT_104600 MYCGRDRAFT_96870
BCOMBAUCODRAFT_309643 BAUCODRAFT_37034
MRRMoror_5309
MBRMONBRDRAFT_9769
SREPTSG_05670
ACANACA1_131370 ACA1_196720
SMINv1.2.002470.t1(symbB.v1.2.002470.t1)
EHXEMIHUDRAFT_205428
PALCA0T30_00550
PPGPputGB1_5187
PPTPPS_4982
PPUHB479_25155
PPUNPP4_51980
PPUDDW66_5375
PMONX969_24605
PMOTX970_24240
PMOSO165_021700
PPJRK21_05378
PMOLCLJ08_11285
PFLPFL_5886
PPRCPFLCHA0_c58400
PPROPPC_5834
PFNHZ99_16105
PFOPfl01_5365
PFSPFLU_5807
PFCPflA506_5099
PPZH045_19430
PMANOU5_3801
PTVAA957_16045
PVRPverR02_29745
PAZOAYR47_05215
POIBOP93_24745
PRXHRH33_25590
PFWPF1751_v1c52220
PFFPFLUOLIPICF709865
PFXA7318_25715
PENPSEEN0270
PBAPSEBR_a22
PPUUPputUW4_05161
PSVPVLB_01395
PSKU771_30045
PCHEY04_31220
PCZPCL1606_03280
PCPJM49_01920
PFZAV641_01230
PSEMTO66_29740
PSECCCOS191_0283
PPSYAOC04_21410
PSOSPOS17_5830
PKRAYO71_01700
PFKPFAS1_12830
PANRA7J50_5534
PSILPMA3_28680
PYMAK972_0124
PKEDLD99_27310
PUMHGP31_29605
PPSHG5J76_04200
PGYAWU82_08025
PATAJWU58_02255
PZEHU754_028605
PMOEHV782_027640
PSEPC4K39_3779
PVWHU752_030920
PTRTHU722_0028015
PXAKSS93_00650
PSAMHU731_014145
PTZHU718_028860
PSHHHU773_026560
PXNHU772_023530
PANHHU763_023215
PFAKKSS94_01295
PMAMKSS90_01415
PAZEKSS91_27370
PORYEJA05_26835
PTKEXN22_02675
PIEHU724_026755
PWYHU734_001945
PGFJ0G10_29195
PCAVD3880_01205
PIZLAB08_R57530
PPEGKUA23_28405
PSIINF676_25710
PSIHLOY51_25660
PXIJ5O05_16035
ALGAQULUS_23780
LHALHA_1529
LCDclem_07260
LLG44548918_01854
LCJNCTC11976_01455
FHACDV26_02630
NCUF0U83_10385
CVICV_1839
CVCBKX93_22430
CHROCXB49_13150
CHRIDK842_16370
CHRBDK843_21895
GMRGmarT_03180
CPICpin_2968
CHFKTO58_21985
NKONiako_2712
PSEGD3H65_26340
PGINFRZ67_07390
FLCKJS93_18225
FLVKJS94_02230
SEDTTEGAF0_09290
PCMAY601_2093
PMUOLOK61_14625
MUPA0256_23040
MUCMuYL_1124
MGOTMgSA37_00812
MUHHYN43_027925
MGINFRZ54_02780
MGKFSB76_24850
MRUBDEO27_029700
MGOSDIU38_031875
CMRCycma_1724
CAMUCA2015_1630
SLISlin_3397
SRDSD10_19030
SMONAWR27_04710
SPIRCWM47_32850
SPIKEXU85_08700
SPIBG8759_17555
STAEHNV11_07495
SRHOHH216_12685
CHRWKA713_08260
RHOZGXP67_25885
RSIRunsl_4009
RUNDR864_01355
RUPDTQ70_11150
EOLEmtol_0956
FAEFAES_5432
FIBA6C57_02290
ALSDJ013_20145
MAQALAG90_14980
HYZAXW84_22205
HNVDDQ68_03200
CHKD4L85_03505
 » show all
Reference
1  [PMID:22564006]
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J Am Chem Soc 134:8364-7 (2012)
DOI:10.1021/ja302072f
Reference
2  [PMID:24198335]
  Authors
Worsdorfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME
  Title
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases.
  Journal
Proc Natl Acad Sci U S A 110:18874-9 (2013)
DOI:10.1073/pnas.1315927110
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.78
IUBMB Enzyme Nomenclature: 1.13.11.78
ExPASy - ENZYME nomenclature database: 1.13.11.78
BRENDA, the Enzyme Database: 1.13.11.78

DBGET integrated database retrieval system