Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
A cytochrome P-450 (heme-thiolate) protein. The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 184.108.40.206, quinine 3-monooxygenase, EC 220.127.116.11, taurochenodeoxycholate 6-hydroxylase and EC 18.104.22.168, albendazole monooxygenase (sulfoxide-forming).
EC 22.214.171.124 created 2012 as EC 126.96.36.199, transferred 2017 to EC 188.8.131.52, modified 2018