albendazole oxidase (misleading);
albendazole sulfoxidase (ambiguous);
FMO3 (gene name);
albendazole monooxygenase (flavin-containing)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)
albendazole + NADPH + H+ + O2 = albendazole S-oxide + NADP+ + H2O [RN:
A microsomal flavin-containing monooxygenase. A similar conversion is also carried out by some microsomal cytochrome P-450 enzymes [EC
, albendazole monooxygenase (sulfoxide-forming)]. It is estimated that cytochrome P-450s are responsible for 70% of the activity.
EC 126.96.36.199 created 1989, modified 2018
K17689 cytochrome P450 family 3 subfamily A4
PTEH: 111530171 111534893
MMUR: 105868328 105868331 » show all
Fargetton X, Galtier P, Delatour P.
Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes.
Moroni P, Buronfosse T, Longin-Sauvageon C, Delatour P, Benoit E
Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes.
Drug Metab Dispos 23:160-5 (1995)
Rawden HC, Kokwaro GO, Ward SA, Edwards G.
Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes.