Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
dammarenediol-II,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12beta-hydroxylating)
dammarenediol-II + [reduced NADPH---hemoprotein reductase] + O2 = protopanaxadiol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
[reduced NADPH---hemoprotein reductase] [CPD:
[oxidized NADPH---hemoprotein reductase] [CPD:
A cytochrome P-450 (heme-thiolate) protein isolated from ginseng (Panax ginseng). Involved in the biosynthetic pathway of ginsenosides.
EC 188.8.131.52 created 2013 as EC 184.108.40.206, transferred 2018 to EC 220.127.116.11
ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
K20545 dammarenediol 12-hydroxylase
Han JY, Kim HJ, Kwon YS, Choi YE
The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng.