KEGG   ENZYME: 1.14.13.39
Entry
EC 1.14.13.39               Enzyme                                 
Name
nitric-oxide synthase (NADPH);
NOS (gene name);
nitric oxide synthetase (ambiguous);
endothelium-derived relaxation factor-forming enzyme;
endothelium-derived relaxing factor synthase;
NO synthase (ambiguous);
NADPH-diaphorase (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Reaction(IUBMB)
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O (overall reaction) [RN:R00557];
(1a) 2 L-arginine + 2 NADPH + 2 H+ + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 NADP+ + 2 H2O  [RN:R00558];
(1b) 2 Nomega-hydroxy-L-arginine + NADPH + H+ + 2 O2 = 2 L-citrulline + 2 nitric oxide + NADP+ + 2 H2O [RN:R00111]
Reaction(KEGG)
Substrate
L-arginine [CPD:C00062];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007];
Nomega-hydroxy-L-arginine
Product
L-citrulline [CPD:C00327];
nitric oxide [CPD:C00533];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
Nomega-hydroxy-L-arginine
Comment
The enzyme consists of linked oxygenase and reductase domains. The eukaryotic enzyme binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin, and its two domains are linked via a regulatory calmodulin-binding domain. Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. The reductase domain of the enzyme from the bacterium Sorangium cellulosum utilizes a [2Fe-2S] cluster to transfer the electrons from NADPH to the active center. cf. EC 1.14.14.47, nitric-oxide synthase (flavodoxin).
History
EC 1.14.13.39 created 1992, modified 2012, modified 2017
Pathway
ec00220  Arginine biosynthesis
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13240  nitric-oxide synthase, brain
K13241  nitric-oxide synthase, inducible
K13242  nitric-oxide synthase, endothelial
K13427  nitric-oxide synthase, plant
Genes
HSA4842(NOS1) 4843(NOS2) 4846(NOS3)
PTR455026(NOS2) 463893(NOS3) 467139(NOS1)
PPS100974638(NOS3) 100976546(NOS2) 100996089(NOS1)
GGO101128007(NOS3) 101134923(NOS2) 101147071(NOS1)
PON100433069(NOS1) 100436584(NOS2) 100447953(NOS3)
NLE100589003(NOS2) 100592456(NOS3) 100597250(NOS1)
MCC114673005 693781(NOS1) 706921(NOS2) 714231(NOS3)
MCF102121432(NOS2) 102123521(NOS1) 102143504(NOS3)
CSAB103227233(NOS3) 103242598 103242600(NOS2)
CATY105584734(NOS3) 105591502(NOS2) 105592744(NOS1)
PANU101019718 101024888(NOS3) 101025542(NOS1)
TGE112609895(NOS2) 112620359(NOS3) 112634545(NOS1)
RRO104669357(NOS2) 104675393(NOS3) 104675533(NOS1)
RBB108532525(NOS3) 108539288(NOS1) 108539959(NOS2)
TFN117067605(NOS2) 117072600(NOS3) 117089332(NOS1)
PTEH111520811(NOS2) 111537519(NOS1) 111551457(NOS3)
CJC100403192(NOS2) 100405019(NOS3) 100895717(NOS1)
SBQ101034220(NOS3) 101034544(NOS1) 101041016(NOS2)
CSYR103250172 103274370(NOS2) 103275280(NOS3)
MMUR105857991(NOS2) 105866961(NOS1) 105883168(NOS3)
OGA100946509(NOS1) 100956703(NOS3) 100958618(NOS2)
MMU18125(Nos1) 18126(Nos2) 18127(Nos3)
MCAL110293897(Nos3) 110294416(Nos1) 110304621(Nos2)
MPAH110312876(Nos1) 110315110(Nos3) 110331408(Nos2)
RNO24598(Nos1) 24599(Nos2) 24600(Nos3)
MCOC116068288(Nos1) 116076938(Nos2) 116097543(Nos3)
MUN110550157(Nos2) 110551884(Nos1) 110562552(Nos3)
CGE100758127(Nos1) 100760062(Nos2) 100769961(Nos3)
MAUA101823656(Nos2) 101830457(Nos1) 101838293(Nos3)
PLEU114691518(Nos2) 114699651(Nos1) 114700088(Nos3)
MORG121439958(Nos3) 121445990(Nos1) 121456433(Nos2)
NGI103724501(Nos2) 103745303(Nos3) 103745523(Nos1)
HGL101699617(Nos2) 101711110(Nos3) 101711993(Nos1)
CPOC100135576(Nos2) 100135577(Nos3) 100729682(Nos1)
CCAN109686387(Nos1) 109693015(Nos2) 109694442(Nos3)
DORD105984213(Nos1) 105985658(Nos2) 105993873(Nos3)
DSP122099033(Nos1) 122105913(Nos3) 122120264(Nos2)
NCAR124979775 124990691 124991150
OCU100008833(NOS2) 100009243(NOS1) 100009498(NOS3)
OPI101520691(NOS3) 101522087(NOS1) 101535394(NOS2)
TUP102471872(NOS2) 102480558(NOS1) 102495986(NOS3)
CFA403784(NOS3) 403822(NOS2) 477498(NOS1)
VVP112916218(NOS3) 112932933(NOS1) 112933146(NOS2)
VLG121472657(NOS2) 121475796(NOS1) 121489275(NOS3)
AML100468087(NOS1) 100470060(NOS2) 100483990(NOS3)
UMR103660958(NOS3) 103661304(NOS1) 103667420(NOS2)
UAH113241474(NOS3) 113266817(NOS1) 113269018(NOS2)
UAR123776978(NOS2) 123778556(NOS1) 123788781(NOS3)
ELK111151537 111154402 111156411
LLV125081326 125082424 125087863
MPUF101673532(NOS3) 101692439(NOS1) 101694448(NOS2)
ORO101375441(NOS1) 101380967(NOS2) 101382350(NOS3)
EJU114198019(NOS3) 114214012(NOS2) 114219124(NOS1)
ZCA113907948(NOS2) 113911718(NOS3) 113913115(NOS1)
MLX118018518(NOS1) 118025303(NOS2) 118026800(NOS3)
FCA101087020(NOS2) 101096463(NOS3) 101100342(NOS1)
PYU121010269(NOS1) 121017178(NOS2) 121022952(NOS3)
PBG122470274(NOS1) 122485185(NOS2) 122488527(NOS3)
PTG102950049(NOS2) 102962715(NOS1) 102967516(NOS3)
PPAD109251875(NOS2) 109252365(NOS3) 109277571(NOS1)
AJU106969560(NOS3) 106971710(NOS1) 106984382(NOS2)
HHV120230927(NOS3) 120232363(NOS1) 120246360(NOS2)
BTA282876(NOS2) 287024(NOS3) 536132(NOS1)
BOM102265893(NOS2) 102267556(NOS3) 102280537(NOS1)
BIU109557793(NOS3) 109571319(NOS1) 109574459(NOS2)
BBUB102400136(NOS1) 102401026(NOS2) 102408451(NOS3)
CHX100860742(NOS2) 102185338(NOS3) 102185490(NOS1)
OAS443077(NOS3) 443078(NOS2) 443533(NOS1)
ODA120866313(NOS2) 120871573(NOS1) 120877875(NOS3)
CCAD122423224(NOS1) 122448629(NOS2)
SSC100520934(NOS1) 396859(NOS2) 397557(NOS3)
CFR102508946(NOS1) 102518523(NOS2) 102524296(NOS3)
CBAI105067010(NOS3) 105071584(NOS2) 105075702(NOS1)
CDK105088198(NOS2) 105104911(NOS1) 105105831(NOS3)
VPC102534932(NOS2) 102536194(NOS3) 102542069(NOS1)
BACU103003780(NOS2) 103008209(NOS1) 103017861(NOS3)
LVE103074308(NOS2) 103087259(NOS3) 103090138(NOS1)
OOR101273057(NOS1) 101280520(NOS3) 101280638(NOS2)
DLE111176849(NOS3) 111185989 111186931(NOS1)
PCAD102985806(NOS3) 102990905(NOS2) 102991967(NOS1)
PSIU116738822(NOS1) 116745263(NOS2) 116759107(NOS3)
ECB100051079(NOS1) 100063339(NOS3) 791246(NOS2)
EPZ103540937(NOS3) 103547950(NOS1) 103567002
EAI106823361(NOS3) 106839766(NOS1) 106844596(NOS2)
MYB102253125(NOS2) 102256555(NOS3) 102260489(NOS1)
MYD102763635(NOS1) 102764374(NOS3) 102768087(NOS2)
MMYO118672123(NOS2) 118678505(NOS1) 118679429(NOS3)
MLF102424107(NOS2) 102433074(NOS1) 102436714(NOS3)
MNA107524933(NOS3) 107528483(NOS1) 107533063(NOS2)
PKL118702516(NOS2) 118704763(NOS3) 118725282(NOS1)
HAI109382238(NOS1) 109385084(NOS2) 109389680(NOS3)
DRO112308288(NOS3) 112308600(NOS2) 112310614(NOS1)
SHON118975507(NOS3) 118991149(NOS1) 119003495(NOS2)
AJM119039263(NOS3) 119057483(NOS1) 119062015(NOS2)
PDIC114503016(NOS2) 114508069(NOS3) 114509381(NOS1)
PHAS123817124(NOS2) 123817951(NOS3) 123820989(NOS1)
MMF118620067(NOS3) 118634857(NOS2) 118639832(NOS1)
RFQ117012675(NOS2) 117017522(NOS1) 117018217(NOS3)
PALE102878456(NOS2) 102879945(NOS3) 102884569(NOS1)
PGIG120601518(NOS3) 120606760(NOS1) 120620943(NOS2)
PVP105289401(NOS1) 105291934(NOS2) 105303769(NOS3)
RAY107497410(NOS2) 107513162(NOS1) 107520319(NOS3)
MJV108391841(NOS3) 108397044(NOS2) 108397443(NOS1)
TOD119231002(NOS2) 119244938(NOS1) 119251590(NOS3)
SARA101547011(NOS3) 101548820(NOS2) 101559239(NOS1)
LAV100668912(NOS3) 100673992(NOS1) 100676634(NOS2)
TMU101342004 101356579 101356953
DNM101411311(NOS1) 101433723(NOS3) 101440596(NOS2)
MDO100013712(NOS1) 100018035(NOS3) 100024271(NOS2)
GAS123247380(NOS2) 123250621(NOS3) 123256892(NOS1)
SHR100913437(NOS3) 100921140(NOS1) 100927789(NOS2)
PCW110192171(NOS2) 110201937(NOS3) 110222812(NOS1)
OAA100075386(NOS2) 100091599(NOS3) 100093259(NOS1)
GGA107057170 395807(NOS2) 427721(NOS1)
PCOC116227904(NOS2) 116228339(NOS1) 116242834(NOS3)
MGP100538441(NOS1) 100545552 692136(NOS2)
CJO107308662(NOS3) 107321466(NOS1) 107322733(NOS2)
NMEL110406170(NOS1) 110407551(NOS2)
APLA101798766(NOS1) 101804455(NOS2)
ACYG106043795(NOS2) 106045554(NOS1)
AFUL116486135(NOS3) 116496320(NOS1) 116497109(NOS2)
TGU100230954(NOS2) 100231414(NOS1) 115493592(NOS3) 116807264
LSR110471958(NOS2) 110474155(NOS1) 110475121(NOS3)
SCAN103818226(NOS1) 103820198(NOS2)
PMOA120507736(NOS2) 120510300(NOS1) 120510540(NOS3)
OTC121334878(NOS3) 121344475(NOS1) 121347051(NOS2)
PRUF121356981(NOS3) 121361668(NOS2) 121364923(NOS1)
GFR102042821(NOS1) 102044468(NOS2)
FAB101817488(NOS2) 101820761(NOS1)
PHI102106809(NOS1) 102108817(NOS2) 102112141(NOS3)
PMAJ107211573(NOS1) 107212812(NOS2)
CCAE111936662(NOS1) 111937881(NOS2)
CCW104690967(NOS2) 104695038(NOS1)
ETL114057504(NOS2) 114068013(NOS3) 114071586(NOS1)
ZAB102070665(NOS2) 102072905(NOS1)
FPG101916747(NOS1) 101918492(NOS3) 101921726(NOS2)
FCH102047821(NOS1) 102048023(NOS2) 102057360(NOS3)
CLV102086291(NOS2) 102093432(NOS1)
EGZ104121908(NOS2) 104129871(NOS1)
NNI104010553(NOS1) 104016248(NOS2)
ACUN113486129(NOS1) 113487234(NOS2)
TALA104361402(NOS1) 104367550(NOS2)
PADL103912519(NOS2) 103913684(NOS1)
ACHC115346336(NOS1) 115346926(NOS2)
AAM106493898(NOS1) 106498669(NOS2)
AROW112963744(NOS3) 112968206(NOS2) 112976786(NOS1)
NPD112950374(NOS1) 112954567(NOS2) 112958193
DNE112978916 112987008(NOS2) 112994650(NOS1)
ASN102375419(NOS2) 102380334(NOS1) 102381196(NOS3)
AMJ102561243(NOS1) 102575253(NOS3) 106737013(NOS2)
CPOO109312966(NOS1) 109317113(NOS2)
GGN109290264(NOS1) 109293229(NOS2)
PSS102444149(NOS1) 102446334(NOS2)
CMY102941829(NOS1) 102942806(NOS3) 102946684(NOS2)
CPIC101937660(NOS1) 101941684(NOS2) 101952927(NOS3)
TST117867669(NOS2) 117871954(NOS3) 117888179(NOS1)
CABI116824205(NOS2) 116834210 116836436(NOS1)
MRV120386165(NOS1) 120387127(NOS2) 120397587(NOS3)
ACS100557597(nos3) 100561200(nos2) 100562233(nos1)
PVT110082598(NOS3) 110088446(NOS2) 110090104(NOS1)
SUND121916538(NOS1) 121917020 121934954(NOS3)
PBI103051066(NOS2) 103052972(NOS1) 103065136
PMUR107295430(NOS1) 107296204(NOS2)
TSR106544793(NOS3) 106555338(NOS2)
PGUT117657845(NOS1) 117667437(NOS2) 117669221(NOS3)
VKO123019550(NOS3) 123023387(NOS2) 123032750(NOS1)
PMUA114585803(NOS2) 114587067(NOS1) 114607850(NOS3)
ZVI118075983(NOS1) 118092264(NOS3) 118097243(NOS2)
GJA107112296(NOS1) 107118610(NOS3) 107119447(NOS2)
STOW125425385 125441159(NOS3) 125442897(NOS1)
XLA108704634(nos3.L) 108707179(nos1.S) 108708038(nos2.L) 108708888(nos2.S) 373705(nos1.L)
XTR100486016(nos3) 100494698(nos2) 100497595(nos1)
NPR108785232(NOS1) 108801680(NOS2) 108803428
RTEM120927627(NOS2) 120932977(NOS1) 120941752(NOS3)
BBUF120991402(NOS1) 120994733(NOS2) 121000747(NOS3)
BGAR122930441 122931705 122935037(NOS1) 122938595 122938785
DRE404036(nos2a) 563654(nos2b) 60658(nos1)
SRX107719931 107726721 107755829(nos1) 107756441
SANH107660266 107666185 107668720 107683435(nos2) 107704495(nos1)
SGH107553584 107588374 107592916(nos2) 107599142(nos1) 107599638
CCAR109079125 109079156 109080897 109103595 109103596
CAUA113058570 113068104 113072250 113075348 113078755 113114808
PPRM120461686(nos2a) 120470411(nos1) 120473191(nos2b)
MAMB125249596(nos2b) 125267321(nos1) 125267422(nos2a)
IPU108255344(nos1) 108277518 108278375(nos2b)
PHYP113537215(nos1) 113539231 113539397
SMEO124380832(nos1) 124395037 124395094
TFD113645314 113645328 113653396(nos1)
