KEGG   ENZYME: 1.14.13.7
Entry
EC 1.14.13.7                Enzyme                                 
Name
phenol 2-monooxygenase (NADPH);
phenol hydroxylase;
phenol o-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O [RN:R00815]
Reaction(KEGG)
R00815;
(other) R03566 R03568
Substrate
phenol [CPD:C00146];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). The enzyme from the fungus Trichosporon cutaneum has a broad substrate specificity, and has been reported to catalyse the hydroxylation of a variety of substituted phenols, such as fluoro-, chloro-, amino- and methyl-phenols and also dihydroxybenzenes. cf. EC 1.14.14.20, phenol 2-monooxygenase (FADH2).
History
EC 1.14.13.7 created 1972, modified 2011, modified 2016
Pathway
ec00623  Toluene degradation
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K03380  phenol 2-monooxygenase (NADPH)
Genes
PXB103942874
QSU111991203 112020508
DHADEHA2C14784g
PICPICST_57166(PHH2)
SPAASPAPADRAFT_59206
LELLELG_04072
CALCAALFM_CR07820WA(CaO19.3711) CAALFM_CR07940WA(CaO19.604)
CTPCTRG_00423 CTRG_03102
COTCORT_0D06110
CDUCD36_33480 CD36_33600
SLBAWJ20_109 AWJ20_385
NCRNCU05188 NCU05708 NCU07916
NTENEUTE1DRAFT121791(NEUTE1DRAFT_121791) NEUTE1DRAFT61928(NEUTE1DRAFT_61928) NEUTE1DRAFT78296(NEUTE1DRAFT_78296)
SMPSMAC_02070 SMAC_03046 SMAC_07153
PANPODANSg2532 PODANSg3801 PODANSg603 PODANSg7748
MTMMYCTH_2119794 MYCTH_2303163
CTHRCTHT_0072300
MGRMGG_04639 MGG_08541
PPEIPpBr36_05413
TMNUCRPA7_6019
SSCKSPSK_00425 SPSK_04049
FGRFGSG_00489 FGSG_03199 FGSG_08228 FGSG_09110 FGSG_13839 FGSG_13983
FPUFPSE_01354 FPSE_02824 FPSE_05978 FPSE_06369
FVRFVEG_07692 FVEG_09986 FVEG_11003 FVEG_12251 FVEG_13906
FOXFOXG_04525 FOXG_11855 FOXG_13286 FOXG_13497 FOXG_17384
NHENECHADRAFT_41156 NECHADRAFT_44538 NECHADRAFT_56594 NECHADRAFT_64650 NECHADRAFT_87341 NECHADRAFT_89551 NECHADRAFT_97987
TRETRIREDRAFT_1751 TRIREDRAFT_69751
TRRM419DRAFT_121479 M419DRAFT_91131
MAWMAC_02939 MAC_03791 MAC_05453 MAC_08552
MAJMAA_04220 MAA_06132 MAA_07739
CMTCCM_03625 CCM_05662 CCM_09091
PLJVFPFJ_05073 VFPFJ_11745
VALVDBG_03513
VDAVDAG_09528
CFJCFIO01_01350 CFIO01_02839 CFIO01_06230 CFIO01_07088 CFIO01_07927
CLUPCLUP02_04436 CLUP02_09750
CHIGCH63R_01255 CH63R_03295 CH63R_13194
SAPOSAPIO_CDS0590 SAPIO_CDS6138 SAPIO_CDS6325 SAPIO_CDS6851 SAPIO_CDS8718
ELAUCREL1_2808 UCREL1_2985 UCREL1_4251 UCREL1_6609 UCREL1_7737 UCREL1_9068 UCREL1_9311
PFYPFICI_02524 PFICI_02860 PFICI_08061 PFICI_12581 PFICI_13333 PFICI_14690 PFICI_15196
SSLSS1G_08429 SS1G_13313
