KEGG   ENZYME: 1.14.13.227
Entry
EC 1.14.13.227              Enzyme                                 
Name
propane 2-monooxygenase;
prmABCD (gene names)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
propane,NADH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
propane + NADH + H+ + O2 = propan-2-ol + NAD+ + H2O [RN:R10702]
Reaction(KEGG)
R10702
Substrate
propane [CPD:C20783];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
propan-2-ol [CPD:C01845];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.
History
EC 1.14.13.227 created 2016
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Orthology
K18223  propane 2-monooxygenase large subunit
K18224  propane 2-monooxygenase small subunit
Genes
GAIIMCC3135_23930(mmoY) IMCC3135_23940(mmoX)
BCAIK788_0003073 K788_0003075
PHSC2L64_20505 C2L64_20515
PACPFAZ97_27890 FAZ97_27900
CABASBC2_62630(prmA_2) SBC2_62650(prmC_2)
VEIVeis_4409 Veis_4411
MPTMpe_A0950(prmA) Mpe_A0952(ormC)
METPC1M51_04490 C1M51_04500
XYKGT347_05725 GT347_05735
AZOazo1219 azo1221
AOAdqs_1334 dqs_1336
AZRCJ010_07485 CJ010_07495
MAMOA6B35_24800 A6B35_24810
MESMEJ066_17145 EJ066_17155
MOHIHQ72_18715 IHQ72_18725
AAKAA2016_6220 AA2016_6223
RJGCCGE525_05445 CCGE525_05455
BJAblr3677(blr3677) blr3679(blr3679)
BJUBJ6T_61670 BJ6T_61690
BJPRN69_29860 RN69_29870
BRABRADO4348 BRADO4350
BBTBBta_3630 BBta_3632
AOLS58_14660 S58_14680
BICLMTR13_17510 LMTR13_17520
BOTCIT37_20150 CIT37_20160
BSEPHAP48_0008250 HAP48_0008260
BQBJ4P68_0027300 J4P68_0027310
BBANJ4G43_042520 J4G43_042530
STARG3545_26545 G3545_26555
LNEFZC33_06715 FZC33_06725
BIDBind_3395 Bind_3397
MSLMsil_1649 Msil_1651
MTUNMTUNDRAET4_0144.1(prmC) MTUNDRAET4_0146.1(prmA)
PLEOOHA_1_03553(mmoY) OHA_1_03555(mmoX)
HDIHDIA_3874(mmoY) HDIA_3876(mmoX)
JIEOH818_18920
PGDGal_01406 Gal_01408
MALGMALG_01260 MALG_01262
PABYGa0080574_TMP3298 Ga0080574_TMP3300
AHTANTHELSMS3_04149(mmoY) ANTHELSMS3_04151(mmoX)
MALUKU6B_14980 KU6B_15000
PALXGQA70_22650 GQA70_22660
RSPRSP_2792 RSP_2794
RSHRsph17029_1506 Rsph17029_1508
RSKRSKD131_1174 RSKD131_1176
PAMIJCM7686_pAMI4p208 JCM7686_pAMI4p211
GFUKM031_18825 KM031_18835
ACRAcry_1379 Acry_1381
AMVACMV_14260(prmC) ACMV_14280(prmA)
AZLAZL_c02870 AZL_c02890
ALIAZOLI_p10730(prmC) AZOLI_p10732(prmA)
ATIAL072_26915 AL072_26925
AZZDEW08_25720 DEW08_25730
AOZHUE56_03135 HUE56_03145
SKTIGS68_06155 IGS68_06165
SMUCJL100_021455 JL100_021465 JL100_032495 JL100_032505
SROEJL101_020155 JL101_020165
BTSBtus_1550 Btus_1552 Btus_2036
PANCE2636_01275 E2636_01285
SAYTPY_3182 TPY_3184
SAPSulac_1731 Sulac_1734
MSAMycsm_01477 Mycsm_01479
MPSEMPSD_01250
MSHOMSHO_12020
MGOAFA91_29110 AFA91_29120
MDXBTO20_38070
MSIMMSIM_49440 MSIM_49470
MCROMI149_22725
MSMMSMEG_1971
MSGMSMEI_1927 MSMEI_1929
MSBLJ00_09835 LJ00_09845
MSNLI99_09835 LI99_09845
MSHLI98_09835 LI98_09845
MCBMycch_5463 Mycch_5465
MLLB1R94_07255 B1R94_07265
MMAGMMAD_31800
MTYMTOK_17290 MTOK_17310
MHEVMHEL_18730
MTER4434518_02253(mmoX) 4434518_02255(mmoY)
MHIBMHIB_39860 MHIB_39880
ASDAS9A_2157 AS9A_2159
NFRERS450000_02058(mmoY) ERS450000_02060(mmoX)
RHARHA1_ro00441 RHA1_ro00443
ROAPd630_LPD04550 Pd630_LPD04552
RAVAAT18_26335 AAT18_26345
RFAA3L23_02106(mmoY) A3L23_02108(mmoX)
RHSA3Q41_01275(mmoX) A3Q41_01277(mmoY)
RHWBFN03_06840 BFN03_06850
RRZCS378_15775 CS378_15785
RHODAOT96_22160 AOT96_22170
RCRNCTC10994_02802(mmoX) NCTC10994_02804(mmoY)
RKOJWS14_19305 JWS14_19315
ROZCBI38_04455 CBI38_04465
RPSKJWS13_25460 JWS13_25470
GBRGbro_3551 Gbro_3553
GPOGPOL_c34280 GPOL_c34300
GORKTR9_3575 KTR9_3577
GTABCM27_18320 BCM27_18330
GRUGCWB2_18380(mmoX) GCWB2_18390(mmoY)
GOMD7316_05134(mmoY) D7316_05136(mmoX)
GAVC5O27_09755 C5O27_09765
GODGKZ92_17365 GKZ92_17375
GAMGII34_01545 GII34_01555
GJIH1R19_17090 H1R19_17100
GAMIIHQ52_21135 IHQ52_21145
GMGNWF22_02570 NWF22_02580
ARTYAHiyo4_21320 AHiyo4_21340
NDKI601_2091(mmoX) I601_2093(mmoY)
NPSKRR39_09015 KRR39_09025
KQIF1D05_01950 F1D05_01960
FRAFrancci3_2518 Francci3_2520
SACGFDZ84_37200 FDZ84_37210
AMDAMED_4324 AMED_4326
AMNRAM_22015 RAM_22025
AMMAMES_4272 AMES_4274
AMZB737_4272 B737_4274
AMQAMETH_2368 AMETH_2370 AMETH_4324 AMETH_4326
AMYBBKN51_07845 BKN51_07855
AACDLWP59_05735 LWP59_05745 LWP59_20300 LWP59_20310
APRTMUY14_15865 MUY14_15875
PDXPsed_0629 Psed_0631
PSEAWY02_19390 WY02_19400
PSEEFRP1_23450 FRP1_23460
PSEHXF36_22070 XF36_22080
PSEQAD006_02645 AD006_02655
PECQAD017_10460 AD017_10470
PHHAFB00_07920 AFB00_07930
PAUTPdca_07470 Pdca_07490
PBROHOP40_04720 HOP40_04730
PPELH6H00_05165 H6H00_05175
RUBGBA63_12420 GBA63_12430
PARNNBH00_09495 NBH00_09500 NBH00_21780 NBH00_21790
 » show all
Reference
1  [PMID:14645271]
  Authors
Kotani T, Yamamoto T, Yurimoto H, Sakai Y, Kato N
  Title
Propane monooxygenase and NAD+-dependent secondary alcohol dehydrogenase in propane metabolism by Gordonia sp. strain TY-5.
  Journal
J Bacteriol 185:7120-8 (2003)
DOI:10.1128/JB.185.24.7120-7128.2003
Reference
2  [PMID:17873074]
  Authors
Sharp JO, Sales CM, LeBlanc JC, Liu J, Wood TK, Eltis LD, Mohn WW, Alvarez-Cohen L
  Title
An inducible propane monooxygenase is responsible for N-nitrosodimethylamine degradation by Rhodococcus sp. strain RHA1.
  Journal
Appl Environ Microbiol 73:6930-8 (2007)
DOI:10.1128/AEM.01697-07
Reference
3  [PMID:21183637]
  Authors
Furuya T, Hirose S, Osanai H, Semba H, Kino K
  Title
Identification of the monooxygenase gene clusters responsible for the regioselective oxidation of phenol to hydroquinone in mycobacteria.
  Journal
Appl Environ Microbiol 77:1214-20 (2011)
DOI:10.1128/AEM.02316-10
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.227
IUBMB Enzyme Nomenclature: 1.14.13.227
ExPASy - ENZYME nomenclature database: 1.14.13.227
BRENDA, the Enzyme Database: 1.14.13.227

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