cytochrome P450 3A10;
lithocholic acid 6beta-hydroxylase
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
lithocholate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6beta-hydroxylating)
lithocholate + [reduced NADPH---hemoprotein reductase] + O2 = 6beta-hydroxylithocholate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
[reduced NADPH---hemoprotein reductase] [CPD:
[oxidized NADPH---hemoprotein reductase] [CPD:
A cytochrome P-450 (heme-thiolate) protein from Mesocricetus auratus (golden hamster). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters .
EC 126.96.36.199 created 2005 as EC 188.8.131.52, transferred 2018 to EC 184.108.40.206
Teixeira J, Gil G
Cloning, expression, and regulation of lithocholic acid 6 beta-hydroxylase.
J Biol Chem 266:21030-6 (1991)
Chang TK, Teixeira J, Gil G, Waxman DJ.
The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation.
Subramanian A, Wang J, Gil G.
STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase.
The enzymes, regulation, and genetics of bile acid synthesis.