BFUBCIN_03g08120 BCIN_12g02320
MBEMBM_07857
PSCOLY89DRAFT_603506 LY89DRAFT_622223 LY89DRAFT_636654 LY89DRAFT_657322 LY89DRAFT_692336
GLZGLAREA_03287 GLAREA_04112 GLAREA_08867 GLAREA_09785
ANIAN0503.2 AN2075.2 AN3536.2 AN7418.2 AN8370.2 AN8592.2
AFMAFUA_1G13660 AFUA_2G00140 AFUA_2G01580 AFUA_3G02620 AFUA_6G03490 AFUA_6G11480
ACTACLA_008430 ACLA_021780 ACLA_059660 ACLA_085150 ACLA_093360
NFINFIA_007570 NFIA_011840 NFIA_028000 NFIA_032310 NFIA_033860 NFIA_045600 NFIA_057170
AORAO090001000010 AO090005000923 AO090010000367 AO090012000460 AO090012000510 AO090023000432 AO090026000121 AO090026000771
ANGANI_1_1148034(An03g02320) ANI_1_1858184(An04g04680) ANI_1_2070074(An08g06720) ANI_1_2320104(An12g10250) ANI_1_3124014(An01g11800) ANI_1_966134(An15g07050)
AFVAFLA_002180 AFLA_002233 AFLA_003744 AFLA_005514 AFLA_006183 AFLA_006777 AFLA_008359 AFLA_013857
ALUCAKAW2_10434S AKAW2_30409S AKAW2_40205S AKAW2_51457A AKAW2_61332A
ACHEACHE_10075A ACHE_41120A ACHE_60018A ACHE_60032S ACHE_80119A
APUUAPUU_11540S APUU_50019S APUU_51273A APUU_60078A APUU_61355S
PCSPc13g05120 Pc13g12480 Pc16g06090 Pc20g01980
PDPPDIP_26630
TMFPMAA_039180 PMAA_044850 PMAA_051690 PMAA_065420 PMAA_068610 PMAA_080250 PMAA_091080 PMAA_095530
TRGTRUGW13939_00901 TRUGW13939_01402 TRUGW13939_02567 TRUGW13939_03669 TRUGW13939_05966 TRUGW13939_06779 TRUGW13939_07862 TRUGW13939_09955
CIMCIMG_10045
CPWCPC735_011900
UREUREG_02861 UREG_04222 UREG_05983
PBLPAAG_01548 PAAG_03627 PAAG_04128
PBNPADG_00229 PADG_06199 PADG_07391
ABEARB_01796
TVETRV_06545
AJEHCAG_00662 HCAG_06866 HCAG_07587
BGHBDBG_01218 BDBG_08668 BDBG_09395
PNOSNOG_01149 SNOG_04185 SNOG_10050 SNOG_13970
PTEPTT_06930 PTT_08788 PTT_10340 PTT_19842
BZECOCCADRAFT_110329 COCCADRAFT_111505 COCCADRAFT_32392 COCCADRAFT_88943 COCCADRAFT_97222
BSCCOCSADRAFT_115498 COCSADRAFT_169033 COCSADRAFT_180960 COCSADRAFT_203669 COCSADRAFT_93339
BORCOCMIDRAFT_23298 COCMIDRAFT_35149 COCMIDRAFT_6415 COCMIDRAFT_8539
AALTCC77DRAFT_1025846 CC77DRAFT_404506 CC77DRAFT_984487
ZTRMYCGRDRAFT_72479
PFJMYCFIDRAFT_135650 MYCFIDRAFT_32111
FFUCLAFUR5_05880
BCOMBAUCODRAFT_124812 BAUCODRAFT_126186
NPAUCRNP2_10125 UCRNP2_3806 UCRNP2_5277 UCRNP2_554 UCRNP2_7680 UCRNP2_8569
TMLGSTUM_00003434001 GSTUM_00005736001 GSTUM_00007918001
TASAA1Q1_03969 A1Q1_06764 A1Q1_07864 A1Q1_07967
PPLPOSPLDRAFT_101011 POSPLDRAFT_90902
TVSTRAVEDRAFT_123403 TRAVEDRAFT_47634 TRAVEDRAFT_47635 TRAVEDRAFT_47636 TRAVEDRAFT_58730
DSQDICSQDRAFT_113295 DICSQDRAFT_175071 DICSQDRAFT_65759
