KEGG   ENZYME: 1.14.11.68
Entry
EC 1.14.11.68               Enzyme                                 

Name
[histone H3]-trimethyl-L-lysine27 demethylase;
KDM6A (gene name);
KDM6C (gene name);
UTX (gene name);
UTY (gene name);
JMJD3 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[histone H3]-N6,N6,N6-trimethyl-L-lysine27,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R12459];
(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2 [RN:R12460];
(1b) a [histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2 [RN:R09510]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6,N6-trimethyl-L-lysine27;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6,N6-dimethyl-L-lysine27
Product
[histone H3]-N6-methyl-L-lysine27;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6,N6-dimethyl-L-lysine27
Comment
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.
History
EC 1.14.11.68 created 2019
Orthology
K11447  lysine-specific demethylase 6A
K11448  lysine-specific demethylase 6B
K23742  lysine-specific demethylase 6C
Genes
HSA: 23135(KDM6B) 7403(KDM6A) 7404(UTY)
PTR: 112204057 449579(UTY) 465593(KDM6A) 468438(KDM6B)
PPS: 100971965(KDM6B) 100981353(KDM6A)
GGO: 101145831(KDM6A) 101146851(KDM6B)
PON: 100440779(KDM6B) 100455632(KDM6A)
NLE: 100581756(KDM6B) 100592229(KDM6A)
MCC: 100270704(UTY) 100427119(KDM6A) 716348(KDM6B)
MCF: 102122893(KDM6A) 102138681(KDM6B)
CSAB: 103231851(KDM6A) 103242325(KDM6B) 103246976(UTY)
CATY: 105582140(KDM6B) 105590543(KDM6A)
PANU: 101004686(KDM6A) 101010194(KDM6B) 116272355
RRO: 104657060(UTY) 104661704(KDM6B) 104681961(KDM6A)
RBB: 108514285(KDM6B)
TFN: 117067744(KDM6B) 117078283(KDM6A)
PTEH: 111527087(KDM6B) 111535634 111536376(KDM6A)
CJC: 100405718(KDM6A) 100414637(KDM6B)
SBQ: 101030793(KDM6A) 101031578(KDM6B)
MMUR: 105865482(KDM6A) 105877396(KDM6B)
MMU: 216850(Kdm6b) 22289(Kdm6a) 22290(Uty)
MCAL: 110286985(Kdm6a) 110304445(Kdm6b)
MPAH: 110313380(Kdm6a) 110331384(Kdm6b)
RNO: 100310845(Uty) 103689969(Kdm6a) 363630(Kdm6b)
MCOC: 116072103(Kdm6a) 116077735(Kdm6b) 116096502
MUN: 110542546 110555144(Kdm6b)
CGE: 100758834(Kdm6a)
PLEU: 114680956(Kdm6a) 114693164(Kdm6b)
NGI: 103731790(Kdm6a) 103752113(Kdm6b)
HGL: 101703654(Kdm6b) 101706268(Kdm6a)
CCAN: 109680035 109683662(Kdm6a) 109693893(Kdm6b)
OCU: 100343083(KDM6B) 100347603(KDM6A)
OPI: 101524486(KDM6A) 101535492(KDM6B)
TUP: 102482383(KDM6B) 102487244(KDM6A) 102494740
CFA: 489481(KDM6B) 491845(KDM6A)
VVP: 112911969 112924857(KDM6B) 112930002(KDM6A)
VLG: 121483572(KDM6A) 121499575(KDM6B)
AML: 100476598(KDM6A) 100477084(KDM6B)
UMR: 103660480(KDM6B) 103666195(KDM6A) 103680203
UAH: 113248376 113265907(KDM6A) 113271139(KDM6B)
MPUF: 101670258(KDM6B) 101675513(KDM6A)
EJU: 114216709(KDM6A) 114225289(KDM6B)
MLX: 118000038(KDM6B) 118009451(KDM6A) 118009497
FCA: 101088307(KDM6A) 101100010(KDM6B)
PYU: 121015749(KDM6B) 121024775 121026124(KDM6A)