AMEX103026958 103031688 103046065(nos1)
EEE113577767(nos1) 113591429
TRU101066909(nos1)
TNGGSTEN00029052G001
LCO104923687(nos1)
NCC104967506(nos1)
CGOB115014031(nos1)
ELY117252891(nos1)
PLEP121943974(nos1)
SLUC116054158(nos1)
ECRA117944931(nos1)
PFLV114555256(nos1)
GAT120830799(nos1)
PPUG119225179(nos1)
MSAM119892185(nos1)
CUD121510247(nos1)
ALAT119019240(nos1)
MZE101485683(nos1)
ONL100534582(nos1)
OAU116325579(nos1)
OLA100049502(nos1)
OML112148312(nos1)
XMA102233853(nos1)
XCO114154866(nos1)
XHE116729879(nos1)
PRET103469871(nos1)
PFOR103134950(nos1)
PLAI106945253(nos1)
PMEI106919449(nos1)
GAF122827934(nos1)
CVG107087335(nos1)
CTUL119788886(nos1)
GMU124878013(nos1)
NFU107386248(nos1)
KMR108246938(nos1)
ALIM106519449(nos1)
NWH119413183(nos1)
AOCE111572539(nos1)
CSEM103396877 103397851(nos1)
POV109637139(nos1)
SSEN122769681(nos1)
HHIP117768184(nos1)
HSP124852411(nos1)
LCF108903114(nos1)
SDU111227324(nos1)
SLAL111663111(nos1)
XGL120805277(nos1)
HCQ109525272(nos1)
BPEC110155016(nos1)
MALB109959109(nos1)
BSPL114862412(nos1)
SASA100136358(nos2) 100136388(nos1) 106585241
OTW112248861(nos1) 112262564 112266155 112267222
OMY100136036(nos2) 100136347(nos1) 110507147 110535113
OGO124005468 124034044(nos1) 124035286
ONE115111915(nos1) 115115929 115141939
SALP111949918 111958203 111960727(nos2) 111974596
SNH120018738 120028669 120043829(nos1) 120062808
ELS105013989(nos2) 105031277(nos1) 109615805
SFM108927312(nos1) 108932266(nos2)
PKI111851114 111852748(nos1) 111856407(nos2)
AANG118206631(nos1)
LOC102692649(nos2) 102697373 102699252(nos1)
PSPA121296840 121299518 121308730(nos2b) 121312985 121314660
ARUT117394670 117394704 117400058 117426910 117428352 117429557 117430593
LCM102348281(NOS1) 102354990(NOS2)
CMK103183299(nos2b) 103184386(nos1)
RTP109914181(nos1) 109922224 109927199(nos2)
BFO118404760 118413899 118426508
BBEL109469130 109475091 109479447
CIN100183039
SCLV120325991 120326000
SPU100888109 587111
APLC110976884 110976936
DMEDmel_CG6713(Nos)
DER6542987
DSE6612066
DSIDsimw501_GD22223(Dsim_GD22223)
DYADyak_GE13295
DAN6496893
DSR110183462
DPODpse_GA19805
DPE6596585
DMN108163699
DWI6641760
DGR6566802
DMODmoj_GI17812
DAZ108609612
DNV108658145
DHE111601524
DVI6629111
CCAT101456696 101457075
BOD106620796 106621192
MDE101891936
SCAC106083069
LCQ111681704
LSQ119604749
HIS119651134
AGAAgaP_AGAP008255 AgaP_AGAP008257
ACOZ120957719
AARA120901512
ASTE118512972
AAG5572370
AALB109402508 109416795
CQUCpipJ_CPIJ000366 CpipJ_CPIJ019871
CPII120432426
CNS116341093
BCOO119078115 119080983 119085893
AME503861(NOS)
ACER107998213
ALAB122712365
BIM100749227
BBIF117209160
BVK117239566
BVAN117165749
BTER100650517
BPYO122566286
CCAL108625325
OBB114871710
MGEN117222304
NMEA116434882
CGIG122398338
SOC105200228
MPHA105829748
