KEGG   ENZYME: 1.13.11.9
Entry
EC 1.13.11.9                Enzyme                                 
Name
2,5-dihydroxypyridine 5,6-dioxygenase;
2,5-dihydroxypyridine oxygenase;
pyridine-2,5-diol dioxygenase;
NicX
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
Reaction(IUBMB)
2,5-dihydroxypyridine + O2 = N-formylmaleamic acid [RN:R09125]
Reaction(KEGG)
R09125
Substrate
2,5-dihydroxypyridine [CPD:C01059];
O2 [CPD:C00007]
Product
N-formylmaleamic acid [CPD:C18232]
Comment
Requires Fe2+.
History
EC 1.13.11.9 created 1965 as EC 1.13.1.9, transferred 1972 to EC 1.13.11.9, modified 2010
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18028  2,5-dihydroxypyridine 5,6-dioxygenase
Genes
SMARSM39_1771
SMACSMDB11_1584
SMWSMWW4_v1c23260
SPESpro_2312
SRRSerAS9_2269
SRLSOD_c21420(nicX)
SRYM621_11735
SPLYQ5A_011870(nicX)
SRSSerAS12_2269
SRASerAS13_2270
SLQM495_11505
SERFL085_17115
SQUE4343_04630
SFJSAMEA4384070_2381
SOFNCTC11214_04488
SURIJ0X03_12365
GQUAWC35_02975
PAOPat9b_5175
TCIA7K98_12095
TPTYNCTC11468_02202
PPUPP_3945(nicX)
PPFPput_1892
PPGPputGB1_3580
PPWPputW619_2138
PPTPPS_4058
PPBPPUBIRD1_1863
PPIYSA_08963
PPXT1E_5122
PPUTL483_21715
PPUNPP4_17770
PFSPFLU_2800
PFBVO64_0127
PAZOAYR47_21620
PMEDE3Z27_20705
PFWPF1751_v1c24710
PFFPFLUOLIPICF724375
PFXA7318_11825
PLULFOB45_03920
PSKU771_14860
PFZAV641_08730
PANRA7J50_2717
PSILPMA3_12570
PYMAK972_2676
PGGFX982_03129
PVKEPZ47_21845
PEZHWQ56_12835
PWYHU734_022660
PTAENCTC10697_01684
PPEGKUA23_13470
AWUBEN71_18360
AGUAS4_40080
HAMHALO0548
HVNEI420_02005
HOLHORIV_64960
HAXIHAALTHF_14370n
HTTHZS52_07580
HSVHNO53_05730
HTXEKK97_06015
HPROLMS44_20650
ADIB5T_02297
MARSA8C75_16295
RPJN234_04330 N234_15835 N234_24890
REHH16_A0925(h16_A0925) H16_A2810(h16_A2810) H16_B0813(h16_B0813)
CNCCNE_1c08750 CNE_1c27100 CNE_2c07610
CUHBJN34_04910 BJN34_15135 BJN34_29420
REUReut_A2512 Reut_B3788
CTIRALTA_A0870 RALTA_A2299
CBWRR42_m3126 RR42_s0171 RR42_s1172
CGDCR3_0579(ampS) CR3_0803(ampS) CR3_3007(nicX)
CCUPBKK81_07370 BKK81_15650
CUPBKK80_06670 BKK80_16605
CUUBKK79_05480 BKK79_16350
CPAUEHF44_27015
COXE0W60_08960 E0W60_14770 E0W60_23265
CCAMM5D45_06905
BSAVWS86_30280
BCMBcenmc03_3486
BCHBcen2424_4039
BCJBCAM1142
BCENDM39_3879
BCEOI35_4989
BMJBMULJ_03960
BMUBmul_4550
BMKDM80_3720
BMULNP80_4069
BCEDDM42_3948
BCONNL30_06920
BSEMWJ12_25610
BPSLWS57_08415
BMECWJ16_24240
BSTGWT74_20825
BANNJFN94_22955 JFN94_25175
BGDbgla_1g12670
BGOBM43_2599
BYIBYI23_D006280 BYI23_D011200
BUEBRPE67_DCDS08100 BRPE67_DCDS13330
BGPBGL_1c11600
BPLAbpln_1g11120
BUMAXG89_36965
BUIAX768_15625
BURKDM992_20105
BXEBxe_C0216
BXBDR64_8215
BFNOI25_6799
BCAIK788_0007381
PTERC2L65_30585
PTROG5S35_31885
PPKU875_06205
PPNODA70_23280