PCOPHACADRAFT_149799 PHACADRAFT_202149 PHACADRAFT_246963 PHACADRAFT_264124
SHSSTEHIDRAFT_103548 STEHIDRAFT_153772 STEHIDRAFT_166249 STEHIDRAFT_49341 STEHIDRAFT_53821 STEHIDRAFT_56448 STEHIDRAFT_68295 STEHIDRAFT_99702
HIRHETIRDRAFT_152543 HETIRDRAFT_320909 HETIRDRAFT_386175 HETIRDRAFT_443851 HETIRDRAFT_459911 HETIRDRAFT_475911
PSQPUNSTDRAFT_77498
ADLAURDEDRAFT_136648 AURDEDRAFT_183516 AURDEDRAFT_75981
FMEFOMMEDRAFT_22425 FOMMEDRAFT_92013
GTRGLOTRDRAFT_104589 GLOTRDRAFT_137955 GLOTRDRAFT_40546 GLOTRDRAFT_76869 GLOTRDRAFT_96139
LBCLACBIDRAFT_188035
CCICC1G_14808 CC1G_14809
ABPAGABI1DRAFT118718(AGABI1DRAFT_118718) AGABI1DRAFT129336(AGABI1DRAFT_129336)
ABVAGABI2DRAFT180260(AGABI2DRAFT_180260) AGABI2DRAFT185850(AGABI2DRAFT_185850)
PCUBJR316_0007820
MRRMoror_1977 Moror_3210 Moror_6832
MOREE1B28_007781
SCMSCHCO_02573393(SCHCODRAFT_02573393) SCHCO_02573396(SCHCODRAFT_02573396) SCHCO_02619840(SCHCODRAFT_02619840) SCHCO_02636849(SCHCODRAFT_02636849) SCHCO_02687836(SCHCODRAFT_02687836)
CPUTCONPUDRAFT_164379 CONPUDRAFT_164380 CONPUDRAFT_59955 CONPUDRAFT_83128 CONPUDRAFT_85427 CONPUDRAFT_89327
SLASERLADRAFT_351441 SERLADRAFT_357363 SERLADRAFT_362748 SERLADRAFT_362787 SERLADRAFT_418880 SERLADRAFT_480556
WSEWALSEDRAFT_32583
WICJ056_002594
UMAUMAG_04107 UMAG_04348
PFPPFL1_04307
MGLMGL_4150 MGL_4156 MGL_4162
PGRPGTG_03817
MLRMELLADRAFT_109827 MELLADRAFT_113368 MELLADRAFT_36236 MELLADRAFT_38407
ACANACA1_342850
SERASer39006_020420
SERQCWC46_20425
MSQBKP64_00745
HAKKO116_00395
HAMHALO0393
HSRHSBAA_48470
HMDCTT34_16660
HSXHNO51_14970
ADIB5T_03289
AXEP40_15405
MMWMmwyl1_3129
MPRIMP3633_1126
MFOIJSY38_15710
MPRFJ8N69_14100
MRHIKDW99_14420
MGEOCFI10_06160 CFI10_14990
MSECLN244_05115
MARLHH196_03985 HH196_04645
AJPAMJAP_1095
GSNYC6258_03595
RFOREIFOR_02480
BYIBYI23_B006180
BUEBRPE67_BCDS08460
BPHBphy_6383
BGEBC1002_6612
BCAIK788_0003229
PSPWBJG93_30535
PHSC2L64_25955
PTERC2L65_22430
PTROG5S35_32215
PACSFAZ98_33560
BUOBRPE64_CCDS03280
CDNBN940_06106 BN940_10251 BN940_12096
PIGEGT29_07580
COFFOZ74_08500
LIML103DPR2_02688(pcpB)
HYBQ5W_00715
HYLLPB072_07895
HPSEHPF_00160(mhpA1)
HTNKI616_00115
THUAC731_007950
AVPAVENP_2158
MESOBSQ44_01280
NIYFQ775_18375
ORMHTY61_12230
ARAArad_7218
NGLRG1141_CH43650
NGGRG540_CH44060
NEOCYG48_19515
RHTNT26_0615
ABAWD5400_03830
BJAblr4222(blr4222)
BJUBJ6T_55730
BJPRN69_27015
BRABRADO5224
BBTBBta_5688
BRSS23_40400
AOLS58_24710
BRCBCCGELA001_17695
BRADBF49_0830
BICLMTR13_15040
BROBRAD285_2007
BOTCIT37_32895
BRQCIT40_13830
BGQX265_17740
BGZXH91_19715
BSYMCIT39_12975
BBETF8237_00545