AEC105149468
ACEP105625167
PBAR105432905
VEM105557978
HST105183230
DQU106744004
CFO105250272
FEX115240251
LHU105675559
PGC109856190
OBO105286125
PCF106793080
PFUC122516940
VPS122628777
NVI100313941(Nos)
CSOL105360744
MDL103570884
CGLO123264608
FAS105263042
DAM107044602
AGIF122848352
CCIN107269169
TCA655549
DPA109546644
SOY115884119
ATD109603629 109606901
CSET123313082
AGB108908391
LDC111501949
NVL108558954
APLN108740077
PPYR116177033 116177043
OTU111427474
BMOR100144542(NOS2) 692510(NOS1)
BMAN114243188 114243206
MSEX115445277 115445279
DPLKGM_202094
BANY112048436 112048444
PMAC106718432 106718546
PPOT106104091 106105182
PXU106128430 106128432
PRAP110995634 110995640
ZCE119834982 119834983
HAW110378704 110378714
TNL113504450 113504511 113504548
SLIU111351570 111351952
OFU114365595 114365602
PXY105388815 105388816
API100160390
DNX107172687
AGS114128082
RMD113551041
BTAB109031807
DCI103519178
CLEC106661589
HHAL106678228
NLU111044297
PHUPhum_PHUM176630
FOC113213110
TPAL117639716
ZNE110828058
CSEC111862897
FCD110850636
DPXDAPPUDRAFT_314346 DAPPUDRAFT_49977
DMK116926468 116928975
PVM113823177 113828626
PJA122253978
PCHN125024535 125035227
HAME121863979
PCLA123754516 123754968 123755062 123759937
PTRU123510911
HAZT108677990
PPOI119099496
ISCIscW_ISCW018074
DSV119446119
RSAN119390050
RMP119161273
TUT107370056
DPTE113792010
DFR124499006
CSCU111619022 111620432 111620451
PTEP107440636
SDM118194050 118197261
LGILOTGIDRAFT_197993
PCAN112563084
GAE121368198 121368682 121390711 121391199
HRF124112147 124116041 124116043 124150822
HRJ124254027 124254028 124275692 124278491
CRG105322950
MYI110460719
PMAX117333205
MMER123533726
LAK106163703 106169208 106176019
NVE5511062
EPA110253339
ATEN116290507 116290867
ADF107337967 107341488 107355966
AMIL114957458 114967140
PDAM113685754
SPIS111339078 111345090
DGT114523867 114524113
XEN124433818
TADTRIADDRAFT_18893 TRIADDRAFT_19964 TRIADDRAFT_31504
ATHAT3G47450(NOA1)
ALY9311909
CRB17885274
CSAT104711205 104780543 104790952
EUSEUTSA_v10010252mg
BRP103873244
BNA106435290 106451204
BOE106336370
RSZ108805938
THJ104819450
CPAP110823388
CIT102609531
CICCICLE_v10004670mg
PVY116126567
MINC123224715
TCC18605348
GRA105764892
GHI107933448 107955121
GAB108476635
DZI111291243
EGR104449744
GMX100781340 100798614
GSJ114378370 114425871
PVUPHAVU_011G015300g
VRA106779222
VAR108338876
VUN114168311
CCAJ109799300
APRC113864763
MTRMTR_2g060420
CAM101502582
LJALj3g3v3640230.1(Lj3g3v3640230.1) Lj3g3v3640230.2(Lj3g3v3640230.2)
ADU107477402
AIP107629644
AHF112737290 112789366
LANG109346733
FVE101301911 101307253
RCN112194641
PPER18787454
PMUM103333445
PAVI110764709
PDUL117617733
MDM103439617
PXB103959816 103961947
ZJU107408397 107414210
MNT21390065
CSV101215455
CMO103504692