PBG: 122477307(KDM6A) 122484907(KDM6B)
PTG: 102955246 102962926(KDM6A)
PPAD: 109246086(KDM6B) 109248052(KDM6A)
AJU: 106972505(KDM6B) 106972538(KDM6A) 106985056
HHV: 120231475(KDM6B) 120245058(KDM6A)
BTA: 100140276(KDM6B) 280952(KDM6A)
BOM: 102273800(KDM6B) 102274742(KDM6A)
BIU: 109555184(KDM6A) 109555600 109573750(KDM6B)
BBUB: 102395023(KDM6B) 102400345(KDM6A)
CHX: 102168575(KDM6B) 102191597(KDM6A) 108634619
OAS: 101103543(KDM6A) 101119656(KDM6B)
ODA: 120860170 120866030(KDM6B) 120882233(KDM6A)
CCAD: 122434312 122435115(KDM6A) 122445677(KDM6B)
SSC: 100154376(KDM6A) 100512495(KDM6B) 110255320
CFR: 102523561(KDM6B) 102523633(KDM6A)
CBAI: 105077581(KDM6B) 105079353(KDM6A)
CDK: 105085270(KDM6A) 105103070(KDM6B)
BACU: 103003878(KDM6A) 103016921(KDM6B)
LVE: 103073128(KDM6A) 103083949(KDM6B)
OOR: 101269349(KDM6A) 101284645(KDM6B)
DLE: 111165558(KDM6A) 111185695(KDM6B)
PCAD: 102976704(KDM6B) 102983773(KDM6A)
ECB: 100059800(KDM6A) 100073033(KDM6B)
EAI: 106825057 106827448(KDM6A) 106844144(KDM6B)
MYB: 102241356(KDM6A) 102242922(KDM6B) 102260650
MYD: 102756321(KDM6A) 102767919(UTY) 102775429(KDM6B)
MMYO: 118653897(KDM6A) 118660160 118672088(KDM6B)
MNA: 107533023 107541456(KDM6A) 107544494(KDM6B)
HAI: 109386479(KDM6A) 109395116(KDM6B)
DRO: 112306833 112308749(KDM6B) 112322497(KDM6A)
SHON: 118974713(KDM6B) 118981094(KDM6A) 119000751
AJM: 119041661(KDM6A) 119053531(KDM6B)
MMF: 118616759 118633878(KDM6B) 118635629(KDM6A)
PALE: 102882574(KDM6A) 102891492(KDM6B) 102897701
PGIG: 120586015 120589682(KDM6B) 120593674(KDM6A)
RAY: 107502042 107515683(KDM6B) 107521705(KDM6A)
MJV: 108383384(KDM6B) 108391267(KDM6A)
TOD: 119230736(KDM6B) 119246208(KDM6A) 119250803
LAV: 100669039(KDM6A) 100669880(KDM6B)
MDO: 100016846(KDM6A)
SHR: 100914132(KDM6B) 100931212(KDM6A)
PCW: 110194281(KDM6B) 110214916(KDM6A)
OAA: 100081798(KDM6A) 103167751(KDM6B)
GGA: 418556(KDM6A)
PCOC: 116229864(KDM6A)
CJO: 107324231(KDM6A)
NMEL: 110403634(KDM6A)
APLA: 101792422(KDM6A)
ACYG: 106036049(KDM6A)
TGU: 100231869(KDM6A) 115492722
LSR: 110474877(KDM6A) 110481217(KDM6B)
SCAN: 103815764(KDM6A)
PMOA: 120509526 120511895(KDM6A)
OTC: 121333524(KDM6A)
PRUF: 121364540(KDM6A)
GFR: 102034141(KDM6A)
FAB: 101814502(KDM6A)
PHI: 102100209(KDM6B) 102104710(KDM6A)
PMAJ: 107202288(KDM6A)
CCAE: 111927175(KDM6A)
CCW: 104686240(KDM6A)
ETL: 114055736(KDM6A)
FPG: 101910985(KDM6A)
FCH: 102055770(KDM6A)
CLV: 102086584(KDM6A)
EGZ: 104133576(KDM6A)
NNI: 104020856(KDM6A)
ACUN: 113483873(KDM6A)
PADL: 103912591(KDM6A)
AAM: 106483685(KDM6A)
AROW: 112970743(KDM6A)
NPD: 112944704(KDM6A) 112957730
DNE: 112981970(KDM6A)
ASN: 102375331(KDM6A) 102378019(KDM6B)
AMJ: 102565918(KDM6B) 102573879(KDM6A)
CPOO: 109305891(KDM6A)
GGN: 109302564(KDM6A)
PSS: 102452800(KDM6B) 102457422(KDM6A)
CMY: 102935096(KDM6A) 102947171(KDM6B)
CPIC: 101934912(KDM6A) 101935571(KDM6B)