BARHWN72_23355
BVZBRAD3257_4791
BDGLPJ38_23155
TRBHB776_17945
BVVBHK69_13245
BOIBLM15_28125
METM446_6872
MNOMnod_0822 Mnod_3235 Mnod_8211
MMESMMSR116_21730
MTEADK419_05635
RHZRHPLAN_06530
PHLKKY_2081
LAPACP90_25325
LABTFIU93_03150(pcpB)
LAGGB0E33_08760
PSTGE8M01_27575
RPONG3256_06045
PHPPhaeoP97_03895
YPACCEW88_03045
YANAYJ57_10090
SUAMBOO69_14500
SULZC1J03_22775
SULIC1J05_11125
SMEDJNX03_10755
SPSESULPSESMR1_02017(mobA)
RIDRIdsm_02797(pcpB)
SAGUCDO87_00660
OCDFHY55_16615
TGLHFZ77_16325
PDEPden_3488
DAAAKL17_0088
THWBMG03_05990
TECAKL02_004815
SALOEF888_06870
HMLHmaOT1_14265
POZI0K15_18185
PGVSL003B_1806
THASC6Y53_03870
GCEKYE46_09725
RGIRGI145_21255
ROSCTJ15_00760
RMUCFOB66_01935
MAGXXM1_0851
MAGNWV31_12590
NACINUH88_05730
APBSAR116_2504
CGLCgl0050(Cgl0050) Cgl2681(Cgl2681)
CGBcg0070 cg2966
CGUWA5_0050 WA5_2588
CGTcgR_2584
CGSC624_13170
CGGC629_13175
CGMcgp_2966
CGJAR0_13005
CGQCGLAR1_12870
CGXSB89_12645
CARcauri_2503
CHNA605_03340
CMDB841_00165
CAZCARG_02975
CCGCCASEI_13880
CDOCDOO_05295
CEICEPID_11910
CTEDCTEST_00855
CDXCDES_12135
CSPWM42_1475
CSTACSTAT_12895
CCJZccrud_12070
CPHOCPHO_12190
CFCCFLV_12715
CSTRCBE89_01295
CAQUCAQU_01280
CAMGCAMM_01760 CAMM_12580
CMINNCTC10288_00046(pcpB_1)
CPEGCPELA_07985(pcpB)
CGKCGERO_03130(pcpB)
CPSOCPPEL_08220(mhpA)
CSURN24_2763
CYZC3B44_06120
CPRPI6I69_06090
CGLUI6J20_09480
CCOECETAM_13220(pcpB2)
COKCOCCU_13950(pcpB2)
CCYCSCMU_34750 SCMU_39810
CUWLH390_08640
CPOYGP475_03025
BFVC628_00390 C628_13280
NFANFA_27810
NFRERS450000_01314(pcpB_3)
NBRO3I_022360
RHSA3Q41_02968(mobA)
GPOGPOL_c33240(mphP2)
LEIFHF024_04555
LSEF1C12_20435
MTSMTES_0649
MIMAKG07_00145
MIOAOA12_16485
MIXAB663_001719
MIPAXH82_11175
MCWA8L33_07045
MPALBO218_07705
MIHBJP65_05065
MICRBMW26_04705
MAURBOH66_13300
MHOSCXR34_14335
MFOLDXT68_04825
MOOBWL13_01222(mobA_2) BWL13_02299(mobA_3)
MLVCVS47_00667(mobA_1)
MWAE4K62_04510
MPRTET475_02095 ET475_04430
MOYCVS54_01111(mobA)
MCAWF6J84_11770 F6J84_14345
MLZF6J85_04285
MCHNHCR76_02425
MRNK8F61_08640
MICSC1N74_03250
MLIQNMQ05_05685
MVDAWU67_07895 AWU67_12480
AGYATC03_19490
AGMDCE93_14220
AARCG127AT_07120
AMAUDSM26151_30000(mobA_2)
ASOIMTP13_04810
CPHYB5808_01150
MSPOKXZ72_04285
SALDFVA74_00650
HUMDVJ78_01545
PLAPEAO79_05265
LEULeucomu_09955
LTREVS81_13865
LVIG7068_04605
LLUTK1X41_14595
AGGC1N71_13175
PSEVUSB125703_00554(mobA)
GSDM3M28_11635 M3M28_12225
ARTArth_3519
ARRARUE_c21850
ARMART_3167
ARLAFL94_05640 AFL94_15085
AREAL755_14175
AAQAOC05_17455
ARWMB46_07100 MB46_18300
ARHAHiyo8_37330
