KEGG   ENZYME: 1.14.11.46
Entry
EC 1.14.11.46               Enzyme                                 
Name
2-aminoethylphosphonate dioxygenase;
phnY (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
(2-aminoethyl)phosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)
Reaction(IUBMB)
(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2 [RN:R10724]
Reaction(KEGG)
R10724
Substrate
(2-aminoethyl)phosphonate [CPD:C03557];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(2-amino-1-hydroxyethyl)phosphonate [CPD:C05678];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate. The enzyme, characterized from an uncultured marine bacterium, is involved in a (2-aminoethyl)phosphonate degradation pathway.
History
EC 1.14.11.46 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
Orthology
K21195  2-aminoethylphosphonate dioxygenase
Genes
QSU111983342 112009534 112031218
SSCKSPSK_09539
FVRFVEG_07745
FOXFOXG_04606
MAWMAC_01242
MAJMAA_09259
PLJVFPFJ_04691 VFPFJ_10443
BFUBCIN_06g00110
PSCOLY89DRAFT_740562 LY89DRAFT_780538
NFINFIA_065130
AORAO090003000788
ANGANI_1_1162024(An02g08170)
AFVAFLA_000896
ALUCAKAW2_10681S
ACHEACHE_70898S
APUUAPUU_10043A APUU_21506A APUU_22170A
PCSPc18g03420 Pc22g12760
TMFPMAA_082580
TRGTRUGW13939_10951
PFJMYCFIDRAFT_208708
FFUCLAFUR5_08687
BCOMBAUCODRAFT_150689 BAUCODRAFT_152254
TASAA1Q1_05374
MPRMPER_04257 MPER_08557 MPER_09847
MRRMoror_5305
MOREE1B28_010180
ACANACA1_254860
PTIPHATRDRAFT_45928
FCYFRACYDRAFT_268105
EHXEMIHUDRAFT_205428
SRLSOD_c30110
SRYM621_16415
XVAC7V42_21005
PPZH045_01945
LHALHA_1528
LCDclem_07265 clem_12590
LLG44548918_01853
LCJNCTC11976_01454
FHACDV26_02635
NOCNoc_1391
NHLNhal_1353
NWANwat_1690
NJPNEJAP_2516
BOKDM82_2522
BOCBG90_2211
BSAVWS86_03975
BPLAbpln_2g04930
BCAIK788_00002425
CPRACPter91_0286
MLOmlr5924
MLNA9174_32400
MAMOA6B35_30635
MJREB229_33120
MERDEB233_30770
MOHIHQ72_34060
ARAArad_7878
RECRHECIAT_PB0000354
REPIE4803_PB00468
RHNAMJ98_PC00366
RPHAAMC79_PC00337
RHXAMK02_PC00355
RHKKim5_PA00463
REZAMJ99_PB00360
BJAblr2133(blr2133)
BJUBJ6T_77170
BJPRN69_37475
BRCBCCGELA001_30190
SXAFMM02_04075
RGIRGI145_09800
ROSCTJ15_07630
RMUCFOB66_09655
LCKHN018_01530
HTQFRZ44_48830
HADHFRZ61_47170
ECOGFIV45_14930
PSWUSY83_09970
MMAMK3U93_12405
SLIAHA039_16970
NPSKRR39_01800
FRAFrancci3_1994
ABAIIMCC26256_11466
AYMYM304_40490
AQZKSP35_12360
SYNDKR52_11175
PMFP9303_11261
PMGP9301_12551
TOQHCG51_21855
NCNBZZ01_05245
SNGSNE_A16380
PIRVN12_13835
LCREPla8534_05960
PLSVT03_21420
GPNPan110_03670
LRSPX52LOC_01454
TSPHKIH39_09740 KIH39_13710
PGOFSB84_15750
PCMAY601_0443
 » show all
Reference
1  [PMID:22564006]
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J Am Chem Soc 134:8364-7 (2012)
DOI:10.1021/ja302072f
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.46
IUBMB Enzyme Nomenclature: 1.14.11.46
ExPASy - ENZYME nomenclature database: 1.14.11.46
BRENDA, the Enzyme Database: 1.14.11.46

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