TST: 117868189(KDM6A)
CABI: 116836973 116839643(KDM6B)
ACS: 100561474(kdm6b) 100564779(kdm6a)
PVT: 110074058(KDM6A) 110087745(KDM6B)
PMUR: 107286489 107299463(KDM6B)
TSR: 106548216 106551474(KDM6A) 106552123(KDM6B)
PGUT: 117669433(KDM6A) 117671253(KDM6B)
PMUA: 114582422(KDM6B) 114596145(KDM6A)
ZVI: 118084846(KDM6A) 118094254(KDM6B)
GJA: 107109235(KDM6A) 107119809(KDM6B)
XLA: 108703539(kdm6b.S) 108708200 108711772(kdm6b.L) 446609(kdm6a.S)
XTR: 100170558(kdm6a) 779446(kdm6b)
NPR: 108794712(KDM6A) 108794738(KDM6B)
DRE: 556678(kdm6ba) 563644(kdm6bb) 569207(kdm6al) 569277(kdm6a)
PHYP: 113524185 113524844(kdm6a) 113540439(kdm6b) 113545870
AMEX: 103021707 103025477(kdm6a) 103028490 103028970(kdm6b)
NCC: 104942379 104954641(kdm6a) 104964153(kdm6b)
ELY: 117246505(kdm6ba) 117247136 117249797(kdm6a) 117250080
PLEP: 121948731(kdm6a) 121952575 121961826(kdm6ba) 121962859
SLUC: 116042290(kdm6ba) 116044629 116047057(kdm6a) 116064771(kdm6bb)
ECRA: 117934927(kdm6ba) 117939341 117953083(kdm6a) 117956101(kdm6bb)
PFLV: 114546182(kdm6b) 114551161 114564534(kdm6a) 114566359
GAT: 120821599 120821718(kdm6ba) 120825076 120834389(kdm6a)
PPUG: 119209894 119215193 119223326(kdm6ba) 119228459(kdm6a)
MSAM: 119895078(kdm6bb) 119902297 119904594(kdm6a) 119911581(kdm6ba)
CUD: 121504442(kdm6ba) 121506191 121519233(kdm6bb) 121522394(kdm6a)
OAU: 116311192(kdm6a) 116328877 116329126(kdm6bb) 116329922(kdm6ba)
OML: 112142481(kdm6bb) 112154991(kdm6a) 112156329(kdm6ba) 112160186
PRET: 103475798 103475867 103480559(kdm6b) 103481677(kdm6a)
CTUL: 119772681 119779467(kdm6ba) 119782260 119788067(kdm6bb)
NFU: 107376882(kdm6b) 107381076(kdm6a) 107386615
KMR: 108233868(kdm6bb) 108242869(kdm6ba) 108243541(kdm6a) 108249342
AOCE: 111563862(kdm6a) 111571569(kdm6b) 111571985 111575440
CSEM: 103389705 103391115(kdm6b) 103391558(kdm6a) 103394748
XGL: 120797597(kdm6ba) 120798292 120801186(kdm6a) 120803024(kdm6bb)
MALB: 109952094(kdm6a) 109960405 109971923(kdm6b) 109973222
AANG: 118213586(kdm6a) 118224327 118236600(kdm6ba)
LOC: 102686522(kdm6b) 102692642(kdm6a)
LCM: 102350275(KDM6A) 102354908(KDM6B)
CMK: 103183921(kdm6a)
RTP: 109919147(kdm6a) 109924747(kdm6b)
BFO: 118426912
BBEL: 109485731
CIN: 100185843
SCLV: 120348129
SPU: 587845
APLC: 110981656
SKO: 100366814
DME: Dmel_CG5640(Utx)
DER: 6541075
DSE: 6611949
DSI: Dsimw501_GD22282(Dsim_GD22282)
DAN: 6496950
DSR: 110183393
DPE: 6588710
DMN: 108161316
DWI: 6653350
DGR: 6567004
DNV: 108649669
DHE: 111594733
DVI: 6627378
CCAT: 101455787
BOD: 106627151
MDE: 101888100
SCAC: 106092698
LCQ: 111684696
ACOZ: 120956422
AARA: 120902251
AAG: 5577734
CPII: 120419662
AME: 412863
ACER: 107993000
BIM: 100740862
BBIF: 117209499
BVK: 117233677
BVAN: 117158626
BTER: 100646833
CCAL: 108626073
OBB: 114874915
MGEN: 117228047
NMEA: 116426346
CGIG: 122401153
SOC: 105208158
MPHA: 105831887
AEC: 105145441