ARYATC04_02860 ATC04_12245
ARZAUT26_10090
ARUASPU41_04205
ARQBWQ92_08640
ARNCGK93_11880
ARXARZXY2_1943
ACRYAC20117_09310
ARTHC3B78_18110
ARTPE5206_16030
AAGINCTC2676_1_02846(pcpB_3)
AJGKKR91_16445
ASUNKG104_08340
ASUFMNQ99_02535 MNQ99_17020 MNQ99_17465
ARTYAHiyo4_47770
ARIUM93_13095
AAUAAur_2032 AAur_pTC20088
PUEFV140_10340
PNVJMY29_09560
ACHAchl_3607
APNAsphe3_36590
PSULAU252_11900
PSNINIBR502771_07025
PSEYGU243_14685
AAIAARI_11920 AARI_30840(1.14.13.-)
GARAOZ07_06265 AOZ07_15420
GCRGcLGCM259_0971
GLUF0M17_05910 F0M17_13870 F0M17_14710 F0M17_15605
GPRJQN66_06100 JQN66_15145
GMINMP99_15175
GMYXH9_02770 XH9_10580 XH9_11585
RSARSal33209_1826 RSal33209_1827
KRHKRH_22060
KPLKPaMU14_08330
KFVAS188_00885
KIIKocCE7_02545 KocCE7_11985
KODHBK84_02765 HBK84_11870
KVRCIB50_0000835(mobA_1)
MLUMlut_20120
MICKB1A86_00009985
MYUM8233_09665
RAMAIDM48_07790
RKRI6G21_04640
SATKSA2016_3430 SA2016_3900
NAEBHE16_07050
AULDCC27_010275
CIGE7744_13750
PAEYKUF55_01215 KUF55_17420
BRVCFK39_06205
BRZCFK38_04880
BSAUDWV08_11480
XYLET495_05320
IVAIsova_1931
CFICelf_2070
CELHGXP71_06025
CFENKG102_08670
SERJSGUI_0719
ORZFNH13_15095
BLYA2T55_04335
BLINBLSMQ_0802 BLSMQ_3182
BLUTEW640_09460
BCAUI6G59_07110
DCOSAMEA4475696_1574(pcpB)
MIKFOE78_15060
BSDBLASA_3125
MMARMODMU_2957 MODMU_2979
AMYCCU254_14910
PSEHXF36_28815
PHHAFB00_24075 AFB00_30345
PAUTPdca_26010
SACEGIY23_12045
TBWNCTC13354_01150(pcpB)
TPECHLG82_09275
ASLANCTC11923_02459(pcpB)
AREPID810_06155
FSLEJO69_09720
WIKH8R18_06670
RXYRxyl_0473
RRDRradSPS_2796
 » show all
Reference
1  [PMID:14478080]
  Authors
NAKAGAWA H, TAKEDA Y.
  Title
Phenol hydroxylase.
  Journal
Biochim Biophys Acta 62:423-6 (1962)
DOI:10.1016/0006-3002(62)90275-5
Reference
2  [PMID:4146224]
  Authors
Neujahr HY, Gaal A
  Title
Phenol hydroxylase from yeast. Purification and properties of the enzyme from Trichosporon cutaneum.
  Journal
Eur J Biochem 35:386-400 (1973)
DOI:10.1111/j.1432-1033.1973.tb02851.x
  Sequence
Reference
3  [PMID:810352]
  Authors
Neujahr HY, Gaal A.
  Title
Phenol hydroxylase from yeast. Sulfhydryl groups in phenol hydroxylase from Trichosporon cutaneum.
  Journal
Eur J Biochem 58:351-7 (1975)
DOI:10.1111/j.1432-1033.1975.tb02381.x
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.7
IUBMB Enzyme Nomenclature: 1.14.13.7
ExPASy - ENZYME nomenclature database: 1.14.13.7
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.7
BRENDA, the Enzyme Database: 1.14.13.7
CAS: 37256-84-1

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