PPNMLV28_07430
PRBX636_03370
PPULRO07_01615
PSPUNA29_10040 NA29_11640 NA29_13055
PAPISG18_01755
PVEUC34_12640 UC34_17850
POXMB84_21140 MB84_22640
PTXABW99_20545
PFGAB870_04880
PNRAT302_14240 AT302_20395
PANDDRB87_16370
PFIBPI93_010200
PCOMNTU39_19585
CABASBC2_37490(nicX_1) SBC2_53530(nicX_2)
BUOBRPE64_DCDS05940 BRPE64_DCDS10990
BPEBP0581 BP1957
BPCBPTD_0590 BPTD_1929
BPERBN118_0957 BN118_3486
BPETB1917_3473
BPEUQ425_15030 Q425_35680
BPARBN117_0269 BN117_1484
BPABPP0271 BPP2330
BBHBN112_1734 BN112_3143
BBRBB0274 BB1781
BBMBN115_0259 BN115_1683
BBXBBS798_0269 BBS798_1682
BAVBAV1529 BAV2742
BBROBAU06_10300 BAU06_12295 BAU06_25035
BFZBAU07_14190 BAU07_23450 BAU07_25070
BPDZBBN53_17720
BOHAKI39_11515
BGMCAL15_11470 CAL15_12490
AXYAXYL_02466
AXONH44784_051911
AXNAX27061_3327
AXXERS451415_03307
ADTAPT56_16400
AISBUW96_02610 BUW96_28750
ASWCVS48_09645
ACHRC2U31_23370
ACHBDVB37_25110
PUDG9Q38_03255 G9Q38_04180 G9Q38_04670
AKATKWG_00615 TKWG_01105 TKWG_19790
AMIMMIM_c02050 MIM_c31080
AFAUZ73_03775 UZ73_10785 UZ73_14565 UZ73_14765
AFQAFA_13575 AFA_14965(nicX) AFA_15135(picD) AFA_18565(hpaX)
AAQUD3M96_14525 D3M96_15895 D3M96_16075
AAMMFE795_12525 FE795_13825 FE795_14000
PHNPAEH1_03580
ODIODI_R3898
PIGEGT29_00800 EGT29_02745 EGT29_03390
PACRFXN63_06615
RHFEUB48_20920
AAVAave_3930
AAAAcav_3827
ACKC380_17105
DACDaci_1850
DELDelCs14_4788
DTSBI380_15400
DHKBO996_08760
DLAI6G47_15030
VAPVapar_4293
VAMC4F17_28025
CTESO987_23190
LIML103DPR2_00582(nicX)
LIHL63ED372_00060(nicX)
HYBQ5W_22175
HYLLPB072_00950
HYCE5678_16815
HPSEHPF_00905(nicX)
HYNF9K07_01290 F9K07_02925 F9K07_21765
HTNKI616_00800
HCZG9Q37_17660
HSEHsero_1325
HSZACP92_06630
HEEhmeg3_19265
HFRG5S34_06840
MTIMDIR46_21155
XYKGT347_17965
AZRCJ010_02410 CJ010_22080
MLNA9174_33965
MAMOA6B35_09700
MESPC1M53_21410
MESRFGU64_17615
HOEIMCC20628_03533
AAKAA2016_6001 AA2016_6584
SIXBSY16_4976
ATAAWN88_01320
RLGRleg_6046
RTRRTCIAT899_PC08580
RADCO657_35880
RIIFFM53_028515
RRGJ3P73_36855
RAWNE851_01760
RSULN2599_21415
SHZshn_30285
OCHCES85_3503(nicX)
BJAbll6088(bll6088)
BJUBJ6T_36210
BJPRN69_17555
BRABRADO2312
BRSS23_21870
AOLS58_52840
BRCBCCGELA001_25855
BRADBF49_5545
BROBRAD285_5030
BRKCWS35_28865
BOTCIT37_06750 CIT37_23840
BRQCIT40_22420
BGQX265_12340 X265_13550
BGZXH91_11115
BSYMCIT39_21615
BBETF8237_26010
BARHWN72_34005 WN72_44280
BVZBRAD3257_3041
BELBE61_17030
BDGLPJ38_32260
BQBJ4P68_0007725
BSEIKMZ68_19940
RBKE0H22_02850 E0H22_16390
TRBHB776_11430
HMCHYPMC_0203
RHZRHPLAN_69100
NTDEGO55_05275
PHLKKY_3788
PLEOOHA_1_03169(nicX)
HDIHDIA_0234(nicX)
AUBLXB15_07185
PSINCAK95_12375 CAK95_14180 CAK95_27070
PPHRAPZ00_25430
SIWGH266_12020
OAROA238_c08170
CIDP73_3892
CEHCEW89_08860
CONTQ29_12570 TQ29_12770 TQ29_16070
PABYGa0080574_TMP31
SAGUCDO87_22440
MALUKU6B_06560
PYEA6J80_00020 A6J80_23200
DAAAKL17_3241
LVSLOKVESSMR4R_03232(nicX)
PALWPSAL_024210(nicX)
FAPGR316_10985
GCEKYE46_03215
NSMJO391_01895
SNJA7E77_04545
SMYBJP26_14900
SBARH5V43_21650(ndpE)
ELQGa0102493_111595
GOYGLS_c14230
GALA0U94_10315
GTIFXF46_02575
GSPIGS75_12410
GXLH845_1042
KEUS101446_01672(nicX)
KSCCD178_02878(nicX)
KREGWK63_12515
APTAPA01_23760
APWAPA42C_23760
APFAPA03_23760
APUAPA07_23760
APGAPA12_23760
APQAPA22_23760
APXAPA26_23760
APZAPA32_23760
APKAPA386B_1210
ASVWG31_11905
APOMCPF11_08775
ATOCIW82_09425
AASCA4S02_13830
ACETDS739_11635
ROSCTJ15_00290
RMUCFOB66_01435
KHAIFJ82_11095
SRFLHU95_20255
ALIAZOLI_p20433
ABSAZOBR_p480011
ABQABAZ39_30180
ABFAMK58_25905
ATIAL072_30665
AZTTSH58p_19530
AZMDM194_20100 DM194_21870
AOZHUE56_08300
HTQFRZ44_18690
HADHFRZ61_39250 FRZ61_46310
APBSAR116_0287
BACAFAY30_11695
PARHI5S86_12070
MVQMYVA_3797
ROAPd630_LPD07329
RFAA3L23_03312(nicX)
RHSA3Q41_00020(nicX)
RCRNCTC10994_03415
SVLStrvi_4768
SRCM271_44585
SMALSMALA_0613
SSOII1A49_06645
SALUDC74_1449
SALLSAZ_07780
STREGZL_07763
SNRSNOUR_35470
SAUOBV401_06895
SBATG4Z16_06625
SINEKI385_04355
SDURM4V62_06910
JMEEEW87_000025
SAIUJ4H86_13115
FALFRAAL6169
AOIAORI_4776
AJAAJAP_15760(nicX)
AMQAMETH_3951
AMYCCU254_15755
AMYYYIM_29130(nicX)
AACDLWP59_17615
AROONQK81_43040
PSEAWY02_22100
PSEEFRP1_20590
PSEHXF36_05315
PSEQAD006_28010
PECQAD017_07605
PHHAFB00_17850
PAUTPdca_13590
PBROHOP40_05480
PSUUPsuf_015390
SBAEDSM104329_02297(nicX_1) DSM104329_02308(nicX_2) DSM104329_02367(nicX_3) DSM104329_02480(nicX_4) DSM104329_03697(nicX_5) DSM104329_03708(nicX_6)
HAADMW046_15080
HLSKU306_03805
SRUBC2R22_21800
MJNMjAS7_2157
 » show all
Reference
1  [PMID:13475371]
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
2  [PMID:5578917]
  Authors
Gauthier JJ, Rittenberg SC
  Title
The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9.
  Journal
J Biol Chem 246:3737-42 (1971)
  Sequence
[ppu:PP_3945]
Reference
3  [PMID:5578918]
  Authors
Gauthier JJ, Rittenberg SC.
  Title
The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation.
  Journal
J Biol Chem 246:3743-8 (1971)
  Sequence
[ppu:PP_3945]
Reference
4  [PMID:18678916]
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.
  Journal
Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105
  Sequence
[ppu:PP_3945]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.9
IUBMB Enzyme Nomenclature: 1.13.11.9
ExPASy - ENZYME nomenclature database: 1.13.11.9
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.9
BRENDA, the Enzyme Database: 1.13.11.9
CAS: 9029-57-6

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