ACEP: 105621895
PBAR: 105425233
VEM: 105566126
HST: 105185449
DQU: 106740982
FEX: 115242548
LHU: 105672366
PGC: 109856462
OBO: 105279865
PCF: 106787937
NVI: 100120693
CSOL: 105368386
TPRE: 106651610
MDL: 103569314
FAS: 105267080
DAM: 107039261
CCIN: 107274793
TCA: 657074
DPA: 109532897
ATD: 109602948
AGB: 108909357
LDC: 111518305
NVL: 108562582
APLN: 108742315
PPYR: 116165255
OTU: 111425148
BMOR: 101738100
BMAN: 114244907
MSEX: 115441674
BANY: 112051080
PMAC: 106714422
PXU: 106124432
PRAP: 110994772
ZCE: 119829579
HAW: 110383759
TNL: 113496932
PXY: 105391295
API: 100166299
DNX: 107169491
AGS: 114120407
RMD: 113550707
BTAB: 109043968
CLEC: 106672663
HHAL: 106683879
NLU: 111048508
FOC: 113209019
ZNE: 110832815
CSEC: 111868775
FCD: 110842825
DMK: 116930060
PVM: 113825233
HAME: 121872041
HAZT: 108677517
DSV: 119442022
RSAN: 119387910
RMP: 119159729
TUT: 107366987
DPTE: 113791121
CSCU: 111629923
PTEP: 107452612
SDM: 118186307
CEL: CELE_C29F7.6(jmjd-3.3) CELE_D2021.1(utx-1) CELE_F18E9.5(jmjd-3.1) CELE_F23D12.5(jmjd-3.2)
TSP: Tsp_03329
PCAN: 112554796
BGT: 106056390
GAE: 121374746
CRG: 105317220
MYI: 110466209
PMAX: 117341825
OBI: 106880021
OSN: 115215415
LAK: 106181631
EGL: EGR_04225
NVE: 5510983
EPA: 110246134
ATEN: 116291785
ADF: 107353322
AMIL: 114966211
PDAM: 113675503
SPIS: 111334851
DGT: 114524716
HMG: 100197335
AQU: 100637155
 » show all
Reference
1  [PMID:17825402]
  Authors
De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G
  Title
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.
  Journal
Cell 130:1083-94 (2007)
DOI:10.1016/j.cell.2007.08.019
  Sequence
[hsa:23135]
Reference
2  [PMID:18003914]
  Authors
Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K
  Title
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
  Journal
Proc Natl Acad Sci U S A 104:18439-44 (2007)
DOI:10.1073/pnas.0707292104
  Sequence
[hsa:7403 23135]
Reference
3  [PMID:17851529]
  Authors
Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y
  Title
A histone H3 lysine 27 demethylase regulates animal posterior development.
  Journal
Nature 449:689-94 (2007)
DOI:10.1038/nature06192
  Sequence
[hsa:7403 23135]
Reference
4  [PMID:17761849]
  Authors
Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R
  Title
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.
  Journal
Science 318:447-50 (2007)
DOI:10.1126/science.1149042
  Sequence
[hsa:7403]
Reference
5  [PMID:17923864]
  Authors
Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD
  Title
JMJD3 is a histone H3K27 demethylase.
  Journal
Cell Res 17:850-7 (2007)
DOI:10.1038/cr.2007.83
  Sequence
[hsa:23135]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.68
IUBMB Enzyme Nomenclature: 1.14.11.68
ExPASy - ENZYME nomenclature database: 1.14.11.68
BRENDA, the Enzyme Database: 1.14.11.68

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