BHJ120068223
MCHA111026165
CMAX111468852
CMOS111435614
CPEP111808842
RCU8289609
JCU105648618
HBR110662682 110663877
MESC110609785
POP18094012
PEU105121408
PALZ118036030
JRE109021608
QSU111998951 112029395 112040032
QLO115959749
TWL119984064
VVI100265605
VRI117908764
SLY778272
SPEN107014849
SOT102577659
CANN107863453
NTA107785662 107819728(NOS1)
NSY104222140
NTO104094540
NAU109209591
INI109151404
ITR116020980
SIND105160612
OEU111390921
EGT105971858
SSPL121755293 121756935
HAN110915439
ECAD122587094
LSV111901618
CCAV112521376
DCR108219256
CSIN114302122
BVG104906620
SOE110782360
CQI110689346 110717554
NNU104602366
MING122064357
TSS122664231
PSOM113297229 113302433
NCOL116253542
OSA4328006
DOSAOs02t0104700-01(Os02g0104700)
OBR102721991
BDI100824396
ATS109734442
TDC119319238 119323707
TAES123131611 123135406 123142968
TUA125513964
SBI8066480
ZMA100381773
SITA101766392
SVS117849152
PVIR120654364 120661573
PHAI112884304
PDA103710739
EGU105059520
MUS103973495
DCT110108324
PEQ110019759
AOF109822646
ATR18428833
SMOSELMODRAFT_164227 SELMODRAFT_87746
PPP112284854
VCNVOLCADRAFT_120437
MNGMNEG_12684
CSLCOCSUDRAFT_26953
CVRCHLNCDRAFT_141029
APROF751_5878
OTAOT_ostta04g02630 OT_ostta17g00030
BPGBathy06g04850
MISMICPUN_58144
CFJCFIO01_00348
NPAUCRNP2_4118
TANTA14095
 » show all
Reference
1  [PMID:1689048]
  Authors
Bredt DS, Snyder SH.
  Title
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
  Journal
Proc Natl Acad Sci U S A 87:682-5 (1990)
DOI:10.1073/pnas.87.2.682
Reference
2  [PMID:1706713]
  Authors
Stuehr DJ, Kwon NS, Nathan CF, Griffith OW, Feldman PL, Wiseman J
  Title
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
  Journal
J Biol Chem 266:6259-63 (1991)
Reference
3  [PMID:11279231]
  Authors
Stuehr D, Pou S, Rosen GM
  Title
Oxygen reduction by nitric-oxide synthases.
  Journal
J Biol Chem 276:14533-6 (2001)
DOI:10.1074/jbc.R100011200
Reference
4  [PMID:19805284]
  Authors
Agapie T, Suseno S, Woodward JJ, Stoll S, Britt RD, Marletta MA
  Title
NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum.
  Journal
Proc Natl Acad Sci U S A 106:16221-6 (2009)
DOI:10.1073/pnas.0908443106
Reference
5  [PMID:21119059]
  Authors
Foresi N, Correa-Aragunde N, Parisi G, Calo G, Salerno G, Lamattina L
  Title
Characterization of a nitric oxide synthase from the plant kingdom: NO generation from the green alga Ostreococcus tauri is light irradiance and growth phase dependent.
  Journal
Plant Cell 22:3816-30 (2010)
DOI:10.1105/tpc.109.073510
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.39
IUBMB Enzyme Nomenclature: 1.14.13.39
ExPASy - ENZYME nomenclature database: 1.14.13.39
BRENDA, the Enzyme Database: 1.14.13.39
CAS: 125978-95-2

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